ANSAID SIDE EFFECTS
- Generic Name: flurbiprofen
- Brand Name: Ansaid
- Drug Class: NSAIDs
Last updated on MDtodate: 10/6/2022
SIDE EFFECTS
TABLE 1: Reported adverse events in patients receiving ANSAID (flurbiprofen) or other nonsteroidal anti-inflammatory drugs
| Reported in patients treated with ANSAID | Reported in patients treated with other products but not ANSAID | ||
| Incidence of 1% or greater † | Incidence < 1% – Causal Relationship Probable ‡ | Incidence < 1% – Causal Relationship Unknown ‡ | |
| BODY AS A WHOLE edema |
anaphylactic reaction chills fever |
< 1%: death infection sepsis |
|
| CARDIOVASCULAR SYSTEM | congestive heart failure hypertension vascular diseases vasodilation |
angina pectoris arrhythmias myocardial infarction |
< 1%: hypotension palpitations syncope tachycardia vasculitis |
| DIGESTIVE SYSTEM abdominal pain constipation diarrhea dyspepsia/heartburn elevated liver enzymes flatulence GI bleeding nausea vomiting |
bloody diarrhea esophageal disease gastric/peptic ulcer disease gastritis jaundice (cholestatic and noncholestatic) hematemesis hepatitis stomatitis/glossitis |
appetite changes cholecystitis colitis dry mouth exacerbation of inflammatory bowel disease periodontal abscess small intestine inflammation with loss of blood and protein |
> 1%: GI perforation GI ulcers (gastric/duodenal) < 1%: eructation liver failure pancreatitis |
| HEMIC AND LYMPHATIC SYSTEM | aplastic anemia (including agranulocytosis or pancytopenia) decrease in hemoglobin and hematocrit ecchymosis/purpura eosinophilia hemolytic anemia iron deficiency anemia leukopenia thrombocytopenia |
lymphadenopathy | > 1%: anemia increased bleeding time < 1%: melena rectal bleeding |
| METABOLIC AND NUTRITIONAL SYSTEM body weight changes |
hyperuricemia | hyperkalemia | < 1%: hyperglycemia |
| NERVOUS SYSTEM headache nervousness and other manifestations of entral nervous system (CNS) stimulation (eg, anxiety, insomnia, increased reflexes, tremor) symptoms associated with CNS inhibition (eg, amnesia, asthenia, depression, malaise, somnolence) |
ataxia cerebrovascular ischemia confusion paresthesia twitching |
convulsion cerebrovascular accident emotional lability hypertonia meningitis myasthenia subarachnoid hemorrhage |
< 1%: coma dream abnormalities drowsiness hallucinations |
| RESPIRATORY SYSTEM rhinitis |
asthma epistaxis |
bronchitis dyspnea hyperventilation laryngitis pulmonary embolism pulmonary infarct |
< 1%: pneumonia respiratory depression |
| SKIN AND APPENDAGES rash |
angioedema eczema exfoliative dermatitis photosensitivity pruritus toxic epidermal necrolysis urticaria |
alopecia dry skin herpes simplex/zoster nail disorder sweating |
< 1%: erythema multiforme Stevens Johnson syndrome |
| SPECIAL SENSES changes in vision dizziness/vertigo tinnitus |
conjunctivitis parosmia |
changes in taste corneal opacity ear disease glaucoma retinal hemorrhage retrobulbar neuritis transient hearing loss |
> 1%: pruritus < 1%: hearing impairment |
| UROGENITAL SYSTEM signs and symptoms suggesting urinary tract infection |
hematuria interstitial nephritis renal failure |
menstrual disturbances prostate disease vaginal and uterine hemorrhage vulvovaginitis |
> 1%: abnormal renal function < 1%: dysuria oliguria polyuria proteinuria |
| † from clinical trials ‡ from clinical trials, post-marketing surveillance, or literature |
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SRC: NLM .