Integrilin (Eptifibatide)

Name of the generic: Eptifibatide (Intravenous route)


Brand name in the USA

Available Dosage Forms:

  • Solution

Therapeutic Class: Platelet Aggregation Inhibitor

Pharmacologic Class: Glycoprotein IIb/IIIa Inhibitor

Uses for Integrilin

Eptifibatide injections are used to stop blood clots from developing in the arteries of your heart following certain types chest pains or heart attack. It can also be administered for patients who have specific heart or blood vessel procedures, including coronary angioplasty.

This medication should be administered only under the supervision of a physician.

Before taking Integrilin

When you decide to take an medication, the potential risks of using the drug should be evaluated against the positive effects it could bring. This is a choice that you and your physician take. In this case to be considered, the following factors should be assessed:


Discuss with your physician If you’ve ever experienced an unusual reaction or allergic reaction to this medicine , or any other medication. Be sure to inform your health doctor if you are suffering from other allergies, like to dyes, foods preservatives, animals, or dyes. For non-prescription medications, look over the label or ingredient list carefully.


Studies have not been conducted to determine the connection of age to the effect of eptifibatide in the infant population. Safety and efficacy haven’t been proven.


Studies that are appropriate so far have not revealed specific geriatric issues that could restrict the use of eptifibatide injections for older patients. However, patients who are elderly are more likely to suffer from bleeding problems that may necessitate caution for patients who receive eptifibatide injections.


There aren’t enough studies of women that can determine the risks to babies when taking this medication while breastfeeding. Consider the benefits and the risks that could be associated with taking this medication when nursing.


Interactions with medications

Certain medicines shouldn’t be taken together In other instances, two different medications can be combined even though there is a chance of interaction. In these situations the doctor may decide to alter the dosage, or make other precautions required. If you are taking this medication, it is particularly important to let your doctor knows that there is a connection between any one of these drugs that are listed below. These interactions have been determined based on their potential importance and may not be all-inclusive.

The use of this medication together with any of the following medications is not advised. Your doctor could choose not to prescribe this medication or alter one of the other medications you are taking.

Combining this medication together with any of the following medications is generally not advised, however it may be necessary in some instances. If both medications are prescribed at the same time and your doctor recommends a change in the dosage or frequency you take one or both of the medications.


  • Aceclofenac
  • Acemetacin
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amtolmetin Guacil
  • Anagrelide
  • Apixaban
  • Ardeparin
  • Argatroban
  • Aspirin
  • Bemiparin
  • Betrixaban
  • Bivalirudin
  • Bromfenac
  • Bufexamac
  • Caplacizumab-yhdp
  • Celecoxib
  • Certoparin
  • Choline Salicylate
  • Cilostazol
  • Citalopram
  • Clonixin
  • Clopidogrel
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Desirudin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyridamole
  • Dipyrone
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Enoxaparin
  • Escitalopram
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Heparin
  • Ibrutinib
  • Ibuprofen
  • Indomethacin
  • Inotersen
  • Ketoprofen
  • Ketorolac
  • Lepirudin
  • Levomilnacipran
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Milnacipran
  • Morniflumate
  • Nabumetone
  • Nadroparin
  • Naproxen
  • Nefazodone
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Parnaparin
  • Paroxetine
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Piketoprofen
  • Piracetam
  • Piroxicam
  • Prasugrel
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Reviparin
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Selumetinib
  • Sertraline
  • Sodium Salicylate
  • Sulfinpyrazone
  • Sulindac
  • Tenoxicam
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tolfenamic Acid
  • Tolmetin
  • Trazodone
  • Treprostinil
  • Valdecoxib
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin

The combination of this medication together with the following medications could result in an increased risk of some adverse effects, however having both medicines in combination could be the most effective treatment for you. If you are prescribed both medications by your doctor, they could alter the dose or frequency at which you take one or both medications.

  • Vitamin A

Interactions with alcohol, tobacco, or food

Certain medications shouldn’t be used during or in conjunction with having food items or eating particular kinds of food, as interactions can happen. Smoking or drinking alcohol in conjunction together with certain medications can result in interactions. The below interactions were selected in light of their potential importance and may not be all-inclusive.

Other medical conditions

The presence of any other medical conditions could affect the effectiveness of this medication. It is important to inform your physician if you suffer from any other medical issues particularly:

  • Bleeding that is active (within the last thirty days) or
  • History of bleeding problems, or
  • Dialysis patients or
  • Hypertension (high blood pressure) extreme uncontrolled or
  • Major operation (within the last 6 weeks) or
  • Stroke (within 30 days of the onset bleeding from hemorrhagic stroke)–Should not be administered to patients suffering from these conditions.
  • Kidney disease – Use with cautiousness. The effect may be heightened due to the slow removal of the medication in the human body.

Proper use of Integrilin

A physician or other qualified health professional will prescribe the medicine. The medicine is administered via an injection in one of your veins.

You can also get other medications to stop the formation of blood clots that are harmful like the aspirin and heparin.

You get a continuous infusion of this medication over an interval of up to 4 days. In this period, you will be closely monitored to ensure the medication is working properly and not causing any unwanted negative side negative effects.

Use with caution when using Integrilin

It is vital to have your doctor examine you on a regular basis after you have left the hospital to check for any issues or unwelcome effects that could be caused by this medication. Make sure you keep all appointments.

It is possible to bruise and bleed more easily when taking this medication. Be extra cautious to avoid injury as long as the side effects from the medication have waned. For certain patients, this could take between 2 and 3 days. For others it could be longer. Discuss this with your doctor. this.

Talk to your doctor immediately if you notice abnormal bleeding, bruising, black or tarry stool; blood in your urine or stools, or red spots that are clearly visible on your face. Avoid picking your nose. If you must air your nostrils, do so gently. it slowly.

It is possible to be instructed to use a soft brush or to shave using the use of an electronic razor (not the razor) for some days after you’ve received the medication. This reduces the risk of bleeding.

Check for bleeding in open areas , such as the areas of needle punctures to aid in taking blood, administering shots, or inserting the catheter to perform a coronary catheterization, or an angioplasty. Also, look for the presence of blood within your urine, or the bowel movements. If you notice any injuries or bleeding, notify your doctor immediately.

Don’t take any other medication without discussing them with your physician. This includes prescription and non-prescription (over-the-counter OTC) medications as well as herbal or vitamin supplements.


Integrilin side effects

In addition to its beneficial effects, some medicines may result in unwanted adverse effects. Although not all negative side effects are likely to occur, if they occur, they could require medical attention.

Consult your physician or nurse right away when any of these adverse effects happen:

More popular

  • Stomach or abdominal pains or swelling
  • back pain , or backaches
  • Bladder bleeding
  • bleeding gums
  • Blood in the urine
  • Black or bloody stool with tarry or black blood.
  • blurred vision
  • confusion
  • constipation
  • It is coughing up blood.
  • difficulties swallowing or breathing
  • dizziness
  • faintness, dizziness or lightheadedness when rising quickly from a sitting or lying or seated
  • headache
  • headaches, severe and sudden
  • Vaginal bleeding
  • nausea and vomiting
  • nosebleeds
  • paralysis
  • The bleeding that occurs from cuts can last for a long time.
  • Black or red or black stools, tarry stool
  • Urine that is dark brown or red
  • severe stomach pain
  • breathlessness
  • sweating
  • unusual fatigue or weakness
  • the vomiting of blood or a substance which resembles coffee grounds
  • weak spots

Less popular

  • Find red spots that are visible on the skin


  • Cough
  • difficulty swallowing
  • fast heartbeat
  • Hives
  • Itching
  • The swelling or puffiness of the eyelids and around the eyes or lips or the tongue
  • the skin itchy rash
  • The chest is tight
  • wheezing

Incidence unknown

  • Trouble speaking
  • double vision
  • inability to move legs, arms or facial muscles
  • inability to speak
  • Slow speech

Other adverse side effects that are not listed could also be present in certain patients. If you experience any other side effects, you should consult with your physician.

For more information

Always consult your doctor to make sure the information presented on this page is applicable to your specific situation.


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