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Brilinta (ticagrelor)

Name of the generic: ticagrelor
Drug class: Platelet aggregation inhibitors

Oral route(Tablet)

brilintaTicagrelor may cause serious bleeding that can be fatal. Avoid use for patients who have active bleeding pathologically or with a the history bleeding from the intracranial area. Don’t begin for patients who require urgent CABG. If possible, stop bleeding while not stopping ticagrelor. Eliminating ticagrelor increases the chance of cardiovascular events that occur in the future. Aspirin doses that are maintained above 100 mg for patients with acute coronary syndrome decrease the efficacy of ticagrelor and should be abstained from .

Brands that are commonly used name(s)

In the U.S.

  • Brilinta

Available Dosage Forms:

  • Tablet

Therapeutic Class: Platelet Aggregation Inhibitor

Pharmacologic Class: ADP-Induced Aggregation Inhibitor

Uses for Brilinta

Ticagrelor is a medication that can be used on its own or with aspirin in order to decrease the risk of having a heart attack or stroke in patients suffering from an acute coronary syndrome (ACS) or having a history of heart attacks. Acute coronary syndrome is that causes blood flow into the heart gets hindered. It can also be used to lower the chance of blood clots developing in patients who have had stents placed in their bodies to treat ACS.

Ticagrelor may also be taken by itself or in combination with aspirin to decrease the chance of having a heart attack first or stroke for patients suffering from coronary arterial disease (CAD) that are susceptible of suffering stroke or heart attack. Coronary arterial disease is that causes circulation of blood to the heart has diminished.

Ticagrelor is also taken by itself or with aspirin in order to reduce the risk of suffering a stroke in patients suffering from acute ischemic stroke or high risk transient Ischemic Attack (TIA). A mini-stroke, also known as transient ischemic attack, is a condition that occurs when the flow of blood to brain cells is stopped and lasts for just several minutes.

A stroke or heart attack can be triggered due to a blood vessel that is located in the brain or in the heart is blocked by the formation of a blood clot. Ticagrelor decreases the likelihood that a dangerous blood clot is formed by preventing certain blood cells from colliding. The ticagrelor effect can also increase the risk of bleeding that is serious in certain individuals.

This medication is only available on prescription from your physician.

Before making use of Brilinta

When you decide to take an medication, the potential risks of taking the medicine have to be considered against the benefits it will bring. It is a choice you and your doctor take. In this case to be considered, the following factors should be assessed:


Inform your doctor whether you’ve had any allergic or unusual reaction to this medication or any other medications. Inform your health care doctor if you are suffering from other kinds of allergies, for example, to dyes, foods or preservatives or animals. For products that are not prescription-only, you must look over the label or ingredient list carefully.


Studies have not been conducted on the relation of age to the effect of ticagrelor in the children’s population. The safety and effectiveness of ticagrelor have not been established.


Studies that are appropriate so far have not revealed the existence of geriatric-specific issues that hinder the effectiveness of ticagrelor among the elderly.


There are no studies that are sufficient of women that can determine the risks to babies when using this medication while breastfeeding. Consider the benefits and the risks that could be associated with using this medication during nursing.

Interactions with medications

While certain medications should not be combined in any way however, there are instances where two medicines can be taken together, even if there is a chance of interaction. In these situations the doctor may decide to alter the dosage, or make other precautions needed. If you’re taking this medication it is crucial that you inform your healthcare provider whether you’re currently taking one or more of the medications mentioned below. These interactions have been chosen based on their potential importance and may not be all-inclusive.

Utilizing this medicine in conjunction together with any of the following medications is not advised. Your doctor could decide to not treat you with this medicine or modify any other medication you are taking.

  • Defibrotide
  • Itraconazole

Combining this medication together with any of the following medicines is typically not advised, but could be required in certain instances. If two medications are prescribed in conjunction and your doctor recommends a change in the dosage or frequency you take either of the medications.

  • Abametapir
  • Abciximab
  • Aceclofenac
  • Acemetacin
  • Alipogene Tiparvovec
  • Amiodarone
  • Amtolmetin Guacil
  • Anagrelide
  • Apalutamide
  • Apixaban
  • Argatroban
  • Aspirin
  • Atazanavir
  • Belzutifan
  • Betrixaban
  • Bivalirudin
  • Bromfenac
  • Bufexamac
  • Caplacizumab-yhdp
  • Carbamazepine
  • Celecoxib
  • Ceritinib
  • Choline Salicylate
  • Cilostazol
  • Citalopram
  • Clarithromycin
  • Clonixin
  • Clopidogrel
  • Cobicistat
  • Dabigatran Etexilate
  • Danaparoid
  • Desirudin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyridamole
  • Dipyrone
  • Domperidone
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Droxicam
  • Duvelisib
  • Edoxaban
  • Eliglustat
  • Enzalutamide
  • Eptifibatide
  • Escitalopram
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Fexinidazole
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Fosnetupitant
  • Fosphenytoin
  • Heparin
  • Ibrutinib
  • Ibuprofen
  • Idelalisib
  • Ifosfamide
  • Indinavir
  • Indomethacin
  • Inotersen
  • Ivosidenib
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Larotrectinib
  • Lefamulin
  • Lepirudin
  • Levomilnacipran
  • Lorlatinib
  • Lornoxicam
  • Loxoprofen
  • Lumacaftor
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Mitotane
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Nabumetone
  • Naloxegol
  • Naproxen
  • Nefazodone
  • Nelfinavir
  • Nepafenac
  • Netupitant
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Olaparib
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Paroxetine
  • Phenindione
  • Phenobarbital
  • Phenprocoumon
  • Phenylbutazone
  • Phenytoin
  • Piketoprofen
  • Piperaquine
  • Piracetam
  • Piroxicam
  • Pixantrone
  • Prasugrel
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Rifampin
  • Ritonavir
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Saquinavir
  • Selumetinib
  • Sertraline
  • Simeprevir
  • Sodium Salicylate
  • St John’s Wort
  • Sulfinpyrazone
  • Sulindac
  • Telithromycin
  • Tenoxicam
  • Tiaprofenic Acid
  • Vortioxetine
  • Warfarin

Utilizing this medicine in conjunction together with the following drugs could cause an increased chance of experiencing certain adverse reactions, but taking both medications could be the best option for you. If you are prescribed both medications in combination, your physician could alter the dosage or frequency at which you take either or both medications.

  • Digoxin
  • Simvastatin

Interactions with alcohol, tobacco, or food

Certain medications are not recommended to be taken at or in conjunction with having food items or eating particular kinds of food as interactions could happen. The use of tobacco or alcohol along with certain medicines can result in interactions. The following interactions have been chosen because of their potential impact and may not be all-inclusive.

Utilizing this medicine in conjunction together with the following is not advised, but it could be necessary in certain situations. If taken together with other medications, your doctor could alter the dosage or frequency you take this medicine or provide specific directions on the consumption of alcohol, food, or tobacco.

  • Grapefruit Juice

Other medical issues

The presence of medical conditions could affect the usage of this medication. Be sure to inform your physician if you suffer from any other medical issues including:

  • The presence of bleeding, pathological or active (eg due to head injuries or peptic ulcers) or
  • Intracacranial hemorrhage (bleeding inside the brain) The history of or
  • Liver disease that is severe should not be utilized in patients suffering from these conditions.
  • Bleeding issues, history of or
  • Heart rhythm issues or the history of
  • Ailment of the lungs or breathing (eg asthma, asthma or COPD)–Use with care. It could make the conditions worse.
  • Moderate Liver Disease. Use with cautiousness. The adverse effects could be enhanced due to the slower elimination of the medication out of the body.
  • Surgery, recent–use with cautiousness. The side effects could get more serious.

Proper use of Brilinta

You should take this medicine according to your doctor’s instructions. Ticagrelor is not working properly in the event that you take less it than prescribed. If you take more ticagrelor than prescribed, it can increase the likelihood of having serious side effects, without affecting the beneficial effects.

The medicine includes a Medication Guide. It is crucial to understand and read the contents of this guide. It is important to consult your physician about anything you are unsure about.

You should take this medicine in the same order every throughout the day. You can take it either with or without meals.

If you cannot swallow the tablet whole:

  • It is possible to crush the tablets and mix them in an ice-cold glass and consume it immediately.
  • Fill the glass with water, stir it, then take a second swallow.
  • The mixture can also be administered via an Nasogastric tube. Rinse the tube with water to wash all the medicine out of the stomach.

The doctor may advise the patient to use aspirin if you’re taking ticagrelor. Don’t alter the dosage or stop using the aspirin without speaking with your physician first.


The dosage of this medicine is different depending on the patient. Follow the instructions of your physician or the instructions printed on your prescription. The information below is only the doses that are typical of this medication. If you have a dose that is different you should not alter it until your doctor advises you to change it.

The quantity of medicine you are taking is determined by how strong the medication. In addition, the number of doses you will take every day, the amount of time between doses, as well as the duration of time that you are taking the medicine will depend on the medical condition that you’re treating with the medication.

  • For oral dosage form (tablets):
    • To prevent stroke or heart attack for patients with chronic coronary syndrome (ACS) or an ACS-related heart attack:
      • Adults: At first 180 milligrams (mg) given as one dose. Following that 90 mg twice daily for the first year following an ACS incident. After that, you should take 60 mg twice times per day after one year. Your doctor might also prescribe you an aspirin dose maintenance 75 to 100 mg every day, to take along with this medication. Don’t exceed 100 mg of aspirin a day.
      • Children–Use and dosage should be verified by your physician.
    • In order to prevent the onset of a cardiovascular attack, stroke or heart disease patients suffering from coronary arteriac (CAD): (CAD):
      • Adults – 60 milligrams (mg) twice a every day. Your doctor might also prescribe you a daily dose of aspirin 75-100 mg daily to take along with this drug. Do not exceed 100 mg aspirin each day.
      • Children–Use and dosage must be determined by your physician.
    • To prevent strokes for patients with an acute transient ischemic attack (TIA):
      • Adults: At first 180 milligrams (mg) given as one dose. Following that 90 mg 2 times daily over a period of 30 to 60 days. Your doctor could also prescribe you an initial dose of aspirin 300 to 325 mg as well as a maintenance dose of 75-100 mg twice every day. These should be taken along with this medication. Don’t exceed 100 mg of aspirin a day.
      • Children–Use and dosage should be determined by your physician.

Missed dose

If you do not take an dose of this medicine take it easy and return to your usual dosing schedule. Do not take double doses.


Keep the medication in a sealed bottle at room temperatures, and away from moisture, heat, and sunlight. Avoid the medicine from freezing.

Keep your items out of reach of children.

Don’t keep old medicine or medications that are no longer needed.

Discuss with your doctor to tell you how to dispose of any medication that you do not take.


Safety precautions when using Brilinta

It is vital to have your doctor review your progress every time you visit. This allows your doctor to assess whether the medication is working well and decide whether you should continue to take the medication. It is possible to conduct blood tests to determine if there are any adverse side effects.

Be sure to inform all medical professionals and dentists, nurses and pharmacists you visit you’re taking this medication. Ticagrelor could increase the chance of bleeding serious in surgical procedures, other medical procedures (eg coronary artery bypass surgery or CABG) as well as certain types of dental procedures. It is possible to stop using this drug for at least 5 days prior to an operation, medical procedure or dental procedure. The results of certain medical tests could affect the results of medical tests as well. medication.

Do not alter the dose and/or stop using this medication without first consulting with your physician. Doing so could increase your risk of suffering an attack on your heart or blood clotting issues, or other serious illnesses.

While taking this medicine, if suffer from bleeding, it might take longer than normal to stop, particularly in the event that you’ve hurt yourself. Avoid dangerous sports or other activities that could cause you to be cut, bruised or hurt. Be cautious when handling sharp objects such as the razor and clippers for fingernails.

This medicine can increase the chance of bleeding or bleeding or. Consult your physician right in case you notice abnormal bleeding, bruising or swelling. Also, you may notice black stool, tarry or blood in your stool or urine or the appearance of red spots on your face. Avoid picking your nose. If you have to air your nostrils, do so gently. it slowly.

Contact your physician immediately when you feel tightness in your chest or trouble breathing while awake or asleep. These could be indications of a more serious lung or breathing issue (eg Cheyne-Stokes respiration).

This medication could cause heart rhythm issues (eg bradyarrhythmia). Talk to your doctor now if you are experiencing chest discomfort or pain, or dizziness, lightheadedness, difficulty breathing, fainting and irregular heartbeats, or a slow or slow heartbeat, or unusual fatigue.

Don’t take other prescriptions in the absence of discussing with your physician. This includes prescription and non-prescription (over-the-counter OTC) medicine, herbal and vitamin supplements.

Brilinta side effects

In addition to its beneficial effects, medicines can produce unwanted side negative effects. While not all negative side effects are likely to occur, if they occur, they could require medical attention.

Consult your physician immediately If any of these adverse effects happen:

More commonly

  • Back back pain
  • bleeding gums
  • blurred vision
  • chest pain, tightness or pain
  • confusion
  • cough
  • The coughing up of blood
  • difficulty or trouble breathing
  • dizziness, faintness or lightheadedness after rising abruptly from a sitting or lying in a supine or lying
  • heartbeats that are slow, fast or irregular heartbeat
  • headache
  • Vaginal bleeding
  • dizziness, lightheadedness, or fainting
  • loss of consciousness
  • nausea or vomiting
  • Nervousness
  • nosebleeds
  • paralysis
  • The eardrums are pounding
  • The bleeding that occurs from cuts can last for a long time.
  • black or red stool, tarry stool
  • Urine that is dark brown or red
  • sweating
  • unusual bleeding or unusual bleeding or
  • unusual weakness or fatigue


  • Changes in mental state
  • problems with speaking
  • febrile
  • pale skin
  • Red spots that are specific on the skin
  • seizures
  • Skin or eyes with yellow eyes

Incidence unknown

  • Problems swallowing
  • Large, hive-like swellings around the eyes, face and lips. It can also be seen on the tongue throat, hands, feet, legs, or sexual organs
  • Rash

There are some side effects that can occur but they usually don’t require medical treatment. These side effects can disappear when your body adjusts the medication. Additionally your doctor could be able inform you how to avoid or lessen certain adverse side effects. Consult your doctor for any of these symptoms persist or become troubling or if you have questions regarding these:

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Other side effects that aren’t mentioned may occur in certain patients. If you observe any other side effects, you should consult with your physician.

Consult your physician to seek medical advice on possible side effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.



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