Jump To



Generically: Buprenorphine as well as Naloxone (sublingual tablet) 
The brand name:  Zubsolv
Classification of drugs: Narcotic analgesic combinations


What is Zubsolv?


Zubsolv sublingual tablets have buprenorphine as well as the drug naloxone. Buprenorphine is an opioid drug that is sometimes referred to as a drug called a narcotic. Naloxone can block the effects of opioids such as pain relief and feelings of happiness that could result in the abuse of opioids.

Zubsolv is utilized to treat addiction to opioids.

Zubsolv is not allowed to be used for pain relief.



Zubsolv may slow or stop your breathing. It could also cause you to develop a habit. The misuse of Zubsolv can result in addiction, overdose, or even death, especially for children or any other person who is taking the medicine without the prescription.

The use of Zubsolv during pregnancy could result in life-threatening withdrawal symptoms for the infant.

Side effects that are fatal can occur when you use Zubsolv in combination with alcohol or with other medications that can cause drowsiness or slow breathing.


Before taking this medication, you must consult your physician

The use of Zubsolv is not recommended If you have an allergy to buprenorphine and naloxone (Narcan).

To ensure that Zubsolv is suitable for you, ask your doctor if ever experienced:

  • breathing issues sleep apnea
  • Prostate enlargement, urinary issues;
  • kidney or liver disease
  • spinal curvature that is abnormal that can affect breathing
  • problems with your gallbladder thyroid gland, or adrenal gland;
  • an injury to the head, seizures, brain tumor or
  • Alcoholism or addiction to drugs.

If you take opioid medication while pregnant, your child may develop a dependence on the medication. This can cause dangerous withdrawal symptoms in the newborn after it’s born. Infants who become dependent on opioids might require medical attention for a few weeks.

Consult a physician before taking opioids if you are nursing. Tell your doctor in case you notice a sudden increase in fatigue or a slow breathing rate for your baby.

How to take  Zubsolv?

Utilize Zubsolv precisely as prescribed by your physician. Follow the instructions on your prescription label and go through the entire medication guide. Do not take Zubsolv in greater amounts or for longer than the time prescribed. Talk to your doctor if have a strong urge to use the medication.

Don’t share opioids with anyone else, particularly one who has a history of substance abuse or addiction. A misusing of the medicine can cause addiction, OVERDOSE, OR DEATH. Place the medication at a safe place so that others are unable to access it. Giving away or selling opioid medicines is illegal.

Take note of and follow the Instructions for Use that are included in your medication. Consult your physician or pharmacist for clarification if you are unsure of the instructions.

Zubsolv is sold in a blister pack that includes the blister unit of 10. Each blister includes 1 Zubsolv tablet. Separate one single blister unit by cutting along the perforations until completely separate. Then fold the unit in the direction of the dotted line. Don’t press the Zubsolv tablets into the foil because this could cause the tablet to break.

Hands should be dry for working with Zubsolv Sublingual Tablets. Place the tablet sublingually under your tongue. Let the tablet dissolve slowly. Don’t consume the tablet in its entirety.

If you change between medications with buprenorphine in them, you should not take the exact dose for each. Be sure to follow the directions.

Don’t stop taking Zubsolv in a hurry or you may experience painful withdrawal signs. Consult your physician about how you can effectively stop taking this medication.

You’ll need regular blood tests to monitor your liver’s functioning.

All of your medical providers should be aware that you’re being treated for an addiction to opioids and that you are taking Zubsolv. Make sure that your family members are aware of what information to give should they need to contact you in an emergency.

Never break or crush the Zubsolv sublingual tablet. Inhale the powder, or mix it with liquid and inject it into the vein of yours. This has led to the death of a patient.

Storage Zubsolv safely in the Original blister package at room temperature and away from heat and moisture. Throw away a blister that is empty in a safe place that pets and children are not able to access. Keep track of the medication. You must be aware if you are using the medicine improperly or without a prescription.

Don’t keep any empty bottles of opioids. A single dose can cause death in someone taking Zubsolv in error or incorrectly. Ask your pharmacist for a disposal program that takes back the drug. If there isn’t a take-back program available, take any tablets that are no longer needed from the blister packs and flush them into the toilet. Toss the blister pack that is empty in the garbage.

Dosing information

Usual Adult Dose for Opiate Dependence – Induction:

INDUCTIONS: For people who depend on Heroin, or any other short-acting Opioid Products:
Initial DOSES must begin as soon as evident signs of moderate withdrawal from opioids are observed and not less than six hours after the time when the patient last took opioids in order to prevent the onset of the opioid withdrawal symptoms

Zubsolv Sublingual Tablets:
Day 1 Up the amount of 5.7 mg/1.4 mg administered sublingually give an initial dose of 1.4 mg/0.36 mg. After that, all the way up to 4.2 mg/1.08 mg. The dose should be divided into doses of 1.4 mg/0.36 mg, and 2.8 mg/0.72 mg. The dose should be taken at 1.5 to 2 hours intervals (some patients who have had recent exposure to buprenorphine might accept a single dosage of 4.2 mg/1.08 mg)
Day 2: 11.4 mg/2.9 mg sublingually in one dose

-Patients dependent on heroin or other short-acting opioid products may be inducted with combination buprenorphine/naloxone or buprenorphine monotherapy; to avoid precipitating withdrawal during induction, initiation should occur when clear signs of withdrawal are evident, preferably when moderate objective signs of opioid withdrawal appear, and no sooner than 6 hours after last use of heroin or other short-acting opioid.

In some studies, too gradual induction for a long period of time can result in a significant rate of discontinuation; it is suggested that a dose of treatment appropriate adjusted to achieve clinical effectiveness be obtained as fast as is possible.

If a patient is dependent on methadone or other long-acting opioids, buprenorphine alone should be utilized during the induction period as the drug may be absorbed only in small quantities and can cause withdrawal or delay it during the induction.
Maintenance treatment starts on the 3rd day of the month.

Usual Adult Dose for Opiate Dependence – Maintenance:


-Doses of buprenorphine/naloxone should be adjusted to a level that holds the patient in treatment and suppresses opioid withdrawal signs and symptoms; doses should be titrated to clinical effectiveness as rapidly as possible as gradual titration may lead to higher drop-out rates.

Zubsolv Sublingual Tablets:
-Progressively adjust in increments/decrements of 1.4 mg/0.36 mg or 2.9 mg/0.71 mg to a level that holds the patient in treatment and suppresses opioid withdrawal signs and symptoms
The recommended dose is 11.4 mg/2.9 mg administered sublingually taken once per day. Dose vary from 2.9 mg/0.71 mg up to 17.2 mg/4.2 mg
-Maximum dose: 17.2 mg/4.2 mg per day

Following the induction process treatment, maintenance therapy is offered to maintain a patient’s treatment and reduce opioid withdrawal symptoms and signs. There is no recommended maximum time frame for maintenance therapy and certain patients might require therapy for an indefinite period of time.
-There are multiple buprenorphine/naloxone products available for maintenance treatment; these products are not bioequivalent and dose adjustments may be necessary when switching products; e.g., Zubsolv 4.2 mg/0.7 mg buccal film provides equivalent buprenorphine exposure as Suboxone 8 mg/2 mg sublingual tablet.

Use: To treat of addiction to opioids within a comprehensive treatment program that includes psychosocial counseling and support.

If I do not take a dose?

You should take the medication as quickly as you are able, but avoid your missed dosage if it’s close to the time of the next dose. Don’t have two doses in one time.

How do I react if take too much?

For medical emergencies, seek immediate medical attention or contact the Poison Help line at 1-800-222-1222. An overdose of opioids could cause death, especially in the case of a child or another person who is taking the medication without a prescription. Overdose symptoms may include extreme drowsiness and numbness of pupils, slow breathing, or not breathing.

What should I be aware of when taking Zubsolv?

Don’t drink alcohol. Dangerous side effects or even death could happen.

Avoid operating machinery or driving until you are aware of what the effects of this medicine are on your body. Drowsiness or dizziness can result in accidents, falls, or even serious injuries.

Zubsolv side effects

See a doctor immediately Get medical attention immediately if you show symptoms for an allergy reaction Zubsolv such as difficulty breathing; hives; swelling of your lips, face, or tongue.

Opioid medicines can cause breathing to slow or cease and even cause death. The person who is caring for you must seek urgent medical care if you suffer from prolonged breathing, pauses in your breathing, and blue-colored lips or if it is difficult to get back up.

Contact your doctor immediately or seek medical attention in an emergency in the event of:

  • Breathing is the weak or shallow breath that ceases during sleeping;
  • a euphoric feeling, similar to you is about to pass out.
  • disorientation, lack of coordination in extreme weakness;
  • blurred vision, speech blurred,
  • liver issues – stomach pain, inability to eat dark urine, clay-colored stool jaundice (yellowing of the eyes or skin);
  • Serotonin levels are high within the body which causes hallucinations, agitation and sweating. shaking, rapid heart rate and muscle stiffness Twitching, loss coordination nausea, vomiting diarrhea;
  • low levels of cortisol nausea, vomiting, loss of appetite, dizziness, or worsening fatigue or weakness;
  • the symptoms of withdrawal from opioids are shivering, goose bumps, sweating more and feeling cold or hot and runny eyes, watery nose cramps in the muscles.

Breathing problems that are serious could be more common in older adults and those with debilitating conditions or suffer from wasting syndrome, or chronic breathing conditions.

Common Zubsolv side effects can include:

  • blurred vision dizziness, feeling drunk, difficulty concentration;
  • withdrawal symptoms;
  • discomfort, redness, or numbness in your mouth;
  • nausea, vomiting, constipation;
  • Back pain, headaches,
  • Heartbeats that are fast or rapid, more sweating; or
  • sleep problems (insomnia).

This isn’t an exhaustive list of all side effects. other side effects could occur. Contact your doctor to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

What other drugs can be affecting Zubsolv?

There is a possibility of breathing issues or withdrawal symptoms if discontinuing or change the dosage of various other medications. Inform your doctor if also take an antibiotic, antifungal medicine as well as blood pressure or heart medications, seizures medication or medication to treat HIV or Hepatitis C.

Opioid medications may interact with other drugs, causing serious side effects or even death. Be sure your doctor is aware of if you are taking:

  • medications for allergies or colds or bronchodilator asthma/COPD medications or a diuretic (“water pill”);
  • medicine to treat motion sickness or irritable bowel syndrome or an overactive bladder.
  • different opioids – pain medication for opioids and prescription medicine for cough
  • a sedative similar to Valiummore – diazepam alprazolam lorazepam, Xanax, Klonopin, Ativan, and others;
  • substances that cause you to feel sleepy or cause breathing to slow A sleeping pill, a muscle relaxer, or medicine for treating mental illnesses or mood disorders or
  • medications that alter serotonin levels within your body as a stimulant or medication for Parkinson’s disease, depression, chronic infections, migraine headaches or vomiting, and nausea.

The list below is not comprehensive. Other medications can be incompatible with buprenorphine or Naloxone, such as medications that are prescribed and available over the counter such as vitamins, herbal remedies. There are many possible interactions that are not mentioned here.

Alternatives to Zubsolv

Alternative drugs are available in various forms that can be used to treat addiction disorders caused by opioids.

Consult your physician to determine which one is most suitable for you.


  • IM injection (Sublocade), Implant (Probuphine), Sublingual (Subutex)

Naloxone and Buprenorphine

  • Sublingual (Bunavail, Suboxone)



  • Tablets (Dolophine)


  • IM injection (Vivitrol), Naltrexone tablets

In the event of an opioid overdose, when in urgent situations:


  • Nasal spray (Narcan, Kloxxado), Naloxone injection

Other medicines that are related to them:

Buprenorphine for extreme pain:

  • IM injection (Buprenex), Sublingual (Belbuca), Transdermal patch (Butrans)

Read Next Article

PHP Code Snippets Powered By : XYZScripts.com