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Clopidogrel (Plavix)

Generic name: clopidogrel (kloe-PID-oh-grel) (Oral route)
Drug class: Platelet aggregation inhibitors

Oral route(Tablet)

plavixThe efficacy of clopidogrel sulfur is due to its antiplatelet effect that is dependent on the conversion of it into an active metabolite via the Cytochrome P450 (CYP) system, primarily CYP2C19. Clopidogrel hydrogen sulfate, when taken at the appropriate doses produces less active metabolite, and therefore has an effect that is less on platelet function for patients homozygous for alleles that are not functional of the CYP2C19 gene (termed “CYP2C19 poor metabolizers”). Tests can be performed to identify those that are CYP2C19 poor metabolism. You may consider using a different inhibitor of platelets P2Y12 in patients who are identified as CYP2C19 poor metabolism ..

Brands that are commonly used name(s)

In the U.S.

Available Dosage Forms:

  • Tablet

Therapeutic Class: Platelet Aggregation Inhibitor

Pharmacologic Class: ADP-Induced Aggregation Inhibitor

Uses for Plavix

Clopidogrel is taken on its own or in combination with aspirin to reduce the risk of having a heart attack or stroke. It is administered to patients suffering from an acute coronary syndrome (ACS) as well as to patients who have had heart attacks or chest pain that is severe, or a stroke, to those with other problems with circulation (eg peripheral arterial diseases) that may cause an attack or stroke. The acute coronary syndrome in which the flow of blood into the coronary artery is restricted.

A stroke or heart attack could be caused by a blood vessel that is blocked by the formation of a blood clot. Clopidogrel is an inhibitor of platelets. It lowers the risk that a blood clot could form because it stops platelets from joining together within the blood. Clopidogrel can also increase the risk of serious bleeding for some individuals.

This medicine can only be purchased on prescription from your physician.

Prior to using Plavix,

When deciding whether to take an medication, the potential risks of taking the medicine have to be considered against the benefits it can do. It is a choice you and your physician will take. To determine the appropriate medicine to be considered, the following factors should be assessed:


Discuss with your physician If you’ve ever experienced an unusual or unrelated reaction to this medication or any other medication. Inform your health care specialist if you suffer from any other kinds of allergies, like to dyes, food or preservatives or animals. For non-prescription medications, review the label or the ingredient list carefully.


The right studies haven’t been conducted to determine the connection of age and the effect of clopidogrel within the pediatric population. The safety and efficacy of clopidogrel haven’t been confirmed.


The studies that have been conducted so far have not revealed the existence of geriatric-specific issues that hinder the effectiveness of clopidogrel for the elderly.


There aren’t enough studies on women to determine the risk to infants when taking this medication while breastfeeding. Be sure to weigh the potential benefits against the risks that could be associated with using this medication during nursing.

Interactions with medications

Certain medicines shouldn’t be combined in any way In other instances, two different medications can be combined even though there is a chance of interaction. In these situations the doctor may decide to adjust the dose or take other precautions if required. If you are taking this medication it is crucial that you inform your healthcare provider that you are currently taking one or more of the medications mentioned below. The following interactions were chosen based on their potential importance and are not meant to be comprehensive.

The use of this medication together with any of the following medications is not recommended. Your doctor might choose not to treat you with this medicine or modify one of the other medications you are taking.

  • Defibrotide

Utilizing this medicine in conjunction together with any of the following medications is typically not advised, however it may be necessary in certain situations. If two medicines are prescribed in conjunction and your doctor recommends a change in the dosage or the frequency you take either of the drugs.


  • Aceclofenac
  • Acemetacin
  • Alfentanil
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amiodarone
  • Amlodipine
  • Amtolmetin Guacil
  • Anagrelide
  • Anileridine
  • Apalutamide
  • Apixaban
  • Ardeparin
  • Argatroban
  • Aspirin
  • Bemiparin
  • Benzhydrocodone
  • Betrixaban
  • Bivalirudin
  • Bromfenac
  • Bufexamac
  • Buprenorphine
  • Bupropion
  • Butorphanol
  • Caplacizumab-yhdp
  • Celecoxib
  • Certoparin
  • Choline Salicylate
  • Cilostazol
  • Cimetidine
  • Citalopram
  • Clevidipine
  • Clonixin
  • Cobicistat
  • Codeine
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Desirudin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Diacetylmorphine
  • Diclofenac
  • Difenoxin
  • Diflunisal
  • Dihydrocodeine
  • Diltiazem
  • Diphenoxylate
  • Dipyridamole
  • Dipyrone
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Enoxaparin
  • Eptifibatide
  • Escitalopram
  • Esomeprazole
  • Ethylmorphine
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Etravirine
  • Felbamate
  • Felbinac
  • Felodipine
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Heparin
  • Hydrocodone
  • Hydromorphone
  • Ibrutinib
  • Ibuprofen
  • Indomethacin
  • Inotersen
  • Isradipine
  • Ketobemidone
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lansoprazole
  • Lepirudin
  • Levomilnacipran
  • Levorphanol
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Meperidine
  • Methadone
  • Milnacipran
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Nabumetone
  • Nadroparin
  • Nalbuphine
  • Naproxen
  • Nefazodone
  • Nepafenac
  • Nicardipine
  • Nicomorphine
  • Nifedipine
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nimodipine
  • Nisoldipine
  • Omeprazole
  • Opium
  • Opium Alkaloids
  • Oxaprozin
  • Oxycodone
  • Oxymorphone
  • Oxyphenbutazone
  • Paclitaxel
  • Papaveretum
  • Parecoxib
  • Paregoric
  • Parnaparin
  • Paroxetine
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Piketoprofen
  • Piracetam
  • Piritramide
  • Piroxicam
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Rabeprazole
  • Remifentanil
  • Repaglinide
  • Reviparin
  • Rifampin
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Selexipag
  • Selumetinib
  • Sertraline
  • Sibutramine
  • Sodium Salicylate
  • Sufentanil
  • Sulindac
  • Tapentadol
  • Tenoxicam
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tilidine
  • Tinzaparin
  • Tolfenamic Acid
  • Tolmetin
  • Tramadol
  • Trazodone
  • Tucatinib
  • Valdecoxib
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vortioxetine
  • Warfarin

Utilizing this medicine in conjunction together with the following medications could result in an increased risk of some adverse effects, however having both medicines in combination could be the most effective treatment for you. If you are prescribed both medications by your doctor, they might alter the dosage or frequency of use either or both drugs.

  • Atorvastatin
  • Fosphenytoin
  • Ginkgo
  • Lovastatin
  • Phenytoin
  • Pioglitazone
  • Simvastatin
  • Vitamin A

Interactions with alcohol, tobacco, or food

Certain medications are not recommended to be taken at or near the time of having food items or eating particular kinds of food, as interactions can happen. Smoking or drinking alcohol in conjunction together with certain medications can create interactions. The below interactions were selected because of their potential importance and are not intended to be comprehensive.

The use of this medicine in conjunction in conjunction with any of the following is not recommended, however, it could be necessary in certain instances. If you take it with other medications with other medications, your doctor could alter the dosage or frequency you take this medication, or provide you with specific instructions on the consumption of alcohol, food, or tobacco.

  • Grapefruit Juice

Other medical conditions

The presence of any other medical conditions could affect the effectiveness of this medication. It is important to inform your physician if you suffer from any other medical issues particularly:

  • Active bleeding (eg Peptic ulcers, head injuries) or
  • Intracranial hemorrhage (bleeding within the head) The history of – Should not be utilized in patients with these disorders.
  • Recent or recent stroke
  • Transient Ischemic attack (TIA or mini-stroke) Recent – May cause the side effects to get more severe¹.

Proper use of Plavix

Use this medication exactly according to the instructions of your doctor. Clopidogrel is not effective when you take less of it than prescribed. If you take more clopidogrel than prescribed, it could increase the risk of having serious side effects, without having a greater impact on the positive effects.

The medicine includes a Medication Manual. It is crucial to read and comprehend the information. Make sure you ask your physician about anything you are unsure about.

It is possible to take this medication either with or without food.

If you’re also having the omeprazole (Prilosec(r)) (or esomeprazole) (Nexium(r)) take care to not use it at same time you are taking this medication. Consult your physician about using a different anti-inflammatory.

The doctor may advise patients to use aspirin when you’re taking Clopidogrel. Don’t alter the dosage or discontinue taking the aspirin without consulting your physician first.


The dosage of this medication is different to different people. Follow the doctor’s instructions or the instructions printed on your prescription. The information below is only the most common doses of this medication. If you have a dose that is different you should not alter it unless your doctor instructs you to change it.

The quantity of medicine you consume is contingent on how strong the medication. In addition, the number of doses that you are taking each day, the amount of time between doses, as well as the amount of time you use the medication are contingent on the medical issue that you’re treating using the medication.

  • For oral dosage form (tablets):
    • to prevent stroke or heart attack in patients suffering from an acute coronary syndrome (ACS):
      • Adults–Initially 300 milligrams (mg) given in a single dose. Then, a dose maintenance of 75 mg twice a daily. The doctor could also prescribe you aspirin in conjunction with this drug.
      • Children–Use and dosage should be provided by your physician.
    • To prevent stroke or heart attack for patients who have a history of cardiovascular disease, heart attacks or peripheral arterial diseases
      • Adults – 75 milligrams (mg) every day.
      • Children–Use and dosage must be recommended by your physician.

Missed dose

If you are missing the dose of this medication make sure you take it as quickly as you can. If it’s close to the time for your next dose, avoid the missed dose, and go back to your usual dose schedule. Don’t double dose.


Place the medication in a tightly sealed bottle at room temperatures, and away from moisture, heat, and bright light. Avoid getting frozen.

Keep away from the children’s reach.

Avoid keeping outdated medicines or medicines that are no longer required.

Consult your physician about to tell you how to dispose of any medication that you do not take.


Use of caution when taking Plavix

It is vital to have your doctor review your progress on a regular basis. This will enable your doctor to assess whether the medication is functioning effectively and determine whether or not you should use the medication. It is possible to conduct blood tests to determine if there are any adverse negative effects.

The doctor could perform an genetic test prior to prescribing this medication to determine whether you have a problem with a liver enzyme known as CYP2C19. This medication may not be effective in the case of this disorder.

Be sure to inform all medical professionals and dentists, nurses and pharmacists that you visit inform them that you’re taking this medication. Clopidogrel could increase the chance of serious bleeding in an operation, medical procedures (eg the coronary stent procedure) or certain types of dental procedures. It is possible to stop taking this medication for at least 5 days prior to an operation, medical procedure or dental procedure. Don’t discontinue taking your medication without the permission of your physician..

While taking this medication, if you suffer from bleeding, it could take longer than normal to stop, particularly when you’ve injured yourself. Avoid dangerous sports or other activities in which you may be cut, bruised or hurt. Be cautious when handling sharp objects like the razor and clippers for fingernails.

This medication can increase the risk of bleeding or bleeding or. Talk to your doctor immediately if you notice irregular bleeding or bleeding, dark stool, bloody stools, or tarry stools. in your urine or stool or the appearance of red spots on your face. Avoid picking your nose. If you must air your nostrils, make sure you do it slowly.

Do not alter your dosage or cease taking the medication without consulting your physician.

Talk to your doctor now if you experience changes in your mental state such as bloody or dark urine, trouble speaking or speaking, fever, paleness of your skin, red spots on your skin or body, seizures, weakness and yellow eyes or skin. These are signs of a rare , serious disease called thrombotic purpura (TTP).

This medication can cause allergic reactions, such as angioedema. These can be life-threatening and requires medical treatment. Talk to your doctor immediately if you notice a an excessive, hive-like swelling that is visible around your eyes, face and lips, tongue, the throat, hands, legs feet, sex organs, and feet.

Do not take any other medications in the absence of discussing with your physician. This includes prescription and prescription (over-the-counter OTC) medicine, herbal and vitamin supplements.

Plavix side effects

In addition to its beneficial effects, some medicines may produce unwanted side adverse effects. While not all of these negative side effects are likely to occur, if they occur, they might require medical attention.

Consult your physician immediately If any of these negative side effects occur:

More commonly

  • The collection of blood is beneath the skin
  • deep, dark purple bruise
  • itching and redness or swelling

Less well-known

  • Bloody nose
  • bloody black, bloody, or black stools with tarry or bloody stools
  • Bloody vomit or material that resembles coffee grounds


  • Bleeding in the eye
  • confusion
  • headache, abrupt, intense and persistent
  • nausea and vomiting

Incidence unknown

  • Anxiety
  • Peeling, blistering, and loss of skin
  • Bloating
  • blurred vision
  • Burning stomach pain in the upper part of the stomach
  • Changes in mental health
  • The chest may be tight or hurt.
  • cold sweats
  • Coma
  • constipation
  • cool, pale skin
  • hoarseness or cough
  • Bloody or dark urine
  • difficulties in swallowing or breathing
  • difficulties in speaking
  • faintness, dizziness, or lightheadedness after rising quickly from a sitting or lying or seated
  • fast heartbeat
  • the sensation of discomfort
  • A fever without or with chills
  • general feeling of fatigue or weakness
  • Itching, hives eruptions
  • more food cravings
  • indigestion
  • Joint inflammation
  • muscle or joint or muscle
  • A large, hive-like swelling appears on the eyelids, face and lips. It can also be seen on the tongue hands, throat feet, legs, sex organs
  • stool with a light color
  • Appetit loss
  • Side or lower back discomfort
  • The muscles are aching
  • Nervousness
  • nightmares
  • loud breathing
  • Urination that is painful or difficult to urinate
  • discomfort in the side that could radiate into the back
  • tiny red spots on the skin
  • Swelling or puffiness on the eyelids, around the eyes or lips or the tongue
  • The rash can be flat or tiny raised lesions on the skin
  • rectal bleeding
  • Red eyes that have irritated eyes
  • Red skin lesions, usually with a purple-colored center
  • Reddening of the skin particularly around the ears
  • seizures
  • Shaking
  • skin blisters
  • Speech slurred
  • sore throat
  • ulcers, sores, or white spots on the lips or inside the mouth
  • stomach cramps, tenderness or discomfort
  • sweating
  • eye swelling or face, or even the inside of the nose
  • inflammation or swelling of the mouth
  • swollen or painful glands
  • Trouble breathing
  • unusual bleeding or unusual bleeding or
  • Watery or bloody diarrhea
  • Yellow eyes or skin

Certain side effects can be experienced which usually don’t require medical treatment. These symptoms may disappear after treatment, as the body adapts your. Additionally your doctor could be able inform you ways to avoid or minimize the effects of these adverse effects. Talk to your doctor for any of these adverse effects persist or are uncomfortable or if there are any questions regarding these:

Incidence unknown

  • Taste change that is unusual taste or unpleasant (after) taste
  • difficult to move
  • losing sense of taste
  • Muscle cramps, aches, or stiffness
  • Redness or swelling joints
  • experiencing, hearing or sensing things that aren’t being experienced, heard or felt.

Other adverse side effects that are that are not listed can also occur in certain patients. If you experience any other side effects, you should consult with your doctor.

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