Idelvion Dosage

Generic name: coagulation factor IX
Brand names: AlphaNine SD, Alprolix, BeneFIX, Idelvion, Ixinity,
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Hemophilia B

[bleeding episode, minor-moderate]

Dose: individualize dose IV x1; may repeat dose q48-72h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 0.77] where desired factor IX level 30-60%

[bleeding episode, major]

Dose: individualize dose IV q48-72h x7-14 days or until hemostasis, then give qwk; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 0.77] where desired factor IX level 60-100%

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop; may repeat dose q48-72h until healing achieved; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 0.77] where desired factor IX level 50-80%

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then cont. q48-72h x7-14 days or until healing achieved, then give 1-2x/wk; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 0.77] where desired factor IX level 60-100%

[routine bleeding prophylaxis]

Dose: 25-40 units/kg/dose IV qwk; Info: in well controlled pts, may use 50-75 units/kg/dose IV q2wk

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  INJ

Hemophilia B

[bleeding episode, minor-moderate, <12 yo]

Dose: individualize dose IV x1; may repeat dose q48-72h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 30-60%

[bleeding episode, minor-moderate, 12 yo and older]

Dose: individualize dose IV x1; may repeat dose q48-72h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 0.77] where desired factor IX level 30-60%

[bleeding episode, major, <12 yo]

Dose: individualize dose IV q48-72h x7-14 days or until hemostasis, then give qwk; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 60-100%

[bleeding episode, major, 12 yo and older]

Dose: individualize dose IV q48-72h x7-14 days or until hemostasis, then give qwk; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 0.77] where desired factor IX level 60-100%

[bleeding prophylaxis, minor surgery, <12 yo]

Dose: individualize dose IV x1 preop; may repeat dose q48-72h until healing achieved; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 50-80%

[bleeding prophylaxis, minor surgery, 12 yo and older]

Dose: individualize dose IV x1 preop; may repeat dose q48-72h until healing achieved; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 0.77] where desired factor IX level 50-80%

[bleeding prophylaxis, major surgery, <12 yo]

Dose: individualize dose IV x1 preop, then cont. q48-72h x7-14 days or until healing achieved, then give 1-2x/wk; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 1] where desired factor IX level 60-100%

[bleeding prophylaxis, major surgery, 12 yo and older]

Dose: individualize dose IV x1 preop, then cont. q48-72h x7-14 days or until healing achieved, then give 1-2x/wk; Info: estimated dose (units) is [wt (kg) x desired factor IX level (%) x 0.77] where desired factor IX level 60-100%

[routine bleeding prophylaxis, <12 yo]

Dose: 40-55 units/kg/dose IV qwk

[routine bleeding prophylaxis, 12 yo and older]

Dose: 25-40 units/kg/dose IV qwk; Info: in well controlled pts, may use 50-75 units/kg/dose IV q2wk

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .