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Invokana (canagliflozin)


Generic name: canagliflozin


Brand names

In the U.S.

  • Invokana

Available Dosage Forms:

  • Tablet

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Sodium Glucose Co-Transporter 2 Inhibitor

Uses for Invokana

Invokana (canagliflozin)

Invokana is used in conjunction with exercise and a balanced diet to combat Type 2 Diabetes. It also helps reduce the chance of stroke, heart attack, or even death for people suffering from type 2 diabetes, blood vessel, or heart disease. The medicine works within the kidneys to block the absorption and absorption process of glucose (blood sugar). This reduces blood sugar levels. Canagliflozin doesn’t help those suffering from insulin-dependent type one diabetes. Type 1 diabetics have to inject insulin.

Invokana can also be used to decrease the risk of acquiring end-stage kidney disease, deterioration of the function of your kidneys, as well as hospitalization due to heart failure in people suffering from type 2 diabetes or diabetes-related kidney disease, with an amount of protein in the urine.

This medication is only available on prescription from your physician.

Before making use of Invokana

When deciding whether to take a medication, the potential risks of using the medication must be considered against the benefits it can do. It is a choice you and your physician will take. In this case, to be considered, the following factors should be assessed:


Discuss with your physician If you’ve ever experienced an unusual or unrelated reaction to this medication or any other medications. Inform your health care specialist if you suffer from any other allergies, like to dyes, food preservatives, animals, or dyes. For products that are not prescription-only, you must look over the label or the ingredients on the package carefully.


No appropriate studies have been conducted to determine the connection of age to the effect of canagliflozin within the child population. Safety and efficacy haven’t been established.


The studies that have been conducted up to now haven’t revealed specific geriatric issues that could restrict the use of canagliflozin for elderly patients. However, patients who are elderly tend to suffer adverse consequences (eg dizziness, lightheadedness, dehydration, fainting) that may warrant caution when taking canagliflozin.


There aren’t enough studies on women to determine the risk to infants when taking this medication while breastfeeding. Be sure to weigh the potential benefits against the risks that could be associated with taking this medication when nursing.

Interactions between medicines

While certain medications should not be taken together, however, there are instances where two medicines can be taken together, even though there is a chance of interaction. In these situations, the doctor may decide to adjust the dosage or take other precautions if required. When you’re taking this medication it is essential to let your doctor know that you are using any one of these medications mentioned below. These interactions have been determined based on their potential importance and may not be all-inclusive.

Utilizing Invokana in conjunction in conjunction with the following medications is generally not advised, however it may be required in some instances. If two medicines are prescribed at the same time and your doctor recommends a change in the dosage or the frequency you take one or both of the drugs.

Utilizing Invokana in conjunction in conjunction with one of the following medications could result in an increased chance of experiencing certain adverse effects, however having both medicines in combination could be the best option for you. If you have prescribed both medications by your doctor, they could alter the dosage or frequency at which you take one or both drugs.

  • Acebutolol
  • Atenolol
  • Betaxolol
  • Bisoprolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Esmolol
  • Labetalol
  • Levobunolol
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Oxprenolol
  • Penbutolol
  • Pindolol
  • Practolol
  • Propranolol
  • Sotalol
  • Timolol

Interactions with alcohol, tobacco, or food

Certain medications are not recommended to be taken at or in conjunction with taking food, or eating specific kinds of food as interactions could happen. The use of tobacco or alcohol together with certain medications can create interactions. Talk to your doctor about the interactions of your medicine in conjunction with alcohol, food or tobacco.

Other medical issues

The presence of any other medical conditions could affect the usage of this medication. It is important to inform your doctor if there are any other medical conditions including:

  • History of alcohol abuse
  • Hypovolemia (low blood volume) 
  • Diabetes pancreatic-insulin deficiency, which is a risk factor for more serious adverse side adverse effects.
  • chest pain
  • Diabetic foot ulcers, 
  • Amputation of the leg (leg elimination surgery)
  • Neuropathy (nerve issue) of the leg – May increase the chance of leg Amputations.
  • Dehydration
  • Genital yeast (fungus) disease (eg balanitis, balanoposthitis, vulvovaginitis) History of or
  • The term hypotension refers to the condition of having low blood pressure (low blood pressure) or
  • Kidney disease or
  • Urinary tract infections (eg, pyelonephritis or urosepsis) or history of cautiousness. This can cause the condition to worsen.
  • Diabetic ketoacidosis (high ketones and acidity in the blood) 
  • Kidney disease, particularly severe (eg patients with end-of-life renal disease who receive dialysis) 
  • Liver disease, serious
  • Type I diabetes shouldn’t be utilized in patients suffering from these ailments.

Proper use of Invokana

Invokana should be taken only as prescribed by your physician. Don’t take more of it, don’t take it more frequently, and don’t use it for a longer duration than what your doctor has ordered.

The medicine must include a Medication, Manual. Follow these directions attentively. Consult your physician if you have any concerns.

Use this medicine prior to the first meal of the day.

Inform your physician if you are following a low salt or sodium-based diet.

Be sure to follow the meal plan your doctor has given you. This is the most crucial element of controlling your diabetes and can help your medication function properly. Do your exercise regularly and test for the presence of sugar in your urine or blood according to the directions.


The dose of Invokana can differ depending on the patient. Follow your doctor’s prescriptions or the instructions printed on your prescription. This information is only the most common dose of this medication. If your dose differs don’t alter it unless your doctor instructs you to change it.

The amount of medicine you are taking is determined by how strong the drug is. Additionally, the number of doses you will take every day, the amount of time between doses, and the duration of time that you are taking the medicine will depend on the medical condition for which you’re taking the medication.

  • For oral dosage form (tablets):
    • For type 2 diabetes as well as to reduce the risk of dying in patients suffering from type 2 diabetes, blood vessel and heart disease, and end-stage kidney disease:
      • Adults – At the beginning 100 milligrams (mg) every day to be taken prior to eating the breakfast of the day. Your doctor can alter your dosage if needed. But, the dosage is typically not greater than 300 mg every day.
      • Children–Use and dosage must be supplied by your physician.

Missed dose

If you are missing a dose of this medicine be sure to take it as fast as you can. But, if it’s close to the time for the next dose, you can skip the missed dose and then go back to your normal dose schedule. Do not take double doses.


Keep the medication in a tightly sealed container that is kept at room temperature far from moisture, heat, and sunlight. Avoid getting frozen.

Keep away from the reach of children.

Don’t keep old medicine or medications that are no longer needed.

Consult your physician to tell you how to dispose of any medication you don’t make use of.


Use with caution when making use of Invokana

It is crucial to have your doctor monitor your progress on a regular basis particularly during the first few weeks you’re taking this medicine. Tests for urine and blood may be necessary to detect undesirable negative effects.

Utilizing Invokana during the third and second part of your pregnancy may cause harm to your baby. If you suspect that you’ve been pregnant while taking this medication, inform your doctor immediately.

This medicine could increase the chance of foot, leg, or midfoot amputations (leg elimination surgery). Consult your physician right immediately if you experience tenderness, pain, ulcers or sores, or infections of your foot or leg.

Lightheadedness, dizziness, or fainting can be a result of the medication. It is more frequent in the case of kidney disease, blood pressure that is low, or is taking diuretics (water pills). Drinking plenty of fluids throughout the day could aid. Drink plenty of water when you exercising or during the heat. Consult your physician in case you experience extreme nausea, vomiting, or diarrhea that won’t end. This could cause you to lose too much fluid.

Ketoacidosis (high ketones and acid levels in the blood) can occur when taking this medication. This is a life-threatening condition and requires medical attention immediately. Your doctor could prescribe insulin, fluid, or carbohydrate replacement in order to manage this condition. Inform your doctor immediately when you experience nausea or vomiting difficulty breathing, increased thirst, or the need to urinate.

Consult your physician right now if you experience bloody urine, a decrease or decrease in the amount or often you are urinating, an increase of blood pressure a rise in thirst, a decrease in appetite, back or side pains nausea or swelling of the face, fingers and lower legs. difficulty breathing, unusual fatigue or vomiting, weakness, or weight growth. These are signs of a more serious kidney condition.

Invokana can cause vaginal yeast infections in women as well as yeast infections of the penis of males. This is more prevalent for those with a previous history of genital yeast infection or those who aren’t circumcised. Women can experience Vaginal discharge or itching or an odor. Men might have swelling, redness, itching, or pain in the penis or a discharge that has an unpleasant odor that comes due to the penis. Consult your physician promptly if you experience any of these signs.

The risk of serious allergic reactions is high when you take this medication. Talk to your doctor immediately if you notice an allergic reaction to your skin, such as itching or hives or redness on the skin, breathing problems, or a large swelling, similar to hives, on the eyes, face, lips, and throat, tongue feet, hands, legs or the genitals.

Invokana could increase the chance of sustaining bone fractures. Talk to your doctor for tips on how to strengthen your bones to avoid fractures.

Invokana can trigger hyperglycemia (low levels of blood sugar). This can be more prevalent when taking this medication alongside other diabetes drugs (eg insulin, glipizide, or Glyburide). The low blood sugar level must be addressed before it causes the patient to faint (unconsciousness). Different people experience different symptoms of lower blood sugar. It is essential to know what symptoms you typically suffer from so that you can address it promptly. Discuss with your doctor the best method to manage low blood sugar levels.

Hyperglycemia (high blood sugar) can occur when you don’t take enough or miss the dosage of your diabetes medication in excess, eat too much or don’t adhere to your diet regimen and you are suffering from an infection or fever, or don’t exercise as often as you normally.

The signs that indicate high blood sugar may include blurred vision, drowsiness dry mouth, dry and flushed skin, a fruity breath odor, a greater frequency and frequency of urination, ketones present in the urine, a loss of appetite nausea or vomiting fast and intense breathing fatigue or unusual thirst. If signs of high blood sugar develop, be sure to take a look at your blood sugar levels and contact your physician to get the proper treatment.

Invokana can increase your chances of developing urinary tract infections such as Urosepsis or pyelonephritis. Talk to your doctor now if you are experiencing urinary discomfort, bloody or cloudy urine, burning, painful or painful urination, or side or lower back discomfort.

Invokana could trigger an uncommon but serious bacteria-related infection known as necrotizing fasciitis in the perineum or Fournier’s Gangrene, which can result in damage to the tissue beneath the skin, in the region between and between the genitals and anus (perineum). Fournier’s gangrene can result in hospitalization, several operations, or even death. Consult your physician right immediately if you experience an unusually tired or feverish feeling, weakness, and redness. or swelling in the region between your genitals and your anus.

Invokana can cause severe allergic reactions, such as angioedema and anaphylaxis. These reactions could cause serious harm and need urgent medical treatment. Contact your physician immediately when you notice an itchy or rashy skin or blistering, peeling or loosening of your skin, chills or fever difficulty breathing or swallowing, or experiencing swelling in your face, hands mouth, or throat while using this medication.

It is important that your dentist or doctor who sees you know that you’re taking this medication. The medicine could alter the outcomes of certain medical tests (eg the glucose levels in urine could not be reliable). Additionally, you might need to be able to discontinue this medication at least 3 days prior to the time of your surgery.

Do not take any other medications without discussing them with your physician. This includes prescription and prescription (over-the-counter OTC) medications as well as herbal or vitamin supplements.

Invokana side effects

In addition to the beneficial effects, some medicines may produce unwanted side negative effects. While not all negative side effects are likely to be present, if they do occur, they might require medical attention.

Consult your physician immediately If any of these adverse effects happen:

More popular

  • Bladder pain
  • Bloating
  • Bloody or cloudy urine
  • reduced frequency or quantity of less urine
  • painful pain, burning, or difficult urinary tract
  • The discharge is accompanied by a strong odor from the penis
  • Urinary urges that are frequent
  • an increase in thirst
  • an increased desire to urinate at night the night
  • indigestion
  • vaginal itching or the outside of the Genitals
  • Loss of appetite
  • Side or lower back discomfort
  • nausea
  • pain during sexual intercourse
  • irritation in the skin in the penis
  • issues with urination or an increased amount of urine
  • Itching, redness, and swelling or redness of penis
  • swelling of the fingers, face, or lower legs
  • Vaginal discharge that is white and thick with no or mild scent
  • Trouble breathing
  • unusual weakness or fatigue
  • vomiting
  • The night before, you wake up to go to the bathroom.
  • weight gain

Less popular

  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • confusion
  • cool, pale skin
  • Depression
  • dizziness
  • dry mouth
  • Heartbeats that are irregular or fast
  • Redness, flushing, and flushing of the skin
  • headache
  • Itching skin or rash
  • an increase in appetite
  • Itching skin
  • massive, hive-like swelling that covers the eyes, face, and lips. It can also be seen on the tongue and throat, hands feet, legs, or the genitals
  • nightmares
  • Redness on the skin
  • seizures
  • Shaking
  • Slurred speech
  • Extremely warm skin

The exact cause is not known.

  • dizziness, faintness, or lightheadedness after rising abruptly from a sitting or lying in a seated
  • febrile
  • Dry skin, flushed
  • UTIs that are painful or frequent
  • Fruity breath smell
  • more frequent the frequency of urination
  • loss of consciousness
  • Tingling or numbness in the feet, hands, or the lips
  • Redness, tenderness, pain, or swelling in the region between the anus as well as the genitals
  • stomach pain
  • sweating
  • Unexplained weight loss that is not explained
  • weight or weakness of the legs
  • Skin or eyes with yellow eyes

Certain side effects can be experienced which usually don’t require medical treatment. These side effects can disappear after treatment, as the body adapts. Additionally, your doctor might be able to inform you on how to prevent or lessen the effects of these adverse effects. Talk to your physician for any of these symptoms persist or become uncomfortable or if there are any concerns about these:

Less well-known

  • The trouble with bowel movements
  • falls
  • weakness or lack of strength or
  • swelling or pain in the legs or arms with no injury


  • The skin’s sensitivity increases to sun
  • the skin. It may also be discoloration or redness. the skin
  • severe sunburn

Other adverse side effects that are not listed can also occur in certain patients. If you observe any other side effects, you should consult with your physician.

Contact your doctor to seek medical advice on possible side effects. You can report adverse reactions at the FDA at 1-800-FDA-1088.

More details

Always consult your doctor to make sure the information presented on this site is appropriate to your specific situation.


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