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Dipyridamole (Persantine)

The generic name is dipyridamole
Classification of drugs: Cardiac stressing agents, Platelet aggregation inhibitors

Brands name in USA

Dipyridamole (Persantine)
Dipyridamole (Persantine)
  • Persantine

Available Dosage Forms:

  • Tablet
  • Solution

Therapeutic Class: Platelet Aggregation Inhibitor

Pharmacologic Class: Phosphodiesterase Inhibitor

Uses for dipyridamole

Dipyridamole can be used to reduce the risk of suffering from strokes or other medical conditions which may arise in the event that a blood vessel becomes restricted due to blood clots. It is prescribed only in cases of a higher than usual possibility that problems could be present. It is, for instance, for those who had heart valves removed by mechanical valves because potentially blood clots that are dangerous are more likely to develop in those with these conditions. Dipyridamole helps to stop blood clots that could be dangerous from developing.

Dipyridamole can also be prescribed to treat other blood and heart ailments as recommended by your physician.

Dipyridamole is sometimes also utilized as medical tests that show the flow of blood towards your heart. For information on this use of dipyridamole, see Dipyridamole–Diagnostic (Systemic).

Dipyridamole is available only on the prescription of your physician.

Before using dipyridamole

When deciding whether to take any medicine, the dangers of using the medication must be evaluated against the good it can bring. This is a decision that you and your physician will take. In the case of dipyridamole, these are to be considered


Discuss with your physician whether you’ve had an unusual reaction or allergy to dipyridamole or other medications. Be sure to inform your health doctor if you are suffering from other kinds of allergies, for example, to dyes, food or preservatives or animals. For non-prescription medications, look over the label or the ingredients on the package carefully.


Dipyridamole has been evaluated only for adults and children over 12 years old. There isn’t any specific data on the comparison of dipyridamole use in children who are younger than 12 years of age to use in other age categories.


Dipyridamole is not studied particularly in older individuals who are taking the medication regularly to stop blood clots from creating. There isn’t any particular evidence comparing the use of dipyridamole by older people with other groups of age however, it is unlikely to cause any different side symptoms or issues for older individuals as those who are younger.


There aren’t enough research studies of women that can determine the risks to babies when using this medication while breastfeeding. Consider the benefits and the risk of using this medication while nursing.

Interactions with medications

While certain medications should not be taken together however, there are instances where two different medications can be combined even though there is a chance of interaction. In these instances your doctor might decide to alter the dosage, or take other precautions as required. If you’re taking dipyridamole it is crucial that you let your doctor know that they prescribe any one of these medications that are listed below. The following interactions were chosen based on their potential impact and are not all-inclusive.

The use of dipyridamole along together with any of these drugs is not recommended. Your physician may choose not to treat you with this drug or modify one of the other medications you are taking.

  • Defibrotide
  • Riociguat

The use of dipyridamole along together with any of these medications is generally not recommended, but it could be necessary in some instances. If two medicines are prescribed and your doctor recommends a change in the dosage or frequency you take one or both of the drugs.

  • Abciximab
  • Aceclofenac
  • Acemetacin
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amtolmetin Guacil
  • Anagrelide
  • Apixaban
  • Ardeparin
  • Argatroban
  • Bemiparin
  • Betrixaban
  • Bivalirudin
  • Bromfenac
  • Bufexamac
  • Caplacizumab-yhdp
  • Celecoxib
  • Certoparin
  • Choline Salicylate
  • Cilostazol
  • Citalopram
  • Clonixin
  • Clopidogrel
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Desirudin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Enoxaparin
  • Eptifibatide
  • Escitalopram
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Heparin
  • Ibrutinib
  • Ibuprofen
  • Indomethacin
  • Inotersen
  • Ketoprofen
  • Ketorolac
  • Lepirudin
  • Levomilnacipran
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Milnacipran
  • Morniflumate
  • Nabumetone
  • Nadroparin
  • Naproxen
  • Nefazodone
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Parnaparin
  • Paroxetine
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Piketoprofen
  • Piracetam
  • Piroxicam
  • Prasugrel
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Reviparin
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Selumetinib
  • Sertraline
  • Sodium Salicylate
  • Streptokinase
  • Sulfinpyrazone
  • Sulindac
  • Tenoxicam
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tolfenamic Acid
  • Tolmetin
  • Trazodone
  • Treprostinil
  • Valdecoxib
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin

Utilizing dipyridamole along together with the following drugs could cause an increased risk of some side effects. However, having both medicines in combination could be the most effective treatment for you. If both medications are prescribed in conjunction the doctor could alter the dosage or the frequency you take either or both medications.

  • Adenosine
  • Tenecteplase

Interactions with food, tobacco and alcohol

Certain medications shouldn’t be used during or in conjunction with taking food, or eating specific kinds of food as interactions could happen. The use of tobacco or alcohol along with certain medicines can result in interactions. The following interactions were chosen in light of their potential importance and are not intended to be comprehensive.

Other medical conditions

The presence of any other medical issues could impact the dosage of dipyridamole. It is important to inform your physician if you suffer from any other medical conditions particularly:

  • Chest pain – The chance of adverse reactions is higher
  • A high blood pressure and the large amount of dipyridamole may cause the condition to become worse

The proper use of dipyridamole

Dipyridamole is most effective in the presence of a steady amount of blood. To ensure that the amount is stable, dipyridamole needs to be taken in regular doses as directed by your physician.

Dipyridamole is best consumed with a glass (8 ounces) of water at least one hour prior to or two hours after eating. To lessen stomach discomfort, your physician may suggest taking the medication along in conjunction with milk or food.


The dosage of dipyridamole is likely to differ in different people. Follow the doctor’s instructions or the instructions in the prescription. This information is only the doses that are typical of dipyridamole. If you are taking a different dose you should not alter it unless your physician tells you to change it.

The quantity of medication you consume is contingent on how strong the drug. In addition, the number of doses you will take every day, the amount of time between doses and the amount of time you are taking the medicine will depend on the medical condition for which you’re taking the medication.

  • For the prevention of blood clots:
    • For oral dosage form (tablets):
      • Adults – The recommended dose is 75-100 milligrams (mg) four times per day, taken along with an anticoagulant (blood-thinning) medication.
      • Children–Use and dosage must be recommended by your physician.

Missed dose

If you have missed the dose of dipyridamole do it as quickly as you can. But, if it’s close to the time for the next dose, you can skip the dose you missed and go back to your normal dose schedule. Do not take double doses.


Keep the medication in a sealed bottle at room temperatures, and away from moisture, heat, and sunlight. Be sure to keep the medicine from the medicine from freezing.

Keep away from the reach of children.

Don’t keep old medicine or medicines that are no longer required.

Use caution when using dipyridamole.

Dipyridamole is often used in conjunction in conjunction with anticoagulants (blood thinner) or aspirin. The combination of these medicines could give better protection from bleeding blood clots, than any other medication taken on their own. However, the chance of bleeding could increase when dipyridamole used in conjunction along with aspirin. To decrease blood loss:

  • Do not take aspirin or any combination medication that contains aspirin unless the doctor who advised the use of dipyridamole recommends that you take aspirin. This is especially crucial when you’re taking an anticoagulant along with dipyridamole.
  • If you’ve been advised to take aspirin along with dipyridamole, only take the amount of aspirin recommended by your physician . If you require a medication to ease pain or fever, your physician may not recommend taking additional aspirin. It’s best to talk about this with your doctor to ensure you be aware of the medication to take.
  • Your doctor will be able to check your progress on a regular basis.

Inform all doctors and dentists you visit that you’re taking dipyridamole and whether or not you’re using the anticoagulant (blood thinner) or aspirin with it.

Lightheadedness, dizziness or fainting can occur, particularly when you are getting up from a sitting or lying position. Slowly getting up can aid. If the problem persists or worsens, consult with your physician.

Dipyridamole side effects

In addition to its beneficial effects, medicines can result in unwanted adverse effects. Although not all negative side effects are likely to occur, if they occur, they could require medical attention.

Consult your physician promptly should any of the following reactions occur:


  • Chest pain
  • gallstones
  • Neck tightness or swelling
  • Skin or eyes with yellow eyes

Certain side effects can be experienced which usually don’t require medical care. These symptoms may disappear when your body adjusts your. Additionally your doctor might be able to inform you ways to avoid or minimize certain adverse side effects. Talk to your doctor for any of these adverse effects persist or are uncomfortable or if there are any concerns about these:

More popular

  • Stomach or abdominal cramps
  • diarrhea
  • lightheadedness or dizziness

Less well-known


  • General discomfort, unusual fatigue or weakness
  • hair loss
  • joint swelling or pain
  • muscle pain
  • nose that is runny
  • Sneezing

Other adverse reactions that are not listed can also occur in certain patients. If you experience any other symptoms, consult with your physician.

More details

Always consult your doctor to confirm that the information provided on this page is applicable to your particular situation.



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