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Generic name: Cilostazol
Drug class: Miscellaneous cardiovascular agents, Platelet aggregation inhibitors

Oral route(Tablet)

Pletal (cilostazole)

Cilostazol is not recommended for patients suffering from heart failure with congestive degree. Cilostazol and a number of its metabolites interfere with the enzyme phosphodiesterase III. Many drugs that have this pharmacologic effect have caused a reduction in survival when compared to placebo patients suffering from class III to IV heart failure .

It is believed that the Pletal trademark has now been removed from the U.S. If the generic version of this product were approved by FDA There may be alternatives that are generic.

Brand Name in US

  • Pletal

Available Dosage Forms:               

  • Tablet

Therapeutic Class: Platelet Aggregation Inhibitor

Pharmacologic Class: Phosphodiesterase Inhibitor

Uses for Pletal

Cilostazol increases the circulation of blood within the blood vessels. It can be used to ease leg pain due to inadequate circulation (intermittent claudication). Cilostazol allows you to move further without having to take a break due to leg pain.

This medication works by preventing blood from clotting, and also by relaxing or dilation of blood vessels.

This medicine can only be purchased on prescription from your physician.

Prior to making use of Pletal

When deciding whether to take an medication, the potential risks of using the medication must be evaluated against the benefits it can do. It is a choice both you and your doctor take. In this case it is important to take the following into assessed:


Inform your doctor whether you’ve had an unusual reaction or allergic reaction to this medicine , or any other medication. Inform your health care specialist if you suffer from any other kinds of allergies, like to dyes, food or preservatives or animals. For non-prescription medications, review the label or the the ingredients on the package carefully.


Studies that are appropriate have not been conducted to determine the connection of age and the effects of cilostazol on the child population. The safety and effectiveness of cilostazol have not been proven.


Studies that are appropriate so far have not revealed the existence of geriatric-specific issues that hinder the effectiveness of cilostazol for the elderly.


There aren’t enough studies of women that can determine the risk to infants when taking this medication while breastfeeding. Consider the benefits and the risks that could be associated with taking this medication when nursing.

Interactions with medications

While certain medications should not be combined in any way however, there are instances where two different medications can be combined even though interactions could occur. In these situations your doctor might want to alter the dosage, or take other precautions if needed. If you are taking this medication it is crucial to let your doctor know that you are using any one of these drugs that are listed below. These interactions have been determined based on their potential importance and may not be all-inclusive.

The use of this medication together with any of the following medications is not recommended. Your doctor could choose not to treat you with this medicine or modify any other medication you are taking.

  • Defibrotide

Utilizing this medicine in conjunction together with any of the following medicines is typically not advised, however it may be necessary in certain situations. If both medications are prescribed at the same time the doctor could alter the dosage or frequency you take either of the drugs.

  • Abametapir
  • Abciximab
  • Abiraterone Acetate
  • Aceclofenac
  • Acemetacin
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amiodarone
  • Amtolmetin Guacil
  • Anagrelide
  • Apixaban
  • Aprepitant
  • Argatroban
  • Aspirin
  • Atazanavir
  • Betrixaban
  • Bivalirudin
  • Boceprevir
  • Bromfenac
  • Bufexamac
  • Caplacizumab-yhdp
  • Celecoxib
  • Ceritinib
  • Choline Salicylate
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clonixin
  • Clopidogrel
  • Cobicistat
  • Conivaptan
  • Crizotinib
  • Dabigatran Etexilate
  • Danaparoid
  • Delavirdine
  • Desirudin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Diltiazem
  • Dipyridamole
  • Dipyrone
  • Dronedarone
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Eliglustat
  • Eptifibatide
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Esomeprazole
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Etravirine
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Fexinidazole
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Fosaprepitant
  • Fosnetupitant
  • Ginkgo
  • Heparin
  • Ibrutinib
  • Ibuprofen
  • Idelalisib
  • Imatinib
  • Indinavir
  • Indomethacin
  • Inotersen
  • Itraconazole
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lansoprazole
  • Lepirudin
  • Letermovir
  • Letrozole
  • Levomilnacipran
  • Lopinavir
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Miconazole
  • Mifepristone
  • Milnacipran
  • Moclobemide
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nefazodone
  • Nelfinavir
  • Nepafenac
  • Netupitant
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Omeprazole
  • Oxaprozin
  • Oxcarbazepine
  • Oxyphenbutazone
  • Pantoprazole
  • Parecoxib
  • Paroxetine
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Piketoprofen
  • Piperaquine
  • Piracetam
  • Piroxicam
  • Posaconazole
  • Prasugrel
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Rabeprazole
  • Regorafenib
  • Ritonavir
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Saquinavir
  • Selumetinib
  • Sertraline
  • Sodium Salicylate
  • Sulfinpyrazone
  • Sulindac
  • Telaprevir
  • Telithromycin
  • Tenoxicam
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tipranavir
  • Tirofiban
  • Tolfenamic Acid
  • Tolmetin
  • Trazodone
  • Valdecoxib
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Warfarin

Utilizing this medicine in conjunction together with the following medications could result in an increased risk of some adverse effects, however using both medicines could be the most beneficial option for you. If you are prescribed both medications by your doctor, they could alter the dosage or frequency at which you take either or both drugs.

  • Simvastatin

Interactions with alcohol, tobacco, or food

Certain medications are not recommended to be taken at or near the time of taking food, or eating specific kinds of food as interactions could happen. The use of tobacco or alcohol together with certain medications can result in interactions. The below interactions were selected because of their potential importance and are not intended to be comprehensive.

The use of this medicine in conjunction in conjunction with any of the following is generally not recommended, but it could be necessary in some instances. If taken together with other medications, your doctor could alter the dosage or frequency you take this medicine or provide you with specific instructions on the consumption of alcohol, food or tobacco.

  • Bitter Orange

Use of this medicine when you are using any of these could result in an increased risk of some side effects , but they are not unavoidable in certain situations. If used in conjunction the doctor may alter the dosage or frequency you take this medication, or give you specific directions regarding the use of fooditems, tobacco, alcohol or.

  • Grapefruit Juice

Other medical issues

The presence of any other medical issues could impact the effectiveness of this medication. Be sure to inform your physician if you suffer from any other medical issues including:

  • Active bleeding (including Peptic ulcers, bleeding within the skull) or
  • Troubles with blood clotting, or
  • Congestive heart failure should not be treated in patients with these ailments.
  • Heart rhythm disorders (eg tachycardia, etc.) or
  • The heart condition is known as ischemia, a history of or
  • Kidney disease or
  • Leukopenia (low levels of white blood cells) or
  • Liver disease or
  • Thrombocytopenia (low amount of platelets)–Use with care. This can cause the condition to worsen.

Proper use of Pletal

This medicine should be taken only as prescribed by your physician. Do not take more than it, don’t use it more often and don’t use it for longer duration than what your doctor has ordered.

The medicine must be accompanied by the patient’s information leaflet. Follow these directions attentively. Talk to your pharmacist or doctor for any additional concerns.

It is advised to take this medication every day.

Do not eat grapefruits or drink grapefruit juice when you are taking this medication.


The dosage of this medicine is different depending on the patient. Follow the doctor’s instructions or the instructions in the prescription. The information below is only the most common doses of this medication. If your dose differs you should not alter it until your doctor advises you to change it.

The amount of medicine you consume is contingent on how strong the drug. Additionally, the amount of doses you will take every day, the interval between doses and the amount of time you use the medication are contingent on the medical issue that you’re treating with the medication.

  • For oral dosage form (tablets):
    • To treat peripheral cardiovascular disease (circulation issues):
      • Adults – 100 milligrams (mg) twice per day, taking minimum 30 minutes before or 2 hours following dinner and breakfast. Your physician can alter your dosage as necessary.
      • Children–Use and dosage should be determined by a medical professional.

Missed dose

If you are missing an dose of this medicine make sure you take it as quickly as you can. If it’s nearing the time to take the next dose, you can skip the missed dose and then go back to your normal dosage schedule. Don’t double doses.


Place the medication in a sealed bottle at room temperatures, and away from moisture, heat and sunlight. Avoid the medicine from freezing.

Keep away from the reach of children.

Avoid keeping outdated medicines or medicines that are no longer required.

Discuss with your doctor what you can do with any medicine that you do not take.


Safety precautions when using Pletal

It is vital that your doctor examine your progress regularly to ensure this medication is working as it should. It is possible to have blood tests to look for any adverse side effects.

It can take a few weeks before this medication begins to take effect. If you think this medication is not effective, don’t stop using it on your own. Instead, talk to your physician.

Cilostazol may temporarily decrease the amount of cells called white that are present in your blood, increasing your risk of contracting an infection. It also reduces the amount of platelets that are essential for blood clotting. If this happens it is important to take certain precautions you can follow, especially in the event of a low blood-clotting to lower the risk of bleeding or infection.

  • If you can, stay clear of people who are suffering from illnesses. Consult your physician immediately in the event that you suspect you’re experiencing an infection or you develop a fever, hoarseness, chills, or cough and low back pain or side discomfort or pain or difficulty urinating.
  • Consult your physician immediately If you notice an unusual bleeding, bruising or swelling. You may also notice black or tarry stool or bloody stool or urine or the appearance of red spots on your skin.
  • Be cautious when using your regular brush, floss or toothpick. Your dentist, medical professional or nurse might suggest alternative methods to cleanse your gums and teeth. Talk to your doctor prior to having any dental procedure performed.
  • Don’t apply pressure to any of the eyes, or even your insides until just cleaned your hands and not touched anything else during the time.
  • Be cautious not to injure yourself when making use of sharp objects, like an safety razor or fingernail or nail cutters.
  • Avoid contact sports or any other instances where injuries or bruising may occur.

Get in touch with your doctor immediately If you notice any changes in your heartbeat. You may experience a rapid and pounding heartbeat, pulse, fainting or palpitations due to this medication.

Lightheadedness, dizziness, or fainting could occur when you are able to get up abruptly from a lying or sitting or seated position. Slowly getting up can aid. If the issue persists or worsens, check with your physician.

Cilostazol may cause heart problems. Talk to your doctor immediately if you experience chest tightness or pain and decreased urine output. dilation of neck veins, severe fatigue, irregular heartbeats or swelling of the fingers, face feet, lower legs, breathing problems or weight increase.

Tobacco products that contain tobacco like cigarettes can aggravate your health. The nicotine in cigarettes can cause blood vessels to narrow and can also impact how this medication works. So, it is recommended to not smoke.

Do not take any other medications in the absence of discussing with your physician. This includes prescription and prescription (over-the-counter OTC) medicine, herbal and vitamin supplements.

Pletal side effects

Alongside its necessary effects, some medicines may result in unwanted negative effects. While not all of these adverse effects can be present, if they do occur, they might require medical attention.

Talk to your doctor immediately in the event that any of these adverse effects happen:

More commonly

  • Heartbeats that are irregular or fast
  • The fever

Less well-known

  • Abnormal bleeding
  • Black or bloody tarry stool
  • Red spots or bruises appear on the skin
  • fainting
  • nausea or heartburn, nausea, or stomach indigestion (severe or ongoing)
  • nosebleeds
  • stiff neck
  • stomach cramps, pains burning (severe)
  • The tongue is swelling
  • Bloody vomit or material that resembles coffee grounds

Incidence unknown

  • Bleeding gums
  • bleeding tendency
  • Peeling, blistering, and loss of skin
  • blood in urine or in the stools
  • blurred vision
  • chest pain
  • chills
  • stool with a clay-colored color
  • confusion
  • cough or hoarseness or cough
  • The coughing up of blood
  • Dark urine that is dark
  • diarrhea
  • difficulties breathing
  • Drowsiness
  • A fever without or with chills
  • general feeling of fatigue or weakness
  • headaches, severe and sudden
  • inability to speak
  • eye itching
  • itching on the skin
  • Muscle or joint or muscle
  • Light-colored stools
  • Appetit loss
  • loss of consciousness
  • Lower back or side discomfort
  • nausea and vomiting
  • uncomfortable or painful urination
  • Red spots that are specific on the skin
  • Lesions of the skin that are red, typically with a purple-colored center
  • Red, irritated eyes
  • seizures
  • Skin itchy rash
  • Slurred speech
  • ulcers, sores and white marks on your lips, or within the mouth
  • stomach pain
  • swollen glands
  • temporary blindness
  • Unpleasant breath smell
  • unusual bleeding or bleeding that isn’t normal or
  • unusual fatigue or weakness
  • weakness in the leg or arm to one or the other side. suddenly and intense
  • infirmity of a an area of the body
  • Yellow eyes or skin

Seek emergency assistance immediately in the event that any of the following signs of an overdose are present:

The signs of an overdose

  • Lightheadedness or dizziness after getting up from a standing or sitting position.

There are some side effects that can occur which usually don’t require medical treatment. These side effects can be eliminated when the body adapts the medication. Additionally your doctor might be able to inform you how to avoid or minimize the effects of these adverse effects. Talk to your physician for any of these adverse effects persist or are uncomfortable or if there are any concerns regarding these:

More commonly

  • Back discomfort
  • dizziness
  • gas
  • headache
  • Increased cough
  • stiffness or pain in the muscles
  • pounding heartbeat
  • Runny or stuffy nose
  • sore throat
  • swelling of the legs or arms

Less popular

  • Bone pain
  • The throat is burning with a burning sensation or chest
  • difficulty swallowing
  • Hives
  • stiffness or pain in joints
  • Ringing or buzzing in the ears
  • swelling of the fingers, face, or lower legs

Incidence unknown

  • Bruising
  • the feeling of warmth
  • Pain
  • facial redness neck, arms, and, occasionally, the upper chest.

Other adverse side effects that are that are not listed can also occur in certain patients. If you experience any other symptoms, consult with your doctor.

More details

Always consult your physician to make sure the information presented on this page is applicable to your particular situation.


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