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Metoprolol Succinate vs Tartrate


Generical name: metoprolol 
The brand name:  Kapspargo Sprinkle, Lopressor, Toprol-XL
Drug class: Cardioselective beta-blockers

What is metoprolol?

Metoprolol Succinate vs Tartrate

Metoprolol Succinate vs Tartrate

Metoprolol is a beta-blocker which alters the heart as well as circulation (blood flows through veins and arteries).

This medication is used in the treatment of angina (chest pain) and hypertension (high blood pressure).


If you’ve suffered an attack on your heart or suffer from hypertension, then your physician might prescribe a medication such as metoprolol tartrate (Lopressor) or metoprolol succinate (Toprol XL). While both medications contain the same components, the active ingredient is different. They can be utilized in various ways.

Metoprolol tartrate, as well as metoprolol succinate, are part of a class of drugs referred to as beta blockers. They are often referred to by the names beta-1 selective adrenoceptor blocking drugs and beta antagonists.

The drugs block the hormones’ effects such as norepinephrine or epinephrine within the nervous system of the sympathetic. This system of the sympathetic nerve is the one responsible for the standard “fight-or-flight” response. Metoprolol may help ease pressure on the heart. It can also ease blood vessels to reduce the pressure of blood and relieve chest discomfort.


What are the primary distinctions between metoprolol succinate & metoprolol tartrate? 

The major distinction between metoprolol succinate and metoprolol tartrate is in their formulations. Metoprolol tartrate is an immediate release version of metoprolol, while metoprolol succinate has an extended release version. Metoprolol succinate is released slowly throughout the body, leading to more prolonged effects.

Metoprolol tartrate might require taking at least three times daily. Metoprolol succinate should be taken daily as it is longer-lasting than the tartrate version. Metoprolol succinate is also taken by children six years or older, whereas metoprolol tartrate is only taken by adults.


The conditions treated by metoprolol tartrate as well as metoprolol succinate

Both the tartrate as well as succinate variants of metoprolol are approved by FDA for treating the high pressure in blood vessels (hypertension) and chest pain (angina pectoris).

Metoprolol tartrate is FDA-approved as a treatment after a heart attack (acute myocardial infarction). Metoprolol tartrate taken after an attack on the heart can help lower the chance of having further heart attacks and deaths, particularly for patients with heart disease. The treatment should begin within 3-10 days after having suffered a heart attack.

Alongside high blood pressure as well as chest discomfort, metoprolol succinate is also FDA-approved for treating chronic heart disease. Particularly, metoprolol succinate treats chronic heart failure, which is classified as New York Heart Association class II or III. As a daily dose metoprolol succinate may enhance outcomes and reduce the chance of dying for patients suffering from heart failure.

Off-label uses for metoprolol comprise supraventricular tachycardia (abnormally high heartbeat) as well as thyroid storm (a risky condition that arises from an over-production of the hormone thyroid). Other off-label uses could include treating heart abnormal rhythm (arrhythmia) as well as the anxiety associated with performance.

Condition Metoprolol Tartrate Metoprolol Succinate
High blood pressure Yes Yes
Chronic chest pain in the chest Yes Yes
Acute heart attack Yes Off-label
Heart failure Off-label Yes
Supraventricular tachycardia Off-label Off-label
Thyroid storm Off-label Off-label
Arrhythmia Off-label Off-label
Anxiety about performance Off-label Off-label

Are metoprolol tartrate and metoprolol succinate more efficient?

Metoprolol tartrate as well metoprolol succinate both are alike in their effectiveness when it comes to managing high blood pressure and chronic pain in the chest. But metoprolol tartrate might be more effective for heart attacks that are acute, whereas metoprolol succinate might be more effective in treating chronic heart failure.

Clinical studies have demonstrated that metoprolol tartrate works for lowering blood pressure and preventing adverse consequences following heart attacks. However, research studies like Merit-HF have proven the effectiveness of metoprolol succinate. has superior results to metoprolol tartrate in the treatment of chronic heart failure.

Metoprolol succinate is a drug that can reduce the frequency of hospitalizations and even death due to heart failure. It is, however, carvedilol, another beta blocker that is commonly used could be more efficient than metoprolol succinate according to a study that was reported in Lancet.

Since metoprolol tartrate can be used multiple times during the day, the levels within the body may not be as constant. This could lead to greater adverse effects and less tolerance in comparison to the succinate extended-release form. One study discovered that adverse effects like a slow heartbeat (bradycardia) could be more likely when metoprolol tartrate is released immediately.


Cost and coverage comparison of metoprolol tartrate. metoprolol succinate

Metoprolol tartrate is available as a generic prescription drug which is typically covered by Medicare as well as other insurance plans. Without insurance, the median cost of metoprolol tartrate ranges from $5 to $5. SingleCare Discount cards can be utilized at participating pharmacies to cut down the price of this medication. It is possible to find a cost close to $4 when you use the savings coupon.

Metoprolol succinate, also known as extended-release metoprolol is a generic medicine that is covered by a variety of Medicare or insurance policies. Metoprolol succinate that is generic has a higher chance of being covered than brand generic Toprol XL. The cost of retail of the generic Toprol XL is around $56. Make sure to check with your pharmacist to determine if you are able to save money by using the single care card for savings. If you’re accepted, you’ll be able to lower the cost to $9.

Metoprolol Tartrate Metoprolol Succinate
Are insurance policies typically covered? Yes Yes
Most often included in Medicare? Yes Yes
Standard dosage 50 mg tablets 100 mg tablets
Typical Medicare copay $0-$65 $0-$20
Cost of SingleCare $4 $9


Common adverse effects of metoprolol tartrate as compared to. metoprolol succinate

The metoprolol tartrate, as well as the metoprolol succinate could produce similar side effects. The most commonly reported metoprolol side effects include dizziness or fatigue depression, shortness of breath (dyspnea) and an irregular beat (bradycardia). Other adverse consequences include nausea, diarrhea vomiting, dry mouth.

The hypersensitivity reaction, which can be characterized by itching or rash can also be experienced when taking either of metoprolol. According to the FDA label, metoprolol tartrate could have a higher likelihood to trigger certain side effects.

Metoprolol Tartrate     Metoprolol Succinate
Side Effect Applicable? Frequency Applicable? Frequency
Fatigue Yes 10% Yes >2%
Dizziness Yes 10% Yes >2%
Rash Yes 5% Yes >2%
Depression Yes 5% Yes >2%
Diarrhea Yes 5% Yes >2%
Shortness of breath Yes 3% Yes >2%
Slow heartbeat Yes 3% Yes >2%
Dry mouth Yes 1% Yes *not reported
Nausea Yes 1% Yes *
Heartburn Yes 1% Yes *
Constipation Yes 1% Yes *

Drug interactions with metoprolol tartrate against. metoprolol succinate

Metoprolol tartrate, as well as the metoprolol succinate, may interact with a variety of similar drugs. Other medications with similar effects or impact their metabolism in beta blockers may interact with both types of metoprolol.

Metoprolol should not be taken with catecholamine-depleting drugs. Combining these drugs can boost beta blockers’ effects and trigger adverse reactions like lower blood pressure ( hypotension) and a slower pulse (bradycardia). Other negative effects can include fainting, dizziness, and dizziness.

Metoprolol is extensively processed by its CYP2D6 enzyme. Thus, medications that block this enzyme could cause increased metoprolol levels inside the body. Metoprolol levels that are higher can increase the likelihood of adverse reactions.

Digoxin as well as other calcium channel blockers could have adverse effects when taken together with metoprolol. The combination of any of these drugs along with metoprolol could cause side reactions in the heart.


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Always consult your doctor to make sure the information presented on this site is appropriate to your specific situation.


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