Ixinity Dosage

Generic name: coagulation factor IX
Brand names: AlphaNine SD, Alprolix, BeneFIX, Idelvion, Ixinity
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Hemophilia B

[bleeding episode, minor]

Dose: individualize dose IV q24h x1-3 days until healing achieved; Info: estimated dose (units) = [wt (kg) x desired factor IX level (%) x 1.02] where desired factor IX level = 30-60%

[bleeding episode, moderate]

Dose: individualize dose IV q24h x2-7 days until healing achieved; Info: estimated dose (units) = [wt (kg) x desired factor IX level (%) x 1.02] where desired factor IX level = 40-60%

[bleeding episode, major]

Dose: individualize dose IV q12-24h x2-14 days until healing achieved; Info: estimated dose (units) = [wt (kg) x desired factor IX level (%) x 1.02] where desired factor IX level = 60-100%

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop, then cont. q24h x1-5 days; Info: estimated dose (units) = [wt (kg) x desired factor IX level (%) x 1.02] where desired factor IX level = 50-80% preop, then 30-80% postop

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then cont. q8-24h x14 days; Info: estimated dose (units) = [wt (kg) x desired factor IX level (%) x 1.02] where desired factor IX level = 60-80% preop, 40-60% postop days 1-3, 30-50% postop days 4-6, then 20-40% postop days 7-14

[bleeding prophylaxis, routine]

Dose: 40-70 units/kg/dose IV 2x/wk; Info: adjust dose based on clinical response

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  INJ

Hemophilia B

[bleeding episode, minor, 12 yo and older]

Dose: individualize dose IV q24h x1-3 days until healing achieved; Info: estimated dose (units) = [wt (kg) x desired factor IX level (%) x 1.02] where desired factor IX level = 30-60%

[bleeding episode, moderate, 12 yo and older]

Dose: individualize dose IV q24h x2-7 days until healing achieved; Info: estimated dose (units) = [wt (kg) x desired factor IX level (%) x 1.02] where desired factor IX level = 40-60%

[bleeding episode, major, 12 yo and older]

Dose: individualize dose IV q12-24h x2-14 days until healing achieved; Info: estimated dose (units) = [wt (kg) x desired factor IX level (%) x 1.02] where desired factor IX level = 60-100%

[bleeding prophylaxis, minor surgery, 12 yo and older]

Dose: individualize dose IV x1 preop, then cont. q24h x1-5 days; Info: estimated dose (units) = [wt (kg) x desired factor IX level (%) x 1.02] where desired factor IX level = 50-80% preop, then 30-80% postop

[bleeding prophylaxis, major surgery, 12 yo and older]

Dose: individualize dose IV x1 preop, then cont. q8-24h x14 days; Info: estimated dose (units) = [wt (kg) x desired factor IX level (%) x 1.02] where desired factor IX level = 60-80% preop, 40-60% postop days 1-3, 30-50% postop days 4-6, then 20-40% postop days 7-14

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .