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Aggrenox (dipyridamole and aspirin)

Generical name:  Aspirin and dipyridamole and  
Drug class: Platelet aggregation inhibitors

Brand name in US

Aggrenox (dipyridamole and aspirin)
 Aggrenox (dipyridamole and aspirin)
  • Aggrenox

Available Dosage Forms:

  • Capsule, Extended Release

Therapeutic Class: Platelet Aggregation Inhibitor, Phosphodiesterase Inhibitor/Salicylate, Aspirin Combination

Pharmacologic Class: NSAID

Chemical Class: Salicylate, Aspirin

Uses for Aggrenox                 

The combination of dipyridamole and aspirin can be used to protect strokes from happening. Strokes happen when a vein in your brain gets blockage through blood clots. The medication will reduce blood flow and to prevent the formation of blood clots. It should only be used in cases of substantial chance that problems with blood clotting could be present.

This medication is only available upon prescription by your doctor.

Before making use of Aggrenox

In making a decision to use any medicine, the dangers of using the medication must be evaluated against the good it can bring. It is a choice you and your physician will take. To determine the appropriate medicine to be considered, the following factors should be taken into consideration:


Discuss with your physician whether you’ve had an unusual or unrelated reaction to this medicine , or any other medications. Inform your health care doctor if you are suffering from other allergies, like to dyes, food preservatives, animals, or dyes. For non-prescription medications, review the label or the the ingredients on the package carefully.


Studies haven’t been conducted on the relation of age to the effect of dipyridamole aspirin combination in the population of children. Due to the toxic nature of aspirin, the use of aspirin in adolescents and children is not advised.


Studies that are appropriate so far have not revealed specific geriatric issues that could hinder the effectiveness of the combination of dipyridamole and aspirin for the elderly.


There aren’t enough research studies of women that can determine the risks to babies when taking this medication while breastfeeding. Be sure to weigh the benefits of this medication against the risk of using this medication during nursing.

Interactions between medicines

Certain medicines shouldn’t be combined in any way In other instances, two different medications can be combined even though interactions could occur. In these instances your doctor might want to adjust the dosage or take other precautions if needed. When you’re taking this medication it is crucial to let your doctor know that you are currently taking one or more of the medications that are listed below. The following interactions were determined based on their potential impact and are not meant to be comprehensive.

The use of this medication together with any of the following medications is not advised. Your doctor could decide to not prescribe this medication or alter one of the other medications you are taking.

  • Defibrotide
  • Dichlorphenamide
  • Influenza Virus Vaccine, Live
  • Ketorolac
  • Riociguat

Combining this medication together with any of the following medications is generally not advised, however it may be necessary in certain situations. If two medicines are prescribed in conjunction and your doctor recommends a change in the dosage or frequency you take either of the drugs.

  • Abciximab
  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amiloride
  • Amineptine
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Amtolmetin Guacil
  • Anagrelide
  • Anisindione
  • Apixaban
  • Ardeparin
  • Argatroban
  • Bemiparin
  • Bendroflumethiazide
  • Benzthiazide
  • Betrixaban
  • Bivalirudin
  • Bromfenac
  • Bufexamac
  • Bumetanide
  • Caplacizumab-yhdp
  • Celecoxib
  • Certoparin
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Choline Salicylate
  • Cilostazol
  • Citalopram
  • Clomipramine
  • Clonixin
  • Clopamide
  • Clopidogrel
  • Cyclopenthiazide
  • Cyclosporine
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Desipramine
  • Desirudin
  • Desmopressin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Diazoxide
  • Dibenzepin
  • Diclofenac
  • Dicumarol
  • Diflunisal
  • Digoxin
  • Dipyrone
  • Dothiepin
  • Doxepin
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Enoxaparin
  • Eplerenone
  • Eptifibatide
  • Escitalopram
  • Ethacrynic Acid
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Feverfew
  • Floctafenine
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Furosemide
  • Ginkgo
  • Glimepiride
  • Glipizide
  • Glyburide
  • Gossypol
  • Heparin
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Ibrutinib
  • Ibuprofen
  • Imipramine
  • Indapamide
  • Indomethacin
  • Inotersen
  • Ketoprofen
  • Ketorolac
  • Lepirudin
  • Levomilnacipran
  • Lithium
  • Lofepramine
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Macimorelin
  • Meclofenamate
  • Mefenamic Acid
  • Melitracen
  • Meloxicam
  • Metformin
  • Methotrexate
  • Methyclothiazide
  • Metolazone
  • Milnacipran
  • Morniflumate
  • Nabumetone
  • Nadroparin
  • Naproxen
  • Nateglinide
  • Nefazodone
  • Nepafenac
  • Nicorandil
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nortriptyline
  • Opipramol
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Parnaparin
  • Paroxetine
  • Pemetrexed
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Piketoprofen
  • Piracetam
  • Piroxicam
  • Polythiazide
  • Pranoprofen
  • Prasugrel
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Protriptyline
  • Repaglinide
  • Reteplase, Recombinant
  • Reviparin
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Selumetinib
  • Sertraline
  • Sodium Salicylate
  • Spironolactone
  • Streptokinase
  • Sulfinpyrazone
  • Sulindac
  • Sulodexide
  • Tacrolimus
  • Tenofovir Disoproxil Fumarate
  • Tenoxicam
  • Tianeptine
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Torsemide
  • Trazodone
  • Treprostinil
  • Triamterene
  • Trichlormethiazide
  • Trimipramine
  • Valdecoxib
  • Varicella Virus Vaccine, Live
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin
  • Xipamide

Utilizing this medicine in conjunction in conjunction with one of the following medications could result in an increased risk of some side effects. However, having both medicines in combination could be the most beneficial option for you. If you are prescribed both medications by your doctor, they might alter the dosage or frequency at which you take either or both drugs.

  • Acebutolol
  • Adenosine
  • Atenolol
  • Betamethasone
  • Betaxolol
  • Bisoprolol
  • Captopril
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Cortisone
  • Delapril
  • Dexamethasone
  • Enalaprilat
  • Enalapril Maleate
  • Esmolol
  • Imidapril
  • Labetalol
  • Levobunolol
  • Lisinopril
  • Methylprednisolone
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Nitroglycerin
  • Oxprenolol
  • Paramethasone
  • Penbutolol
  • Pindolol
  • Practolol
  • Prednisolone
  • Prednisone
  • Probenecid
  • Propranolol
  • Sotalol
  • Streptokinase
  • Tamarind
  • Temocapril
  • Tenecteplase
  • Timolol
  • Triamcinolone
  • Valproic Acid

Interactions with alcohol, tobacco, or food

Certain medications shouldn’t be taken during or near the time of having food items or eating particular kinds of food, as interactions can happen. Smoking or drinking alcohol in conjunction along with certain medications may result in interactions. The below interactions were selected because of their potential impact and are not intended to be comprehensive.

In the event of using this medicine, any of these could increase the chance of experiencing certain adverse effects , but they are not unavoidable in certain situations. If you are taking this medicine with other medicines with other medications, your doctor could alter the dose or frequency you take this medicine or provide you with specific instructions regarding the consumption of food, alcohol or tobacco.

  • Ethanol

Other medical issues

The presence of medical issues could impact the usage of this medicine. It is important to inform your physician if you suffer from any other medical issues particularly:

  • Use of alcohol (3 or more drinks in a day) or
  • Troubles with bleeding or
  • Liver disease, serious or
  • Stomach ulcers, past history of cause side effects to get more severe.
  • Angina (severe chest pain) Unsteady or
  • Heart attack, recent or
  • Heart diseases (e.g. coronary arterial disease) or
  • The term hypotension refers to the condition of having low blood pressure (low blood pressure) or
  • Kidney disease, whether severe or
  • Myasthenia Gravis (severe muscular weakness)–Use with cautiousness. This can cause the condition to get worse.
  • Asthma, nasal polyps, and rhinoitis, history of or
  • Nonsteroidal anti-inflammatory medicine (NSAID) allergic (e.g. diclofenac ibuprofen naproxen, Advil(r), Aleve(r), Celebrex(r), Voltaren(r)) or
  • Reye’s Syndrome (metabolic disorder)–Should not be utilized for patients suffering from these conditions.

Proper use of Aggrenox

This medicine should be taken precisely as prescribed by your physician. Don’t take more than you need and don’t take it for longer than the prescription your doctor gave you. This medicine is effective when there is a steady amount in your blood. To ensure that blood levels remain constant you should take this medication daily at the same time every day. Don’t miss any doses.

The medicine includes an information leaflet for patients. Follow the directions carefully. Talk to your doctor if have any concerns.

Take the capsules in whole. Do not crush, break or chew them.

It is possible to take this medication in combination with or without food.

If you experience severe headache following the use of this medication, consult your doctor immediately. Your doctor may temporarily change your dose.


The dose of this medication can differ to different people. Follow your doctor’s prescriptions or the instructions printed on your prescription. The information below is only the doses that are typical of this medication. If you have a dose that is different don’t alter it until your doctor advises you to change it.

The quantity of medicine you are taking is determined by how strong the medication. In addition, the number of doses you will take every day, the interval between doses and the amount of time you are taking the medicine will are contingent on the medical issue that you’re treating with the medication.

  • For oral dosage form (capsules):
    • To prevent stroke:
      • Adults: One capsule twice a day, once in the morning and then later in the night.
      • Children are not advised to use the product.

Missed dose

If you do not take an dose of this medicine take it easy and resume the regular schedule of dosing. Do not take double doses.


Keep the medicine in a tightly sealed container that is kept at room temperature and away from moisture, heat, and sunlight. Be sure to keep the medicine from the medicine from freezing.

Keep away from the reach of children.

Avoid keeping outdated medicines or medications that are no longer needed.

Consult your physician about to tell you how to dispose of any medicine that you do not take.

Safety precautions when using Aggrenox

It is crucial to have your doctor examine your progress on a regular basis to ensure that the medicine is functioning properly and also to determine whether you need to continue to take it. It is possible to have blood tests to look for any unwanted side effects.

Utilizing this medication while you are pregnant may affect your baby’s unborn. Make sure you use a safe method for birth control in order to prevent from becoming pregnant. If you suspect you’ve been pregnant due to the medication, notify your doctor as soon as possible.

The combination of dipyridamole and aspirin provides greater protection against the development of blood clots, than any of the drugs used on their own. However bleeding risk can be elevated. To decrease the risk of bleeding

  • Avoid taking aspirin or any combination medication which contains aspirin with this medication unless the physician who prescribed it advises you to.
  • If you require a medication to treat pain or fever, your physician may not recommend taking more aspirin. It’s best to talk about this with your physician, so that you can know in advance what medication to take.

Lightheadedness, dizziness or fainting could be the result particularly when you rise from a sitting or lying position quickly. Slowly getting up can aid. If the problem persists or becomes worse, consult with your physician.

Beware of drinking alcohol when you take this medication.

Don’t take any other medication in the absence of discussing with your physician. This includes prescription and non-prescription (over-the-counter OTC) medicine, herbal and vitamin supplements.

Aggrenox side effects

In addition to its beneficial effects, some medicines may produce unwanted side negative effects. Although not all adverse effects can be present, if they do occur, they might require medical attention.

Talk to your doctor immediately If any of these negative side effects occur:

More commonly

Less popular

  • Leakage from the rectum
  • bleeding noses, bloody mucous or unanswered nasal bleeding
  • Bloody or black stool, black or tarry
  • confusion
  • convulsions (seizures)
  • trouble breathing
  • difficulties with speaking
  • double vision
  • inability to move legs, arms or facial muscles
  • inability to speak
  • memory loss
  • pale skin
  • spots of red or purple on the skin
  • Slow speech
  • Tightness in the chest
  • difficulty breathing (exertional)
  • unusual bleeding or bleeding that isn’t normal or
  • the vomiting of blood or a substance which resembles coffee grounds


  • Fullness in the stomach or abdominal area
  • Urine blood is stained with blood
  • chills
  • stool with a clay-colored color
  • The collection of blood beneath the skin
  • cough
  • deep, dark purple bruise
  • gaseous abdominal pain, stomach or gas.
  • itching and redness and swelling around the eyelid or the eyelid
  • Loss of appetite
  • nausea
  • loud breathing
  • A recurrent fever
  • Hives or skin rashes (severe)
  • Eyes that are watery
  • Skin or eyes with yellow eyes

Seek emergency assistance immediately If any of these signs of an overdose are present:

The signs of overdose

  • Vision blurred
  • continuous buzzing or ringing, or any other unidentified sound within the ears
  • dizziness, faintness or lightheadedness when rising abruptly from a sitting or lying in a seated
  • Heartbeats that are irregular or fast
  • flushes
  • hearing loss
  • insanity
  • sweating
  • unusual weakness or fatigue
  • A warm and cozy feeling

Certain side effects can be experienced which usually don’t require medical treatment. These symptoms may be eliminated after treatment, as your body is adjusting to your. Additionally your doctor could be able inform you how to prevent or lessen the effects of these adverse side effects. Consult your doctor in the event that any of these symptoms persist or become troubling or if there are any concerns regarding these:

More commonly

  • Acid or a sour stomach
  • Belching
  • diarrhea
  • problems in difficulty in
  • headache
  • heartburn
  • indigestion
  • Stiffness or muscle pain
  • inflammation, pain or redness of the joints
  • stomach discomfort or upset

Rare or less common

  • Back back pain
  • sensation of burning in the stomach or chest
  • Energy loss or strength
  • Retinal pain or swelling
  • Sleepiness or unusual tiredness
  • taste loss
  • Tenderness in the stomach region

Other adverse side effects that are that are not listed can also be seen in certain patients. If you observe any other side effects, you should consult with your physician.

Additional details

Always consult your doctor to make sure the information presented on this site is appropriate to your specific situation.


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