Generic Name: dextroamphetamine

Dosage Form: transdermal system

Medically reviewed by A Ras, MD.  Updated on April 5, 2022.

What is Xelstrym?

Xelstrym is an atypical central nerve system (CNS) stimulant prescription medication that is used to treat Attention Deficit Hyperactivity Disorder (ADHD) in adults and children aged 6 years old and over. It can help improve concentration and reduce impulsivity as well as hyperactivity in adults and children 6 years old or older who have ADHD.

It is not clear whether this medication can be used safely and effectively for children younger than 6 years old. age.

The Xelstrym drug is a federally controlled substance (CII) since it is a source of dextroamphetamine which is an ideal target for those who misuse prescription medications and street drugs. Make sure to keep Xelstrym in a secure place to guard it against theft. Don’t give it away to anyone else because it could cause harm or death. Giving away or selling Xelstrym could harm other people and is in violation of the law.

Xelstrym (dextroamphetamine) transdermal system, contains dextroamphetamine, a CNS stimulant. Dextroamphetamine is the dextro isomer of the compound d,l-amphetamine. The chemical name for dextroamphetamine is (2S)-1-phenylpropan-2-amine. It is a clear to slightly amber-colored liquid. The molecular weight of dextroamphetamine is 135.21 g/mol and the molecular formula is C9H13N.



Xelstrym is provided in four strengths: 4.5 mg/9 hours, 9 mg/9 hours, 13.5 mg/9 hours, and 18 mg/9 hours. The composition per unit area of all dosage strengths is identical. Inactive ingredients include acrylic adhesives, green ink, polyester/polyurethane backing, and polyester release liner.

Mechanism of Action

Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. The exact mode of therapeutic action in ADHD is not known.

Important information

Xelstrym could have serious side effects which include:

Your healthcare provider should be able to check you or your child for heart conditions prior to starting treatment. Discuss with your healthcare professional whether the child or you has any heart issues, heart problems, high blood pressure, or ancestry of any of these issues.

Your doctor should be checking your child’s or your own heart rate and blood pressure frequently throughout treatment.

Consult your physician or visit the nearest emergency room in a hospital immediately If the child or you shows any symptoms of heart trouble like chest discomfort, breathlessness, or fainting in treatment.

Talk to your healthcare provider about any mental health issues you or your child may be suffering from or about a family history of bipolar disorder, suicide, or depression.

Contact your healthcare professional immediately if you or your child are experiencing any new or more severe mental issues or signs while receiving treatment, including hearing voices, believing or seeing things that aren’t real, or new manic symptoms.

Warnings and precautions

Who shouldn’t use Xelstrym?

Do not use Xelstrym in the event that either of you:

Before using Xelstrym

Before starting treatment, inform your healthcare professional about all health conditions, including the following if either you or your children

What other drugs can have an effect on Xelstrym?

Inform your doctor about every medication the child or you are taking for both prescription and over-the-counter medications as well as vitamins and herbal supplements.

It could alter the way other medicines function and other medicines could impact how Xelstrym performs. Utilizing Xelstrym in conjunction with other medications could result in serious side consequences. In some cases, the dosages of other medicines may need to be altered.

Tell your doctor whether either of you takes:

Your doctor will determine whether Xelstrym should be used in conjunction with other medications. Don’t begin any new treatment without consulting your healthcare professional first.

How can Xelstrym be utilized?

When you suspect that your child or you consume excessively Xelstrym contact your physician or poison control at 1-800-222-1222 or visit the nearest emergency room in a hospital immediately.

Dosing information

The Usual Adult Dosage of ADHD

A recommended dose for starting for 9 mg per 9 hours. The maximum dose that is recommended is 18 mg/9 hour.

Use for treatment for Attention Deficit Hyperactivity Disorder (ADHD) for adults

Usual Dosage for Children with ADHD

A recommended dose for starting of 4.5 mg/9 hours. The dosage should be divided into weekly increments of 4.5 mg until a maximum dose that is 18 mg/9hrs

Use: Treatment for ADHD or Attention Deficit Disorder (ADHD) within infant patients (6 to 17 years old)

What should I be aware of when using Xelstrym?

Xelstrym side effects

Xelstrym could have serious side effects which include:

Inform your doctor whether either you or your children suffer from an ache, numbness or color changes, or sensitivity to temperature changes in your toes or fingers.
Contact your healthcare professional immediately if your child shows any indications of wounds that are not explained appearing on your fingers or toes while receiving treatment.

The most commonly reported adverse effects are:

There are many possible adverse side negative effects. Consult your physician to get medical advice on adverse effects. You can report symptoms to FDA at 1-800-FDA-1088.

How do I keep Xelstrym in my storage?

Make sure that all medications are away from pets and children.

General information regarding the safe and efficient application of Xelstrym.

Some medicines are used for reasons other than those mentioned in the Medication Guide. Don’t use this medication for any medical condition for which it is not recommended. Don’t give it to others regardless of whether they are suffering from the same symptoms as you do. They could be harmed and is against the law. You may consult your doctor or pharmacist for advice that has been designed for healthcare professionals.

What are the ingredients of the Xelstrym?

Active ingredient: dextroamphetamine
Inactive ingredients: acrylic adhesives, green ink, polyester/polyurethane backing, and polyester release liner

Instructions For use

Xelstrym Instructions for Use contains information on how to apply, remove, and dispose of XELSTRYM transdermal system (patch).

XELSTRYM transdermal system (patch) is for use on skin only.

Read these Instructions for Use before you start using XELSTRYM and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your or your child’s medical condition or treatment.

XELSTRYM is supplied in cartons containing 30 patches. Each patch is sealed in a pouch protecting it until you are ready to apply it.

Important information you need to know before applying XELSTRYM:

Xelstrym Instructions For use

                                                                               Figure A



Step 1: Select the patch application site (see

Figure B).

  • Choose 1 application site, on either the left or right side, to apply 1 patch

o    chest

o    upper arm

o    upper back

o    flank (sides of the waist)

o    hip


  • Avoid areas of tight clothing, such as waistbands or straps.
  • Choose a different application site from the one used the previous day when you apply a new patch.
  • Check the expiration date before applying the patch.

Figure B


Step 2: Check the skin where XELSTRYM will be applied. Make sure it is:

●        Not damaged (cut, scraped, burned), irritated (rashes), or has any other skin problems

●        Dry (not wet) and clean, with no powder, oil, lotion, or gel


●        Hairless or nearly hairless

If there is hair at the patch application site, do not shave the application site. Use scissors to clip hair as close to the skin as possible.

Step 3: Applying XELSTRYM

●  Carefully cut the pouch using scissors along the dashed line marked “Cut Here” (see Figure C).


●  Gently remove the contents of the pouch and throw away the additional pieces of film above and below the

patch (see Figure A, Figure D).

○  Do not use the patch if it is cut or damaged

○  Apply the patch right away after removing it from the pouch


●  Gently peel away half of the clear plastic liner. Avoid touching the sticky side with your fingers (see Figure E).


● Apply the sticky side of the patch to the application site you selected and smooth it down (see Figure F).




● Hold the edge of the remaining protective liner, slowly peel it off and smooth the patch down (see Figure G).

● Press the patch firmly with the palm of your hand.

● Smooth the patch to make sure it sticks well to your skin (See Figure H).


XELSTRYM patch should not be applied or reapplied with dressings, tape, or other adhesives.




●  Wash your hands with soap and water after applying the patch (see Figure I).

Hand sanitizer should not be used in place of soap and water.


Figure I


Step 4: Check XELSTRYM regularly during the day to make sure it is completely sticking to the application site. Also check the patch when:

○      using the bathroom                                          ○    undressing or changing clothes

○      after sleeping                                                  ○    if sweating a lot

○      after bathing, showering or swimming

●      If patch edges lift, smooth the patch down on the skin and press firmly with the palm of your hand. XELSTRYM patch should not be reapplied with dressings, tape, or other adhesives.

●      If the patch falls off, do not reapply the same patch. Fold the patch in half so that the sticky sides are together and throw away the patch as instructed below in Steps 5 to 7. You may apply a new patch to a different application site. The total wear time for the first patch that fell off and the second replacement patch should not be more than a total of 9 hours in 1 day (24 hours).

●      Parents or caregivers of children prescribed XELSTRYM should instruct the child to tell an adult if the patch becomes loose or falls off.


XELSTRYM Application Schedule for 9 Hour Wear Time:

If you put the patch on at: On the same day, remove the patch no later than:
6:00 a.m. 3:00 p.m.
7:00 a.m. 4:00 p.m.


8:00 a.m. 5:00 p.m.
9:00 a.m. 6:00 p.m.
10:00 a.m. 7:00 p.m.
11:00 a.m. 8:00 p.m.
12:00 p.m. 9:00 p.m.


Removing and Disposing Used XELSTRYM:



Step 5: After 9 hours, remove XELSTRYM and fold it in half so that the sticky sides stick together (see Figure J) to avoid accidental exposure to medicine.

●  If any adhesive (glue) remains on your skin after you remove the patch, apply an oil- based product or water and soap to the skin to remove the glue.


Figure J

Step 6: Throw away the used patch in a container with a lid right away (see Figure K).  

Figure K


Step 7: Wash your hands with soap and water after throwing the patch away (see Figure L).

Hand sanitizer should not be used in place of soap and water.

Figure L


Disposing of unused XELSTRYM:

Dispose of remaining unused or expired XELSTRYM by a medication take-back program at authorized collection sites such as retail pharmacies, hospital or clinic pharmacies, and law enforcement locations. If no take-back program or authorized collector is available, each unused patch should be removed from its individual pouch, separated from the protective liner, folded in half, and disposed of in the same manner as used patches.

More details

Always consult your doctor to make sure the information presented on this page is applicable to your particular situation.


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