Generical name: ribociclib
The brand name is Kisqali
Drug class: CDK 4 / 6 inhibitors
What is Kisqali?
Kisqali ( ribociclib) is a cancer treatment which blocks the spread and growth of cancerous cells within the body.
Kisqali will treat hormonal-related breast cancers that are caused by hormones for women. Ribociclib is only used in cases where your cancer has been found to be positive for a protein known as the Human epidermal growth factor receptor (HER2). The HER2 protein could speed up the growth of cancerous cells.
Kisqali is used when cancer has advanced or expanded to other parts of the body following other treatments.
Kisqali could cause severe side effects to your liver, heart, or lung. Call your doctor immediately if you experience chest pain, rapid or beating heartbeats or breathing problems and cough (with or without mucus) or abrupt dizziness or right-sided stomach discomfort and loss of appetite. unusual bleeding or bleeding, dark urine or the appearance of yellowing on your skin or eyes.
You’ll require regular medical examinations while taking Kisqali. The treatments for cancer could be delayed based on the findings of these tests. Consult your physician if you notice signs of infection such as chills or fever.
Before taking this medication, you must consult your physician
It is not recommended to make use of Kisqali If you are allergic to ribociclib, or you are also taking Tamoxifen.
The doctor will conduct blood tests to confirm that there are no problems that make it unsafe for you to use Kisqali.
To ensure Kisqali is suitable for you, ask your physician if you’ve previously had:
- Slow heartbeats;
- heart disease or an earlier heart attack
- long QT syndrome;
- An electrical imbalance (such as low concentrations of magnesium, calcium the mineral phosphorus or potassium present in the blood);
- the liver condition;
- kidney disease or
- indicators of signs of infection (fever signs of infection (fever).
Discuss with your doctor if you’ve experienced menopausal symptoms..
It is possible that you will need to take an unfavourable pregnancy test prior to commencing this treatment.
Do not take Kisqali when you are pregnant. It could harm the unborn baby. Make sure you use effective Birth Control to avoid pregnancy while taking this medication, as well for at minimum three weeks following your last dose.
This medicine could impact the fertility (ability to bear kids) in men. Discuss with your doctor in case you are concerned regarding this possibility.
You shouldn’t breastfeed while using Kisqali as long as you wait at least three weeks following the last dose.
How to take Kisqali?
Use Kisqali exactly as directed by your physician. Follow the directions on your prescription label, and go through all medication guides and instructions sheets. Make sure you use the medication precisely as directed.
Kisqali is available as a 28-day treatment. You’ll take the medication for the first 21 days of every cycle, and then you will have seven days of rest. Your doctor will decide the duration of treatment with Kisqali.
Take the tablet in one swallow and make sure you don’t crush, chew or break it.
The medicine should be taken every morning, whether with or without food.
If you experience vomiting after taking the medicine be sure to wait until the next morning to get your next dose.
Don’t use an unclean or damaged pill.
It is possible that you will require frequent medical tests in order to be certain that Kisqali isn’t causing adverse consequences. The treatment you receive for cancer could be delayed depending on the results.
Keep the container in its original storage with room temperatures, and away from heat and moisture.
Usual Adult Dose for Breast Cancer:
600 mg orally, once a day for 21 consecutive days then 7 consecutive days of non-use for a total cycle of 28 days. Continue until the disease progresses or you experience unacceptable toxic effects.
Refer to the product manufacturer’s information for dosage and administration guidelines for the co-administered inhibitor of aromatase (e.g. letrozole).
When this medication is administered the recommended dosage of fulvestrant is 500 mg taken on days 1, 15 29 and 30, and then once every month thereafter. See the complete prescription information for fulvestrant.
Pre/perimenopausal women who are treated with this drug and an aromatase inhibitor, or fulvestrant are advised to treat them with a luteinizing hormone-releasing (LHRH) agonist in accordance with the current guidelines for clinical practice.
In conjunction in combination with an inhibitor of aromatase, as an initial endocrine-based treatment for the treatment of women who have hormone receptor (HR)-positive human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer.
In combination with fulvestrant to treat postmenopausal females with HR-positive metastatic or HER2-negative, advanced breast cancer, either as a first endocrine-based therapy or in the event of disease progression following endocrine therapy.
How do I deal with it if do not take the dose?
Do not miss the missed dose. The next dose should be taken at the same time, and stick to your daily schedule. Avoid taking two doses at once a day.
If I consume too much?
Get medical attention immediately or contact for help at the Poison Help line at 1-800-222-1222.
What should you be aware of to
Grapefruit could interact with ribociclib, leading to adverse consequences. Beware of using grapefruit-related products.
Beware of taking a supplement that contains St. John’s wort at the exact as you are taking Kisqali.
Side effects of Kisqali
See a doctor immediately If you experience indications warnings of an allergic response to Kisqali: (hives, difficulty breathing, swelling of your throat or face) or a severe skin reaction (fever and burning eyes, sore throat or skin pain, the skin is red or purple that blisters and peels).
Consult a doctor when you experience a severe drug reaction that affects the body in a variety of ways. Symptoms may include an itch on your skin or fever, swollen glands, muscle pains, extreme weakness, unusual bruising or yellowing of your eyes or skin.
Consult your physician immediately If you suffer from:
- Heartbeats that are fast or rapid, breathing that is fluttering as well as breathlessness and abrupt dizziness (like you’re about to pass out);
- Low white blood cells – – fever sores in the mouth and skin sores the sore throat trouble breathing, cough;
- indications of inflammation of the lung New or worsening cough breath, difficulty breathing, or feeling exhausted even when sitting down; or
- liver issues weight loss lower stomach pain, fatigue, easy bruising, bleeding or dark urine jaundice (yellowing of the eyes or skin).
The treatment you receive for cancer could be delayed or discontinued permanently when you experience some side adverse effects.
Common Kisqali side effects can be:
- Low white blood cells and infections;
- nausea, vomiting;
- diarrhea, constipation;
- headache Or
- hair loss.
This is not a comprehensive list of possible side effects, and others could happen. Consult your physician for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.
What other drugs can have an effect on Kisqali?
It is sometimes not safe to take certain medications simultaneously. Certain medications can alter the blood levels and levels of other drugs that you take, which can cause more side effects or make the medication less effective.
Ribociclib could trigger a serious heart condition. Your risk of developing heart problems is greater if you are also taking various other medications for asthma, infections or heart issues high blood pressure, mental illness, depression, malaria, cancer or HIV.
A variety of drugs interfere with the ribociclib. This includes over-the-counter and prescription medications, vitamins, and herbal supplements. The interactions of all drugs aren’t included in this list. Discuss with your physician all of your medications and any medication you begin or stop taking.
Be sure to keep all medicines away from the reach of children. Never let your medications be shared with anyone else and only use Kisqali to treat the condition prescribed.
Always consult your physician to confirm that the information provided on this site is appropriate to your specific situation.