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Name of the generic: amitriptyline
Class of drugs: Tricyclic antidepressants

Oral route(Tablet)


Antidepressants increased the likelihood of suicidal behavior and thoughts in adolescents, children, and young adults in short-term studies of major depression disorder (MDD) as well as other mental disorders. Studies conducted in the short-term did not reveal an increase in the likelihood of suicide when using antidepressants in comparison to placebo in adults older than 24 years old. There were fewer risks of suicide with antidepressants as compared to placebo among adults 65 and over. The risk has to be balanced against the clinical necessity. Be sure to monitor patients for signs of depressive symptoms, suicidal behavior, or any unusual behavior changes. Families and caregivers need to be informed of the need for continuous monitoring and contact with the doctor. This medication is not approved for use by children.

Brand names


  • Elavil
  • Vanatrip

Available Dosage Forms:

  • Tablet

Therapeutic Class: Antidepressant

Pharmacologic Class: Antidepressant, Tricyclic

Amitriptyline is a drug that can be used

Amitriptyline is a medication used to treat depression symptoms. It affects the central nervous system (CNS) to raise levels of certain chemical substances in the brain. Amitriptyline is a tricyclic antidepressant (TCA).

Amitriptyline can only be purchased on prescription from your physician.

Before making use of amitriptyline

When you decide to take a medication, the potential risks of using the drug should be evaluated against the positive effects it could bring. It is a choice you as well as your doctor make. When taking amitriptyline, these must be taken into consideration:


Discuss with your physician If you’ve ever experienced an unusual reaction or allergy to amitriptyline, or any other medications. Be sure to inform your health doctor if you suffer from other allergies, like dyes, food, or preservatives. You may also be allergic to animals. For products that are not prescription-only, you must look over the label or ingredient list carefully.


Studies that are appropriate have not been conducted to determine the relationship of age and adverse effects of amitriptyline children younger than 12 years old age. Safety and efficacy haven’t been established.


The studies that have been conducted so far have not revealed specific geriatric issues that could restrict the use of amitriptyline for the older. However, older patients tend to develop liver disorders that are a result of age, and this might require adjusting the dosage of patients receiving the medication amitriptyline.


There aren’t enough research studies on women to determine the risks to babies when taking this medication while breastfeeding. Consider the benefits and the risk of taking this medication when nursing.

Interactions between medicines

While certain medications should not be combined in any way, however, there are instances where two different medications can be taken together, even if interactions could occur. In these situations, your doctor might decide to alter the dosage or take other precautions if needed. If you’re taking amitriptyline, it’s particularly important to let your doctor know that they are using any one of these medications mentioned below. The following interactions were chosen based on their potential impact and are not all-inclusive.

Amitriptyline use in conjunction with any of the following medications is not advised. Your physician may decide to not treat you with this drug or modify one of the other medications you are taking.

  • Bepridil
  • Bromopride
  • Cisapride
  • Clorgyline
  • Dronedarone
  • Furazolidone
  • Grepafloxacin
  • Iproniazid
  • Isocarboxazid
  • Levomethadyl
  • Linezolid
  • Mesoridazine
  • Methylene Blue
  • Metoclopramide
  • Moclobemide
  • Nialamide
  • Pargyline
  • Phenelzine
  • Pimozide
  • Piperaquine
  • Procarbazine
  • Ranolazine
  • Safinamide
  • Saquinavir
  • Selegiline
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Toloxatone
  • Tranylcypromine
  • Ziprasidone

The use of amitriptyline conjunction in conjunction with any of these drugs is not usually advised, however it may be necessary in certain situations. If the two medicines are prescribed in conjunction the doctor could alter the dose or the frequency at which you take one or both of the medications.

  • Acecainide
  • Aceclofenac
  • Acemetacin
  • Albuterol
  • Alfentanil
  • Alfuzosin
  • Almotriptan
  • Amiodarone
  • Amisulpride
  • Amoxapine
  • Amphetamine
  • Amtolmetin Guacil
  • Anagrelide
  • Apomorphine
  • Aprindine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Aspirin
  • Astemizole
  • Atazanavir
  • Azimilide
  • Azithromycin
  • Benzhydrocodone
  • Benzphetamine
  • Bretylium
  • Bromfenac
  • Brompheniramine
  • Bufexamac
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Buspirone
  • Butorphanol
  • Celecoxib
  • Ceritinib
  • Chloral Hydrate
  • Chloroquine
  • Chlorpheniramine
  • Chlorpromazine
  • Choline Salicylate
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clomipramine
  • Clonidine
  • Clonixin
  • Clozapine
  • Cocaine
  • Codeine
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Darunavir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Desmopressin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexibuprofen
  • Dexketoprofen
  • Dextroamphetamine
  • Dextromethorphan
  • Diclofenac
  • Diflunisal
  • Dihydrocodeine
  • Dipyrone
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Droperidol
  • Droxicam
  • Efavirenz
  • Eletriptan
  • Encorafenib
  • Enflurane
  • Entrectinib
  • Epinephrine
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenfluramine
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Fexinidazole
  • Fingolimod
  • Flecainide
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Foscarnet
  • Fostemsavir
  • Frovatriptan
  • Gatifloxacin
  • Gemifloxacin
  • Glasdegib
  • Glucagon
  • Glycopyrrolate
  • Glycopyrronium Tosylate
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydrocodone
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxytryptophan
  • Hydroxyzine
  • Ibuprofen
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Indomethacin
  • Inotuzumab Ozogamicin
  • Iobenguane I 123
  • Iobenguane I 131
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lacosamide
  • Lapatinib
  • Lasmiditan
  • Lefamulin
  • Lenvatinib
  • Levalbuterol
  • Levofloxacin
  • Levomilnacipran
  • Levorphanol
  • Lidoflazine
  • Lisdexamfetamine
  • Lithium
  • Lofexidine
  • Lopinavir
  • Lorcainide
  • Lorcaserin
  • Lornoxicam
  • Loxapine
  • Loxoprofen
  • Lumefantrine
  • Lumiracoxib
  • Macimorelin
  • Meclofenamate
  • Mefenamic Acid
  • Mefloquine
  • Meloxicam
  • Meperidine
  • Metaxalone
  • Methacholine
  • Methadone
  • Methamphetamine
  • Metronidazole
  • Milnacipran
  • Mirtazapine
  • Mobocertinib
  • Moricizine
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nabumetone
  • Nafarelin
  • Nalbuphine
  • Naproxen
  • Naratriptan
  • Nefazodone
  • Nefopam
  • Nepafenac
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Norepinephrine
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxaprozin
  • Oxycodone
  • Oxymetazoline
  • Oxymorphone
  • Oxyphenbutazone
  • Ozanimod
  • Paliperidone
  • Palonosetron
  • Panobinostat
  • Parecoxib
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pentamidine
  • Pentazocine
  • Phenylbutazone
  • Piketoprofen
  • Pimavanserin
  • Piroxicam
  • Pitolisant
  • Pixantrone
  • Ponesimod
  • Posaconazole
  • Pranoprofen
  • Procainamide
  • Prochlorperazine
  • Proglumetacin
  • Promethazine
  • Propafenone
  • Propoxyphene
  • Propyphenazone
  • Proquazone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Rasagiline
  • Remifentanil
  • Revefenacin
  • Ribociclib
  • Risperidone
  • Rizatriptan
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Scopolamine
  • Secretin Human
  • Selpercatinib
  • Sematilide
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Siponimod
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Sodium Salicylate
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • Sufentanil
  • Sulfamethoxazole
  • Sulindac
  • Sulpiride
  • Sultopride
  • Sumatriptan
  • Sunitinib
  • Tacrolimus
  • Tapentadol
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tenoxicam
  • Tetrabenazine
  • Tiaprofenic Acid
  • Tiotropium
  • Tolfenamic Acid
  • Tolmetin
  • Toremifene
  • Tramadol
  • Trazodone
  • Triclabendazole
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Tryptophan
  • Valdecoxib
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vilazodone
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Vortioxetine
  • Zolmitriptan
  • Zotepine
  • Zuclopenthixol

The use of amitriptyline along together with the following drugs could result in an increased risk of some adverse effects, however having both medicines in combination could be the most effective treatment for you. If both medications are prescribed in conjunction the doctor could alter the dosage or the frequency you take one or both drugs.

  • Acenocoumarol
  • Arbutamine
  • Atomoxetine
  • Bethanidine
  • Carbamazepine
  • Cimetidine
  • Desogestrel
  • Diazepam
  • Dicumarol
  • Dienogest
  • Drospirenone
  • Ethinyl Estradiol
  • Ethynodiol
  • Fluvoxamine
  • Fosphenytoin
  • Galantamine
  • Gestodene
  • Guanethidine
  • Levonorgestrel
  • Mestranol
  • Nomegestrol
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Phenprocoumon
  • Phenytoin
  • Rifapentine
  • Ritonavir
  • S-Adenosylmethionine
  • St John’s Wort
  • Warfarin

Interactions with food, tobacco, and alcohol

Certain medications shouldn’t be taken during or near the time of having food items or eating particular kinds of food, as interactions can happen. Smoking or drinking alcohol in conjunction with certain medicines can create interactions. The following interactions have been chosen because of their potential importance and are not intended to be comprehensive.

Utilizing amitriptyline in conjunction together with the following is not recommended, however, it could be necessary in certain instances. If they are used in conjunction the doctor may alter the dosage or frequency you take amitriptyline. They may also provide specific guidelines regarding the consumption of food, tobacco, or alcohol.

  • Tobacco

Utilizing amitriptyline in conjunction in conjunction with any of the following could result in an increased risk of some adverse effects, but they may be inevitable in certain instances. If you take them together the doctor may alter the dosage or frequency you take amitriptyline. They may also provide you with specific instructions regarding the consumption of food, alcohol, or tobacco.

  • Ethanol

Other medical conditions

The presence of any other medical conditions can affect the usage of amitriptyline. Be sure to inform your physician if you suffer from any other medical conditions particularly:

  • Bipolar disorder (mood disorder with periodic depression and mania) or the risk of
  • Recent heart attack–Shouldn’t be utilized in patients with the following conditions.
  • Diabetes 
  • Glaucoma 
  • Heart disease 
  • Thyroid hyperactivity 
  • Schizophrenia 
  • Seizures
  • Urinary retention (trouble with urination) and history of cautiousness. It can make the condition worse.
  • Use with care. The effect may be heightened due to the slower elimination of the medication in the human body.

Properly using Amitriptyline

Amitriptyline should be taken only according to your doctor’s instructions to improve your health as much as is possible. Do not take more than it, and don’t do more frequently, and don’t take it for any longer duration than the doctor has ordered.

Amitriptyline includes a medication manual. Take note of the information in the document attentively. Consult your physician if you have any queries¹.


The dosage of amitriptyline is likely to differ depending on the patient. Follow the doctor’s instructions or the instructions in the prescription. This information is only the doses that are typical of Amitriptyline. If you have a different dose you should not alter it until your doctor instructs you to change it.

The quantity of medicine you consume is contingent on your strength drug. In addition, the number of doses that you are taking each day, the amount of time between doses, as well as the amount of time you use the medication depend on the medical condition for which you’re taking the medication.

  • For oral dosage forms (tablets):
    • For depression:
      • Adults – At first 75 milligrams (mg) per day, taken in doses divided of 50-100 mg at nighttime. Your physician may alter the dosage if required. But, the dosage is generally not greater than 150 mg daily except if you are in a hospital. Certain patients in hospitals may require greater dosages.
      • Adults aged between 10 and 15 – 10 milligrams (mg) three times per day. 20 mg before bedtime. Your physician may alter the dosage as necessary.
      • Children who are younger than 12 years of age – The dosage and dosage should be determined by your physician.

Missed dose

If you have missed an amitriptyline dose, make sure to take it as soon as you can. But, if it’s close to the time for the next dose, you can skip the missed dose and then go back to your usual dose schedule. Don’t double doses.


Place the medicine in a tightly sealed bottle at room temperatures, and away from moisture, heat, and bright light. Be sure to keep the medicine from the medicine from freezing.

Keep your items out of reach of children.

Don’t keep old medicine or medicines that are no longer required.

Consult your physician to tell you how to dispose of any medication you don’t make use of.

Amitriptyline is a drug that can cause serious harm.

It is vital to have your doctor monitor your progress on a regular basis to ensure that you are able to adjust in dosage, and also to look for any undesirable negative effects.

Amitriptyline could cause some individuals to feel agitated, angry or exhibit other unusual behavior. It can also trigger individuals to experience suicidal thoughts and depressive tendencies, or be more depression. Should you, or your caretaker are aware of any of these consequences, consult your physician immediately.

Avoid taking amitriptyline after you’ve taken any monoamine oxide (MAO) inhibitor (isocarboxazid [Marplan(r)] or the phenelzine [Nardil(r) selegiline [Eldepryl(r) and tranylcypromine [Parnate(r)[Parnate(r)]) within the last 2 weeks. Do not begin taking a MAO inhibitor before 5 days after stopping the amitriptyline. In the event that you try, you might be prone to confusion, agitation anxiety, stomach or intestinal symptoms, sudden elevation of body temperature, extreme hypertension, and extreme convulsions.

Do not take any other medications until they’ve been discussed with your physician. When you take amitriptyline in combination with Cisapride (Propulsid(r)) can increase the risk of severe adverse negative effects.

Do not stop abruptly taking amitriptyline before consulting with your physician. Your doctor might advise you to gradually decrease the amount of medication you’re taking before stopping completely. This could help to prevent an eventual aggravation of your condition and decrease the risk of experiencing withdrawal-related symptoms like nausea, headache, or general feelings of illness or discomfort.

Amitriptyline can enhance alcohol’s effects as well as other CNS depressants (medicines that slow down nerves, perhaps creating the feeling of drowsiness). Examples of CNS depressants include antihistamines, remedies that treat allergies, allergies, or colds. They also include tranquilizers, sedatives or sleeping pills prescribed pain medication as well as narcotics medication for seizures; muscles relaxants or anesthetics which includes some dental anesthetics. The effect can be present for several weeks after you take amitriptyline off the market. Consult your physician prior to using any of the medications listed above while taking amitriptyline.

Prior to any type of procedure, tell the doctor who is in charge that you’re using amitriptyline. Combining amitriptyline with other medications utilized during surgery can increase the chance of having side consequences.

Amitriptyline may affect blood sugar levels. If you notice any changes in your urine or blood test for sugar or are unsure, you should consult with your doctor.

Amitriptyline could cause some people to feel drowsy. Make sure you are aware of what your reaction to amitriptyline is prior to driving, using drugs, or do anything else that may be hazardous if you’re sleepy or unaware.

Amitriptyline side effects

Alongside its necessary effects, medicines can produce unwanted side adverse effects. While not all of these negative side effects are likely to occur, if they occur, they could require medical attention.

Talk to your doctor immediately in the event that any of these adverse effects happen:

The exact cause is not known.

  • Stomach or abdominal pain
  • Affliction
  • Black, tarry stool
  • bleeding gums
  • Blood in urine or stool
  • blurred vision
  • burning and itching the sensation of being numb, or prickly, “pins and needles” or tingling sensations
  • change in consciousness
  • variations in the patterns and rhythms of speech
  • chest pain or discomfort in the chest.
  • chills
  • cold sweats
  • Coma
  • confusion
  • Uncertainty about identity, location, and the passage of time
  • continuous buzzing, ringing or some other unanswered noises in the ears
  • convulsions
  • cool, pale skin
  • cough or hoarseness or cough
  • Dark urine that is dark
  • less frequent the frequency of
  • diminution in the volume of urine
  • lower output of urine
  • difficulty breathing
  • difficulties in passing urine (dribbling)
  • problems with speaking
  • disturbances in accommodation
  • disturbed concentration
  • faintness, dizziness or lightheadedness when rising from a sitting or lying posture suddenly
  • double vision
  • Drooling
  • dry mouth
  • Excited
  • fainting
  • False beliefs that cannot be altered by the facts
  • heartbeats that are slow, fast or irregular heartbeat
  • anxiety or anxiety
  • Chills or fever
  • Dry, flushed skin
  • Fruity-like breath odor
  • general feeling of fatigue or weakness
  • headache
  • hearing loss
  • high fever
  • Low or high blood pressure
  • hostility
  • inability to move legs, arms or facial muscles
  • inability to speak
  • an increase in appetite
  • the increased need to urinate
  • Increased pressure in the ocular area
  • Increased sweating
  • an increase in thirst
  • more frequent urine production
  • irritability
  • Lack of coordination
  • Lethargy
  • Light-colored stools
  • lipsmacking or puckering
  • Appetit loss
  • Balance control issues
  • Loss of bladder control
  • loss of consciousness
  • Lower back or side or side
  • Anxiety or depression in the form of mental illness
  • muscle spasms or jerking of the entire extremity
  • Muscle tightness
  • muscle trembling, jerking, or stiffness
  • Muscle that is twitching
  • nausea and vomiting
  • nightmares or vivid dreams that are unusually vivid
  • Reflexes that are overactive
  • uncomfortable or painful urination
  • having more frequent urination
  • Red spots that are precise on the skin
  • poor coordination
  • A pounding sound in the ears
  • the churning of cheeks
  • fast or worm-like movements of the tongue
  • rapid weight gain
  • insanity
  • being able to hear, see or sense things that aren’t present
  • seizures
  • Muscle stiffness that is severe
  • Shaking and unsteady walk
  • Shivering
  • breathlessness
  • Walking in a shuffling fashion
  • insomnia
  • Slow speech
  • Speech slurred
  • sore throat
  • sores, ulcers, and white marks on the lips or inside the mouth
  • stiffness of the limbs
  • stupor
  • abrupt loss of consciousness
  • sweating
  • swelling of the face, ankles or hands
  • Acne swelling or puffiness
  • swollen glands
  • engaging in conversation or acting out with enthusiasm that you can’t be in control of
  • difficulty in speaking
  • difficulty sleep
  • Troubled breathing
  • The body’s twisting movements cause tension or discomfort in the muscles, jaw, or back
  • Inability to fall asleep
  • Uncontrolled chewing movement
  • Uncontrolled movements, particularly of neck, face, arms, and back
  • Unexplained weight loss that is not explained
  • Bad breath unpleasant breath
  • unstable, trembling, or other motor control, coordination, or muscle strength
  • unusual bleeding or unusual bleeding or
  • unusual fatigue or weakness
  • very pale skin
  • Upper right abdominal discomfort in the upper right abdominal
  • Vomiting of blood
  • weak hands, arms, or legs
  • weight loss or gain
  • Yellow eyes and skin

Seek emergency assistance immediately in the event that any of the following signs of overdose develop:

Symptoms of Overdose

  • Clumsiness
  • Drool
  • lower body temperature
  • Muscle aches
  • Muscle weakness
  • insomnia
  • tiredness
  • A weak, sluggish pulse

Certain side effects can be experienced but they usually do not require medical treatment. These side effects can be eliminated when your body adjusts the medication. Additionally, your health professional could be able to inform you of ways to avoid or minimize certain adverse effects. Consult your doctor for any of these adverse effects that persist or are troubling or if there are any concerns about these:

The exact cause is not known.

  • Dilated, larger, or expanded pupils (black part of the eye)
  • black tongue
  • Bloating
  • breast enlargement among females
  • constipation
  • lower interest in sexual interactions
  • diarrhea
  • hair loss, hair loss, and thinning
  • Hives or welts
  • inability to maintain or have an inability to have or keep an
  • an increase in sexual capability and drive or increased sexual ability, desire, or
  • an increase in interest in sexual encounters
  • Increased sensitivity of eyes to the light
  • lack of sexual capability or drive, desire or loss of sexual ability, desire, drive or
  • Loss of sense of smell
  • the skin. It may be red or a different color. skin
  • severe sunburn
  • the skin the rash
  • the swelling of the testicles
  • swelling of the breasts, or breast tenderness in males
  • growth of parotid glands
  • inflammation or swelling of the mouth
  • Extra or unexpected lactation from the breasts

Other side effects that aren’t mentioned may occur in certain patients. If you observe any other side effects, you should consult with your physician.


Additional details

Always consult your doctor to confirm that the information provided on this page is applicable to your particular situation.

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