Camzyos

Generic Name: mavacamten
Dosage Form: capsules

Medically reviewed by  A Ras. MD Last updated on May 1,  2022.

What is Camzyos?

Camzyos is a prescription medicine used to treat adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM).

Camzyos may improve your symptoms and your ability to be active.

Description

Camzyos capsules for oral use contain mavacamten, a cardiac myosin inhibitor.
The chemical name of mavacamten is 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-
2,4(1H,3H)-pyrimidinedione. The molecular formula is C15H19N3O2, and the molecular weight is
273.33 g/mol.
The structural formula of mavacamten is:

Camzyos
Mavacamten is a white to off-white powder that is practically insoluble in water and aqueous
buffers at pH 2-10, sparingly soluble in methanol and ethanol, and freely soluble in DMSO and
NMP.
This is supplied as immediate release Size 2 hard gelatin capsules, containing 2.5, 5, 10,
or 15 mg of mavacamten per capsule as active ingredient and the following inactive ingredients:
croscarmellose sodium, hypromellose, magnesium stearate (non-bovine), mannitol, and silicon
dioxide. The capsule shell contains black edible ink, black iron oxide, gelatin, red iron oxide,
titanium dioxide, and yellow iron oxide.

Important information to know

Camzyos may cause serious side effects, including:

See Camzyos side effects for information about side effects.

Before you take Camzyos

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

What ar the other drugs that will affect Camzyos?

Before and during treatment, tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking Camzyos with certain medicines or grapefruit juice may cause heart failure. Do not stop or change the dose of a medicine or start a new medicine without telling your healthcare provider.

Especially tell your healthcare provider if you:

How should I take Camzyos?

Dosing information

Usual Adult Dosage for Hypertrophic Cardiomyopathy

– recommended starting dose is 5 mg once daily without regard to food; allowable subsequent doses with titration are 2.5, 5, 10, or 15 mg once daily.  Patient’s clinical status and LVEF should be assessed prior to and regularly during treatment and the dose adjusted accordingly.

– Use: treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms.

Camzyos side effects

This medication may cause serious side effects, including:

The most common side effects include: dizziness and fainting (syncope).

These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Bristol-Myers Squibb at 1-800-721-5072.

How should I store Camzyos?

Store it at room temperature between 68°F to 77°F (20°C to 25°C).

Keep medicines out of the reach of children and pets.

General information about the safe and effective use of Camzyos.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms you have. It may harm them. You can ask your healthcare provider or pharmacist for information that is written for health professionals.

What are the ingredients in Camzyos?

Active ingredient: mavacamten
Inactive ingredients: croscarmellose sodium, hypromellose, magnesium stearate (non-bovine), mannitol, and silicon dioxide. The capsule contains black iron oxide, gelatin, red iron oxide, titanium dioxide, and yellow iron oxide.

 

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