Atropine Dose
Generic name: atropine
Brand name: AtroPen Auto-Injector, Sal-Tropine, AtroPen, Atreza
Dosage forms: injectable solution (0.05 mg/mL; 0.1 mg/mL; 0.4 mg/mL; 0.4 mg/mL-NaCl 0.9%; 1 mg/mL); intramuscular solution (2 mg/0.7 mL); intravenous solution (0.1 mg/mL; 0.4 mg/mL-NaCl 0.9%)
Drug class: Anticholinergic chronotropic agents, Anticholinergics/antispasmodics, Antidotes
Usual Adult Dose for Bradyarrhythmia
0.4 or 1 mg IV between 1 and 2 times per hour, as is
Higher doses, up to 2 mg, could be necessary.
Use: To treat severe syncope and bradycardia due to excessive carotid sinus hyperactivity
Usual Adult Dose for Anesthesia
0.4 mg up to 0.6 mg intramuscularly or subcutaneously
Comments:
Doses can be significantly over-extended in some instances.
Uses:
Treatment of parkinsonism, the tremor and rigidity are relieved by the allegedly selective depressant action
-Relieve hypertonicity, pylorospasm, and the small intestine, as well as hypermotility of the colon.
Reduce hypertonicity of the uterine muscle
Relax the spasms caused by colic in the ureter and biliary systems, as well as spasms in the bronchial duct.
Diminish the tone of detrusor muscles of the urinary bladder for treating urinary tract problems
Control the crying and laughing episodes in patients suffering from brain lesions.
Head injuries that are closed trigger the release of acetylcholine or to be found in cerebrospinal fluid, which can cause irregular EEG patterns, stupor, and neurological symptoms
Management of peptic ulcers
Anesthesia is used to reduce excessive salivation and secretions from the bronchial tract.
Control rhinorrhoea in acute rhinitis or hayfever
The antidote to pilocarpine, physostigmine isofluorphate, choline esters Certain Aminata species, and anticholinesterase insecticide poisoning.
-To reduce the severity of atrioventricular heart block. vagal tone increase is an important factor in the heart’s conduction defect, for example, in certain cases, due to digitalis¶
Usual Adult Dose for Anticholinesterase Poisoning
0.4 mg up to 0.6 mg intramuscularly or subcutaneously
Comments:
Doses can be significantly overextended in certain situations.
Uses:
Treatment of parkinsonism, stiffness, and tremor are alleviated by the allegedly selective depressant action
-Relieve hypertonicity and pylorospasm of the small intestine, as well as hypermotility in the colon.
Relieve hypertonicity in the uterine muscle
Relax the spasms of colic in the ureter and biliary systems, as well as the bronchial spasm
Diminish the tone of detrusor muscles of the urinary bladder during treatments for urinary tract problems
Control the crying and laughter episodes of patients suffering from brain lesions.
Closed head injuries that trigger the release of acetylcholine or to be present in the cerebrospinal fluid. This can lead to irregular EEG patterns, stupor, and neurological symptoms
Treatment of peptic ulcer
Anesthesia is used to reduce excessive salivation and secretions from the bronchial tract.
Control rhinorrhoea caused by acute rhinitis or hayfever
Antidote for pilocarpine isofluorphate, choline esters specific Aminata species, and insecticide poisoning caused by anticholinesterase.
-To reduce the severity of atrioventricular block in the heart when vagal tone increases are an important cause of the heart’s conduction defect, for example, sometimes due to digitalis
Usual Adult Dose for Rhinorrhea
0.4 mg up to 0.6 mg IV, intramuscularly or subcutaneously
Comments:
Doses can be significantly over-extended in some instances.
Uses:
Treatment of parkinsonism; the tremor and rigidity are relieved by the allegedly selective depressant action
-Relieve hypertonicity, pylorospasm and the small intestine, and hypermotility in the colon.
Relieve hypertonicity in the uterine muscle
Relax the spasms of colic in the ureter and biliary systems, as well as the spasms in the bronchial duct.
Reduce the tone of the detrusor muscles of the urinary bladder during treatments for urinary tract problems
Control the crying and laughter episode in patients suffering from brain lesions.
Head injuries that are closed result in the release of acetylcholine or to be present in the cerebrospinal fluid, which can cause irregular EEG patterns and stupor and neurological symptoms
Management of peptic ulcers
Anesthesia is used to reduce excessive salivation and secretions from the bronchial tract.
Control rhinorrhoea in acute rhinitis, hay fever, or acute rhinitis.
The antidote to pilocarpine, physostigmine isofluorphate, choline esters Certain Aminata mushroom species, and anticholinesterase insecticide poisoning.
-To lessen the amount of atrioventricular block in the heart when vagal tone increase is an important factor in the heart’s conduction defect, for example, sometimes due to digitalis
Usual Adult Dose for AV Heart Block
0.4 mg up to 0.6 mg intramuscularly or subcutaneously
Comments:
The dosages may be substantially overextended in certain situations.
Uses:
Treatment of parkinsonism; stiffness and tremor are alleviated through the apparent selective depressant action
-Relieve hypertonicity and pylorospasm of the small intestine and hypermotility in the colon.
Reduce hypertonicity of the uterine muscle
Relax the spasms caused by colic in the ureter and biliary systems, as well as the spasms in the bronchial duct.
Reduce the tone of the detrusor muscles of the urinary bladder during treating urinary tract problems
Control the crying and laughing episodes in patients suffering from brain lesions.
Head injuries that are closed result in the release of acetylcholine or to be present in the cerebrospinal fluid. This can lead to irregular EEG patterns, stupor, and neurological symptoms
Treatment of peptic ulcers
Anesthesia is used to reduce excessive salivation and bronchial secretions.
Control rhinorrhoea caused by acute rhinitis or hayfever
The antidote to pilocarpine, physostigmine isofluorphate, choline esters specific Aminata species, and anticholinesterase insecticide poisoning.
-To reduce the severity of atrioventricular heart block. vagal tone increases are one of the major causes for the heart’s conduction defect, for example, sometimes due to digitalis
Usual Adult Dose for Head Injury
0.4 mg up to 0.6 mg intramuscularly or subcutaneously
Comments:
The dosages may be substantially over-extended in some instances.
Uses:
Treatment of parkinsonism, stiffness, and tremor are alleviated by the allegedly selective depressant action
-Relieve hypertonicity and pylorospasm of the small intestine and the hypermotility of the colon.
Relieve hypertonicity in the uterine muscle
Relax the spasms of colic in the ureter and biliary systems, as well as the bronchial spasm
Diminish the tone of detrusor muscle in the urinary bladder during treatments for urinary tract problems
Control the crying and laughter episode in patients suffering from brain lesions.
Closed head injuries that trigger the release of acetylcholine or in cerebrospinal fluid can cause irregular EEG patterns, stupor, and neurological symptoms
Treatment of peptic ulcers
Anesthesia is used to reduce excessive salivation and secretions from the bronchial tract.
Control rhinorrhoea in acute rhinitis or hayfever
Antidote for pilocarpine isofluorphate specific Aminata species, and insecticide poisoning caused by anticholinesterase.
-To lessen the amount of atrioventricular heart block. vagal tone increases are a major cause of the defect in conduction, such as in certain cases, due to digitalis
Usual Adult Dose for Peptic Ulcer
0.4 mg up to 0.6 mg intramuscularly or subcutaneously
Comments:
The dosages may be substantially exceeded in certain situations.
Uses:
Treatment of parkinsonism; stiffness and tremor are alleviated by the allegedly selective depressant action
-Relieve hypertonicity and pylorospasm of the small intestine, as well as hypermotility of the colon.
Reduce hypertonicity of the uterine muscle
Relax the spasms of colic in the ureter and biliary systems, as well as the spasms in the bronchial duct.
Reduce the tone of the detrusor muscle in the urinary bladder for treating urinary tract problems
Control the crying and laughter episode in patients suffering from brain lesions.
Head injuries that are closed result in the release of acetylcholine or to be present in cerebrospinal fluid which can cause irregular EEG patterns and stupor and neurological symptoms
Treatment of peptic ulcer
In anesthesia to limit excessive salivation and bronchial secretions.
Control rhinorrhea caused by acute rhinitis or hayfever
The antidote to pilocarpine, physostigmine isofluorphate Certain Aminata species, and insecticide poisoning caused by anticholinesterase.
– To lessen the severity of atrioventricular heart block. vagal tone increases are an important cause of the defect in conduction, such as sometimes due to digitalis
Usual Adult Dose for Organophosphate Poisoning
0.8 mg. IM
If there is no visible effect after 30 minutes, or if certain poisoning symptoms develop (nausea diarrhea, vomiting, pupillary constriction, pulmonary edema facial arousal of the eyelids and tongue as well as jerky eye movements, over-sweating, excessive salivation, and the secretion of the bronchial tube) 2.25 mg IM every hour until symptoms of atropinization are observed.
The 2 mg dose could require to be administered at least 2 or 3 occasions (4 up to six mg in total) in the most severe of circumstances.
Auto-injector:
Two or more mild signs of exposure 2 mg dose
Severe symptoms: One dose of 2 mg and then two more 2 mg injections in rapid succession, 10 minutes after the initial dose.
or
Insomnia or severe symptoms: Three doses of 2 mg in the mid-lateral thigh in quick succession
Mild symptoms:
-Blurred vision, miosis
Eyes that are excessive and unexplained.
Unusual and excessively nasal runny
Increased salivation that is sudden, for example, unprovoked drooling that is not explained
The chest may be tight or there is difficulty breathing.
Trämors throughout the body or muscle Twitching
-Nausea and/or vomiting
Unexplained coughing or wheezing
-Acute start of stomach cramps
Tachycardia or bradycardia
The most severe symptoms are:
Unusual or confused behavior
The difficulty in breathing is severe or the airway or lungs.
General weakness
-Involuntary urination and/or defecation
-Convulsions
-Unconsciousness
Comments:
These doses can be significantly over-dosed in some instances.
Masks and protective clothing specially designed to protect from exposure to chemicals nerve agents as well as poisoning by insecticides should be worn for primary protection.
Patients shouldn’t rely only on the presence of drugs as a source of defense against chemical nerve agents and poisoning by insecticides.
The immediate evacuation of the affected environmental area is crucial.
Decontaminate the victim immediately if you can.
Auto-injectors should only be used by those who have received adequate training in the recognition and treatment of insecticide or nerve agent poisoning.
Pralidoxime chloride can be an important supplement to atropine therapy.
Auto-injectors are intended for the initial treatment for symptoms of muscarinic insecticide or nerve agent poisoning. Medical treatment is required immediately.
It is important to take action as soon as the symptoms of poisoning appear (usually tear, excess orifices, wheezing muscle fasciculations, and so on. ).
In cases of serious poisoning, the anticonvulsant can be given concurrently if the seizure is suspected in the patient who is not conscious because the tonic-clonic jerking that is typical is not always apparent because of how the poison affects the body.
It is recommended that three auto-injectors are available for every person who is at risk of being poisoned by nerve poisoning or organophosphate insecticide One is to treat mild signs, and two more injections for those with extreme symptoms. Don’t give more than three injections, unless under the supervision of trained medical professionals.
The administration of atropine without the presence of an actual poisoning by a nerve agent or insecticide could result in an overdose of atropine, which can cause short-term incapacitation (inability to walk normally, focus or think clearly for several or even more hours) Patients suffering from the cardiac disease are at risk of serious adverse events which could lead to death.
Applications: Treatment of poisoning due to organophosphorus nerve agent with Cholinesterase activity, and organophosphorus as well as carbamate insecticides.
Usual Adult Dose for Nerve Agent Poisoning
0.8 mg. I.M.
If there is no visible effect after 30 minutes, or if certain symptoms of poisoning occur (nausea vomiting and diarrhea, constriction of the pupil and pulmonary edema, facial swells of the tongue and eyelids as well as jerky eye movements, excess sweating and salivation, and secretion from the bronchial tract) 2.25 mg IM every hour until symptoms of atropinization are observed.
The dose of 2 mg may have to be administered three or more times (4 or 6 mg in total) in extreme circumstances.
Auto-injector:
Two or more mild signs of exposure Two mg dose
Severe symptoms The dose is 2 mg followed by two additional 2 mg injections in quick succession for 10 minutes after the initial dose.
or
The symptoms are severe or even unconscious. Three doses of 2 mg in the mid-lateral thigh, in rapid succession
Mild symptoms:
-Blurred vision, miosis
Excessive, unexplained tears
Unusual and excessively runny nose
Increased salivation that is sudden, for example inexplicably excessive drooling
Chest tightness or breathing difficulty
Tremors throughout the body, or muscle twitching
-Nausea and/or vomiting
Unexplained coughing or wheezing
-Acute beginning of stomach cramps
Tachycardia or bradycardia
Signs of severe illness:
Unusual or confusing behavior
Severe breathing difficulty or airway or lungs.
-Severe muscle twitching and general weakness
-Involuntary defecation and involuntary urine
-Convulsions
-Unconsciousness
Comments:
The doses could greatly overdose in some instances.
Protective clothing, such as masks specifically designed for protection against chemical nerve agents as well as poisoning by insecticides should be worn for primary protection.
Patients should not solely rely on the presence of drugs to provide defense against chemical nerve agents and poisoning by insecticides.
The immediate evacuation of the affected surroundings is vital.
Decontaminate the victim immediately if you can.
The auto-injector must be utilized by those who have received adequate training in the recognition and treatment of insecticide or nerve agent poisoning.
Pralidoxime chloride could be an important component of atropine therapy.
The auto-injector is designed to be the first treatment for muscarinic symptoms of insecticide or nerve agent poisoning. Medical attention must be sought out immediately.
It is important to take action as soon as the symptoms of poisoning develop (usually tears, excessive orifices, wheezing muscle fasciculations, etc. ).
In the case of severe poisoning, it is possible to use an anticonvulsant simultaneously administered if seizures are suspected in the patient who is not conscious since the typical tonic-clonic jerking might not be evident because of how the poison affects the body.
It is recommended that three auto-injectors should be available for each person who is at risk of being poisoned by nerve poisoning caused by organophosphate or organophosphate One to treat mild signs, then 2 additional injections for more extreme symptoms. Don’t administer more than 3 injections without being under the supervision of a medical professional who is trained.
The administration of atropine without the presence of poisoning by a nerve agent or insecticide could result in an overdose of atropine, which can cause temporary incapacitation (inability to walk or focus or think clearly for a period of several or more hours) Patients with heart disease are at risk of serious adverse events such as death.
Uses: Treatment for poisoning due to organophosphorus nerve agent with Cholinesterase activity, and organophosphorus as well as carbamate insecticides.
Usual Adult Dose for Radiographic Exam
1 mg 1 mg
Use for relaxation of the stomach as well as a colon in radiography
Usual Pediatric Dose for Anesthesia
Between 7 and 16 pounds 0.1 mg IV (IV), IV, or subcutaneously
17 to 24 lbs: 0.15 mg, IV or IM, or subcutaneously
24 to 40 lbs: 0.2 mg, IV (IM), subcutaneously, or IV
40-65 lbs: 0.3 mg, IV or IV, or subcutaneously
65 to 90 lbs: 0.4 mg, IV or IM or subcutaneously
For weights over 90 pounds, 0.4 or 0.6 mg IV, IM, or subcutaneously
Comments:
Doses can be significantly overextended in certain situations.
Uses:
-Relieve hypertonicity, pylorospasm, and the small intestine and hypermotility of the colon.
Reduce hypertonicity of the uterine muscle
Relax the spasms caused by colic of the ureter and biliary systems and bronchial spasms
Diminish the tone of detrusor muscles of the urinary bladder during treatments for urinary tract problems
Control the crying and laughing episodes in patients suffering from brain lesions.
Closed head injuries that result in the release of acetylcholine or to be found in cerebrospinal fluid, which can cause irregular EEG pattern, stupor, and neurological symptoms
Treatment of peptic ulcers
Anesthesia is used to reduce excessive salivation and bronchial secretions.
Control rhinorrhoea caused by acute rhinitis, hay fever, or chronic rhinitis.
Antidote for pilocarpine isofluorphate, choline esters specific Aminata mushroom species, and insecticide poisoning caused by anticholinesterase.
Treatment of parkinsonism; stiffness and tremor are alleviated by the allegedly selective depressant action
Usual Pediatric Dose for Anticholinesterase Poisoning
Seven to sixteen pounds 0.1 mg IV (IV), In the IM or subcutaneously
17 to 24 lbs: 0.15 mg, IV or IM, or subcutaneously
24 to 40 lbs: 0.2 mg, IV or IM, or subcutaneously
40 to 65 lbs: 0.3 mg, IV or In the IM or subcutaneously
65 to 90 lbs: 0.4 mg, IV or IM, or subcutaneously
For weights over 90 pounds, 0.4 up to 0.6 mg IV, IM, or subcutaneously
Comments:
The dosages may be substantially over-extended in some instances.
Uses:
-Relieve hypertonicity, pylorospasm, and the small intestine, as well as hypermotility in the colon.
Reduce hypertonicity of the uterine muscle
Relax the spasms caused by colic in the ureter and biliary tract and bronchial spasms
Reduce the tone of the detrusor muscles of the urinary bladder during treatments for urinary tract problems
Control the crying and laughing episodes in patients suffering from brain lesions.
Closed head injuries that trigger the release of acetylcholine or to be present in cerebrospinal fluid creating irregular EEG pattern, stupor, and neurological symptoms
Management of peptic ulcers
Anesthesia is used to reduce excessive salivation and bronchial secretions.
Control rhinorrhea caused by acute rhinitis, hay fever, or acute rhinitis.
The antidote to pilocarpine, physostigmine isofluorphate Certain Aminata species, and insecticide poisoning caused by anticholinesterase.
Treatment of parkinsonism, stiffness, and tremor are alleviated through the apparent selective depressant action
Usual Pediatric Dose for Bradyarrhythmia
Seven to sixteen pounds 0.1 mg/ml, IV or In the IM or subcutaneously
17 to 24 lbs: 0.15 mg, IV or IM, or subcutaneously
Between 24 and 40 pounds: 0.2 mg, IV, IV, or subcutaneously
40-65 lbs: 0.3 mg, IV or In the IM or subcutaneously
65-90 lbs: 0.4 mg, IV or in the IM or subcutaneously
More than 90 pounds 0.4 up to 0.6 mg IV, IM, or subcutaneously
Comments:
Doses can be significantly over-extended in some instances.
Uses:
-Relieve hypertonicity, pylorospasm, the small intestine, and the hypermotility of the colon.
Relieve hypertonicity in the uterine muscle
Relax the spasms caused by colic of the ureter and biliary systems and bronchial spasms
Diminish the tone of detrusor muscle in the urinary bladder during treating urinary tract problems
Control the crying and laughing episodes of patients suffering from brain lesions.
Head injuries that are closed trigger the release of acetylcholine or to be present in the cerebrospinal fluid, which can cause irregular EEG patterns and stupor and neurological symptoms
Management of peptic ulcers
In anesthesia to limit excessive salivation and secretions from the bronchial tract.
Control rhinorrhoea in acute rhinitis or hayfever
Antidote for pilocarpine isofluorphate specific Aminata species, and anticholinesterase insecticide poisoning.
Treatment of parkinsonism, the tremor and rigidity are relieved by the allegedly selective depressant action
Usual Pediatric Dose for Rhinorrhea
Seven to sixteen pounds 0.1 mg IV or IV, or subcutaneously
17 to 24 lbs: 0.15 mg, IV or IM, or subcutaneously
24 to 40 lbs: 0.2 mg, IV (IM), subcutaneously, or IV
40 to 65 lbs: 0.3 mg, IV, IV, or subcutaneously
65-90 lbs: 0.4 mg, IV or IM, or subcutaneously
More than 90 pounds 0.4 or 0.6 mg IV, IM, or subcutaneously
Comments:
Doses can be significantly over-extended in some instances.
Uses:
-Relieve hypertonicity, pylorospasm, and the small intestine, as well as hypermotility in the colon.
Reduce hypertonicity of the uterine muscle
Relax the spasms of colic in the ureter and biliary tract and bronchial spasms
Reduce the tone of the detrusor muscle in the urinary bladder for treating urinary tract problems
Control the crying and laughing episodes of patients suffering from brain lesions.
Head injuries that are closed result in the release of acetylcholine or to be found in cerebrospinal fluid, leading to irregular EEG patterns and stupor and neurological symptoms
Management of peptic ulcers
In anesthesia to limit excessive salivation and secretions from the bronchial tract.
Control rhinorrhoiditis in acute rhinitis or hayfever
Antidote for pilocarpine isofluorphate specific Aminata mushroom species and anticholinesterase insecticide poisoning.
Treatment of parkinsonism, stiffness, and tremor are alleviated by the allegedly selective depressant action
Usual Pediatric Dose for AV Heart Block
Between 7 and 16 pounds 0.1 mg IV (IV), IV, or subcutaneously
17 to 24 lbs: 0.15 mg, IV (IM), subcutaneously, or IV
24 to 40 lbs: 0.2 mg, IV (IM), subcutaneously, or IV
40-65 lbs: 0.3 mg, IV or IV, or subcutaneously
65-90 lbs: 0.4 mg, IV, in the IM or subcutaneously
More than 90 pounds 0.4 up to 0.6 mg IV, IM, or subcutaneously
Comments:
The dosages may be substantially over-extended in some instances.
Uses:
-Relieve hypertonicity and pylorospasm of the small intestine and hypermotility in the colon.
Reduce hypertonicity of the uterine muscle
Relax the spasms of colic in the ureter and biliary tract and bronchial spasms
Diminish the tone of detrusor muscle in the urinary bladder during treating urinary tract problems
Control the crying and laughing episodes of patients with brain lesions.
Head injuries that are closed result in the release of acetylcholine or to be present in the cerebrospinal fluid, leading to irregular EEG patterns and stupor and neurological symptoms
Treatment of peptic ulcer
Anesthesia is used to reduce excessive salivation and bronchial secretions.
Control rhinorrhea caused by acute rhinitis, hay fever, or chronic hayfever
The antidote to pilocarpine, physostigmine isofluorphate, choline esters Certain Aminata mushroom species, and insecticide poisoning caused by anticholinesterase.
Treatment of parkinsonism; the tremor and rigidity are relieved by the allegedly selective depressant action
Usual Pediatric Dose for Head Injury
Between 7 and 16 pounds 0.1 mg/ml, IV (IV), In the IM or subcutaneously
17-24 lbs: 0.15 mg, IV (IM), subcutaneously, or IV
24 to 40 lbs: 0.2 mg, IV or IM, or subcutaneously
40 to 65 lbs: 0.3 mg, IV or In the IM or subcutaneously
65-90 pounds: 0.4 mg, IV, Inject, or subcutaneously
For weights over 90 pounds, 0.4 or 0.6 mg IV, IM, or subcutaneously
Comments:
The dosages may be substantially exceeded in certain situations.
Uses:
-Relieve hypertonicity and pylorospasm of the small intestine and hypermotility in the colon.
Relieve hypertonicity in the uterine muscle
Relax the spasms caused by colic of the ureter and biliary systems and bronchial spasms
Diminish the tone of detrusor muscle in the urinary bladder for treatments for urinary tract problems
Control the crying and laughing episodes of patients suffering from brain lesions.
Head injuries that are closed trigger the release of acetylcholine or in cerebrospinal fluid creating irregular EEG patterns and stupor and neurological symptoms
Management of peptic ulcers
Anesthesia is used to reduce excessive salivation and secretions from the bronchial tract.
Control rhinorrhoea in acute rhinitis, hay fever, or acute rhinitis.
The antidote to pilocarpine, physostigmine isofluorphate specific Aminata mushroom species, and insecticide poisoning caused by anticholinesterase.
Treatment of parkinsonism, the tremor and rigidity are relieved by the allegedly selective depressant action
Usual Pediatric Dose for Peptic Ulcer
Seven to sixteen pounds 0.1 mg IV or IV, or subcutaneously
17-24 pounds: 0.15 mg, IV (IM), subcutaneously, or IV
Between 24 and 40 pounds: 0.2 mg, IV or IM, or subcutaneously
40 to 65 lbs: 0.3 mg, IV, IV, or subcutaneously
65-90 lbs: 0.4 mg, IV or in the IM or subcutaneously
For weights over 90 pounds, 0.4 up to 0.6 mg IV, IM or subcutaneously
Comments:
The dosages may be substantially over-extended in some instances.
Uses:
-Relieve hypertonicity and pylorospasm of the small intestine and hypermotility in the colon.
Relieve hypertonicity in the uterine muscle
Relax the spasms of colic of the ureter and biliary systems and bronchial spasms
Diminish the tone of detrusor muscles of the urinary bladder during treatments for urinary tract problems
Control the laughing and crying episodes of patients suffering from brain lesions.
Closed head injuries that trigger the release of acetylcholine or in the cerebrospinal liquid, which can cause irregular EEG pattern, stupor, and neurological symptoms
Management of peptic ulcers
Anesthesia is used to reduce excessive salivation and secretions from the bronchial tract.
Control rhinorrhoea caused by acute rhinitis, hay fever, or chronic hayfever
Antidote for pilocarpine isofluorphate, choline esters specific Aminata species, and anticholinesterase insecticide poisoning.
Treatment of parkinsonism, stiffness, and tremor are alleviated by the allegedly selective depressant action
Usual Pediatric Dose for Organophosphate Poisoning
Auto-injector:
Children who weigh more than 90 pounds 2 mg dose
40-90 lbs 1 mg dosage
15 to 40 lbs: 0.5 mg dose
Under 15 pounds 0.25 mg dosage (bunch up to the thigh for the injection with a larger area)
Two or more mild signs of exposure One dose (see the weight guide in the previous paragraph)
Signs of severe symptoms The first dose was then two doses administered quickly, in rapid succession for 10 minutes after the first dose.
or
The symptoms are severe or even unconscious. Three doses in the mid-lateral thigh, in rapid succession
Mild symptoms:
-Blurred vision, miosis
Excessive, unexplained tears
Unusual and excessively runny nose
Increased salivation that is sudden, for example inexplicably excessive drooling
The chest may be tight or there is difficulty breathing.
Tremors throughout the body, or muscle twitching
-Nausea and/or vomiting
Unexplained coughing or wheezing
-Acute beginning of stomach cramps
Tachycardia or bradycardia
Signs of severe illness:
Unusual or confused behavior
Severe breathing difficulty or exudations from the airway/lungs
-Severe muscle twitching and general weakness
-Involuntary defecation and urination
-Convulsions
-Unconsciousness
Comments:
These doses can be significantly exceeded in some cases.
Protective clothing, such as masks specially designed to protect against chemical nerve agents as well as poisoning with insecticides, must be worn for the first line of defense.
Patients should not solely rely on the presence of drugs to provide protection against chemical nerve agents and poisoning with insecticides.
It is imperative to remove the affected surroundings is vital.
Decontaminate the victim immediately if you can.
Auto-injectors should only be used by people who have been trained in the recognition and treatment of the symptoms of insecticide or nerve agent intoxication.
Pralidoxime chloride can be an important component of atropine therapy.
The auto-injector is designed to be the first treatment for muscarinic symptoms of insecticide or nerve agent poisoning. Expert medical attention is required immediately.
It is important to take action as soon as the symptoms of poisoning appear (usually tears, excess orifices, wheezing muscle fasciculations, and so on. ).
In the case of severe poisoning, it is possible to use an anticonvulsant simultaneously administered if seizures are suspected in the patient who is not conscious since the typical tonic-clonic jerking might not be evident because of how the poison affects the body.
It is recommended that three auto-injectors should be available for each person who is at risk of being poisoned by a nerve agent or organophosphate poisoning One in case of mild symptoms then 2 additional injections for more extreme symptoms. Don’t administer more than 3 injections without being under the supervision of a trained medical professional.
In the absence of poisoning from a nerve agent or insecticide could result in an overdose of atropine, which can cause short-term incapacitation (inability to walk normally, focus or think clearly for a period of several or more hours) Patients suffering from the cardiac disease are at risk of serious adverse events such as death.
Treatment of poisoning due to organophosphorus nerve agents that have Cholinesterase activity, and organophosphorus as well as carbamate insecticides.
Usual Pediatric Dose for Nerve Agent Poisoning
Auto-injector:
Children who weigh more than 90 pounds 2 mg dose
40-90 lbs 1 mg dosage
15-40 lbs: 0.5 mg dose
Weightless than 15 pounds 0.25 mg (bunch up to the thigh for an area that is denser for injection)
Two or more mild signs of exposure One dose (see the weight guide above)
Signs of severe symptoms A single dose is followed by two doses that are administered in rapid succession, 10 minutes after the first dose.
or
The symptoms are severe or even unconscious. Three doses of the mid-lateral thigh, in rapid succession
Mild symptoms:
-Blurred vision, miosis
Excessive, unexplained tears
Unusual and excessively runny nose
Increased salivation that is sudden, for example inexplicably excessive drooling
Chest tightness or breathing difficulty
Trämors throughout the body or muscle Twitching
-Nausea and/or vomiting
Unexplained wheezing or coughing
-Acute start of stomach cramps
Bradycardia or tachycardia
Signs of severe illness:
Unusual or confused behavior
Severe breathing difficulty or exudations from the airway/lungs
General weakness
-Involuntary defecation and urination
-Convulsions
-Unconsciousness
Comments:
The doses could greatly overdose in some instances.
Protective clothing, such as masks specifically designed for protection from exposure to insecticide and chemical nerve agent poisoning must be worn to protect yourself.
Patients shouldn’t rely only on the presence of drugs to provide defense against chemical nerve agents and poisoning with insecticides.
It is imperative to remove the affected surroundings is vital.
Decontaminate the person who was poisoned as quickly as is possible.
Auto-injectors should only be used by people who have been trained in the recognition and treatment of insecticide or nerve agent poisoning.
Pralidoxime chloride can be an important supplement to atropine therapy.
The auto-injector is designed to be an initial treatment for symptoms of muscarinic insecticide or nerve agent poisoning. Medical attention is required immediately.
It is important to take action as soon as the symptoms of poisoning appear (usually tear, excess orifices, wheezing muscle fasciculations, and so on. ).
In cases of serious poisoning, the anticonvulsant can be simultaneously administered if seizures are suspected in the person who is unconscious since the typical tonic-clonic jerking is not always apparent because of how the poison affects the body.
It is recommended that three auto-injectors are available for every person who is susceptible to organophosphate or nerve agent poisoning: one to treat mild signs, then 2 additional injections for more extreme symptoms. Don’t administer more than three injections, unless under the supervision of a trained medical professional.
The administration of atropine without the presence of an actual poisoning by a nerve agent or insecticide can result in an excessive dose of atropine, which can cause short-term incapacitation (inability to walk normally, be able to think or see clearly for more than a few hours) Patients with heart illness are at risk for serious adverse reactions which could lead to death.
Use: Treatment for poisoning due to organophosphorus nerve agent with the ability to cleave and release cholinesterase and organophosphorus as well as carbamate insecticides.
Renal Dose Adjustments
Information is are not available
Liver Dose Adjustments
Information is are not available
Precautions
A cautious approach is suggested when taking atropine for older patients due to the increased risk of adverse negative effects. The elderly are more susceptible to the effects of anticholinergic that atropine has on the CNS that could cause anxiety, confusion, delirium, or drowsiness.
The primary safeguard against the exposure of chemical nerve agents or insecticides is the wear of protective clothes, such as masks that are specifically designed for this purpose. It is not enough to rely on the availability of antidotes such as atropine for full protection from the chemical poisoning from insecticides or nerve agents.
Dialysis
Atropine cannot be removed completely through hemodialysis.
Additional details
Always consult your doctor to make sure the information presented on this page is applicable to your specific situation.