Amitriptyline

Name of the generic: amitriptyline
Class of drugs: Tricyclic antidepressants

Oral route(Tablet)

Antidepressants increased the likelihood of suicidal behavior and thoughts in adolescents, children, and young adults in short-term studies of major depression disorder (MDD) as well as other mental disorders. Studies conducted in the short-term did not reveal an increase in the likelihood of suicide when using antidepressants in comparison to placebo in adults older than 24 years old. There were fewer risks of suicide with antidepressants as compared to placebo among adults 65 and over. The risk has to be balanced against the clinical necessity. Be sure to monitor patients for signs of depressive symptoms, suicidal behavior, or any unusual behavior changes. Families and caregivers need to be informed of the need for continuous monitoring and contact with the doctor. This medication is not approved for use by children.

Brand names

Elavil
Vanatrip

Available Dosage Forms:

Tablet

Therapeutic Class: Antidepressant

Pharmacologic Class: Antidepressant, Tricyclic

Amitriptyline is a drug that can be used

Amitriptyline is a medication used to treat depression symptoms. It affects the central nervous system (CNS) to raise levels of certain chemical substances in the brain. Amitriptyline is a tricyclic antidepressant (TCA).

Amitriptyline can only be purchased on prescription from your physician.

Before making use of amitriptyline

When you decide to take a medication, the potential risks of using the drug should be evaluated against the positive effects it could bring. It is a choice you as well as your doctor make. When taking amitriptyline, these must be taken into consideration:

Allergies

Discuss with your physician If you’ve ever experienced an unusual reaction or allergy to amitriptyline, or any other medications. Be sure to inform your health doctor if you suffer from other allergies, like dyes, food, or preservatives. You may also be allergic to animals. For products that are not prescription-only, you must look over the label or ingredient list carefully.

Pediatric

Studies that are appropriate have not been conducted to determine the relationship of age and adverse effects of amitriptyline children younger than 12 years old age. Safety and efficacy haven’t been established.

Geriatric

The studies that have been conducted so far have not revealed specific geriatric issues that could restrict the use of amitriptyline for the older. However, older patients tend to develop liver disorders that are a result of age, and this might require adjusting the dosage of patients receiving the medication amitriptyline.

Breastfeeding

There aren’t enough research studies on women to determine the risks to babies when taking this medication while breastfeeding. Consider the benefits and the risk of taking this medication when nursing.

Interactions between medicines

While certain medications should not be combined in any way, however, there are instances where two different medications can be taken together, even if interactions could occur. In these situations, your doctor might decide to alter the dosage or take other precautions if needed. If you’re taking amitriptyline, it’s particularly important to let your doctor know that they are using any one of these medications mentioned below. The following interactions were chosen based on their potential impact and are not all-inclusive.

Amitriptyline use in conjunction with any of the following medications is not advised. Your physician may decide to not treat you with this drug or modify one of the other medications you are taking.

Bepridil
Bromopride
Cisapride
Clorgyline
Dronedarone
Furazolidone
Grepafloxacin
Iproniazid
Isocarboxazid
Levomethadyl
Linezolid
Mesoridazine
Methylene Blue
Metoclopramide
Moclobemide
Nialamide
Pargyline
Phenelzine
Pimozide
Piperaquine
Procarbazine
Ranolazine
Safinamide
Saquinavir
Selegiline
Sparfloxacin
Terfenadine
Thioridazine
Toloxatone
Tranylcypromine
Ziprasidone

The use of amitriptyline conjunction in conjunction with any of these drugs is not usually advised, however it may be necessary in certain situations. If the two medicines are prescribed in conjunction the doctor could alter the dose or the frequency at which you take one or both of the medications.

Acecainide
Aceclofenac
Acemetacin
Albuterol
Alfentanil
Alfuzosin
Almotriptan
Amiodarone
Amisulpride
Amoxapine
Amphetamine
Amtolmetin Guacil
Anagrelide
Apomorphine
Aprindine
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Artemether
Asenapine
Aspirin
Astemizole
Atazanavir
Azimilide
Azithromycin
Benzhydrocodone
Benzphetamine
Bretylium
Bromfenac
Brompheniramine
Bufexamac
Buprenorphine
Bupropion
Buserelin
Buspirone
Butorphanol
Celecoxib
Ceritinib
Chloral Hydrate
Chloroquine
Chlorpheniramine
Chlorpromazine
Choline Salicylate
Ciprofloxacin
Citalopram
Clarithromycin
Clofazimine
Clomipramine
Clonidine
Clonixin
Clozapine
Cocaine
Codeine
Crizotinib
Cyclobenzaprine
Dabrafenib
Darunavir
Dasatinib
Degarelix
Delamanid
Desipramine
Deslorelin
Desmopressin
Desvenlafaxine
Deutetrabenazine
Dexibuprofen
Dexketoprofen
Dextroamphetamine
Dextromethorphan
Diclofenac
Diflunisal
Dihydrocodeine
Dipyrone
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Doxepin
Doxorubicin
Doxorubicin Hydrochloride Liposome
Droperidol
Droxicam
Efavirenz
Eletriptan
Encorafenib
Enflurane
Entrectinib
Epinephrine
Erythromycin
Escitalopram
Eslicarbazepine Acetate
Etodolac
Etofenamate
Etoricoxib
Felbinac
Fenfluramine
Fenoprofen
Fentanyl
Fepradinol
Feprazone
Fexinidazole
Fingolimod
Flecainide
Floctafenine
Fluconazole
Flufenamic Acid
Fluoxetine
Flurbiprofen
Foscarnet
Fostemsavir
Frovatriptan
Gatifloxacin
Gemifloxacin
Glasdegib
Glucagon
Glycopyrrolate
Glycopyrronium Tosylate
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Halothane
Histrelin
Hydrocodone
Hydromorphone
Hydroxychloroquine
Hydroxytryptophan
Hydroxyzine
Ibuprofen
Ibutilide
Iloperidone
Imipramine
Indomethacin
Inotuzumab Ozogamicin
Iobenguane I 123
Iobenguane I 131
Isoflurane
Isradipine
Ivabradine
Ivosidenib
Ketoconazole
Ketoprofen
Ketorolac
Lacosamide
Lapatinib
Lasmiditan
Lefamulin
Lenvatinib
Levalbuterol
Levofloxacin
Levomilnacipran
Levorphanol
Lidoflazine
Lisdexamfetamine
Lithium
Lofexidine
Lopinavir
Lorcainide
Lorcaserin
Lornoxicam
Loxapine
Loxoprofen
Lumefantrine
Lumiracoxib
Macimorelin
Meclofenamate
Mefenamic Acid
Mefloquine
Meloxicam
Meperidine
Metaxalone
Methacholine
Methadone
Methamphetamine
Metronidazole
Milnacipran
Mirtazapine
Mobocertinib
Moricizine
Morniflumate
Morphine
Morphine Sulfate Liposome
Moxifloxacin
Nabumetone
Nafarelin
Nalbuphine
Naproxen
Naratriptan
Nefazodone
Nefopam
Nepafenac
Niflumic Acid
Nilotinib
Nimesulide
Nimesulide Beta Cyclodextrin
Norepinephrine
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Ondansetron
Osilodrostat
Osimertinib
Oxaliplatin
Oxaprozin
Oxycodone
Oxymetazoline
Oxymorphone
Oxyphenbutazone
Ozanimod
Paliperidone
Palonosetron
Panobinostat
Parecoxib
Paroxetine
Pasireotide
Pazopanib
Peginterferon Alfa-2b
Pentamidine
Pentazocine
Phenylbutazone
Piketoprofen
Pimavanserin
Piroxicam
Pitolisant
Pixantrone
Ponesimod
Posaconazole
Pranoprofen
Procainamide
Prochlorperazine
Proglumetacin
Promethazine
Propafenone
Propoxyphene
Propyphenazone
Proquazone
Protriptyline
Quetiapine
Quinidine
Quinine
Rasagiline
Remifentanil
Revefenacin
Ribociclib
Risperidone
Rizatriptan
Rofecoxib
Salicylic Acid
Salsalate
Scopolamine
Secretin Human
Selpercatinib
Sematilide
Sertindole
Sertraline
Sevoflurane
Sibutramine
Siponimod
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Sodium Salicylate
Solifenacin
Sorafenib
Sotalol
Spiramycin
Sufentanil
Sulfamethoxazole
Sulindac
Sulpiride
Sultopride
Sumatriptan
Sunitinib
Tacrolimus
Tapentadol
Tedisamil
Telavancin
Telithromycin
Tenoxicam
Tetrabenazine
Tiaprofenic Acid
Tiotropium
Tolfenamic Acid
Tolmetin
Toremifene
Tramadol
Trazodone
Triclabendazole
Trifluoperazine
Trimethoprim
Trimipramine
Triptorelin
Tryptophan
Valdecoxib
Vandetanib
Vardenafil
Vemurafenib
Venlafaxine
Vilanterol
Vilazodone
Vinflunine
Voclosporin
Voriconazole
Vortioxetine
Zolmitriptan
Zotepine
Zuclopenthixol

The use of amitriptyline along together with the following drugs could result in an increased risk of some adverse effects, however having both medicines in combination could be the most effective treatment for you. If both medications are prescribed in conjunction the doctor could alter the dosage or the frequency you take one or both drugs.

Acenocoumarol
Arbutamine
Atomoxetine
Bethanidine
Carbamazepine
Cimetidine
Desogestrel
Diazepam
Dicumarol
Dienogest
Drospirenone
Ethinyl Estradiol
Ethynodiol
Fluvoxamine
Fosphenytoin
Galantamine
Gestodene
Guanethidine
Levonorgestrel
Mestranol
Nomegestrol
Norethindrone
Norgestimate
Norgestrel
Phenprocoumon
Phenytoin
Rifapentine
Ritonavir
S-Adenosylmethionine
St John’s Wort
Warfarin

Interactions with food, tobacco, and alcohol

Certain medications shouldn’t be taken during or near the time of having food items or eating particular kinds of food, as interactions can happen. Smoking or drinking alcohol in conjunction with certain medicines can create interactions. The following interactions have been chosen because of their potential importance and are not intended to be comprehensive.

Utilizing amitriptyline in conjunction together with the following is not recommended, however, it could be necessary in certain instances. If they are used in conjunction the doctor may alter the dosage or frequency you take amitriptyline. They may also provide specific guidelines regarding the consumption of food, tobacco, or alcohol.

Tobacco

Utilizing amitriptyline in conjunction in conjunction with any of the following could result in an increased risk of some adverse effects, but they may be inevitable in certain instances. If you take them together the doctor may alter the dosage or frequency you take amitriptyline. They may also provide you with specific instructions regarding the consumption of food, alcohol, or tobacco.

Ethanol

Other medical conditions

The presence of any other medical conditions can affect the usage of amitriptyline. Be sure to inform your physician if you suffer from any other medical conditions particularly:

Bipolar disorder (mood disorder with periodic depression and mania) or the risk of
Recent heart attack–Shouldn’t be utilized in patients with the following conditions.

Diabetes
Glaucoma
Heart disease
Thyroid hyperactivity
Schizophrenia
Seizures
Urinary retention (trouble with urination) and history of cautiousness. It can make the condition worse.

Use with care. The effect may be heightened due to the slower elimination of the medication in the human body.

Properly using Amitriptyline

Amitriptyline should be taken only according to your doctor’s instructions to improve your health as much as is possible. Do not take more than it, and don’t do more frequently, and don’t take it for any longer duration than the doctor has ordered.

Amitriptyline includes a medication manual. Take note of the information in the document attentively. Consult your physician if you have any queries¹.

Dosing

The dosage of amitriptyline is likely to differ depending on the patient. Follow the doctor’s instructions or the instructions in the prescription. This information is only the doses that are typical of Amitriptyline. If you have a different dose you should not alter it until your doctor instructs you to change it.

The quantity of medicine you consume is contingent on your strength drug. In addition, the number of doses that you are taking each day, the amount of time between doses, as well as the amount of time you use the medication depend on the medical condition for which you’re taking the medication.

For oral dosage forms (tablets):
- For depression:
  - Adults – At first 75 milligrams (mg) per day, taken in doses divided of 50-100 mg at nighttime. Your physician may alter the dosage if required. But, the dosage is generally not greater than 150 mg daily except if you are in a hospital. Certain patients in hospitals may require greater dosages.
  - Adults aged between 10 and 15 – 10 milligrams (mg) three times per day. 20 mg before bedtime. Your physician may alter the dosage as necessary.
  - Children who are younger than 12 years of age – The dosage and dosage should be determined by your physician.

Missed dose

If you have missed an amitriptyline dose, make sure to take it as soon as you can. But, if it’s close to the time for the next dose, you can skip the missed dose and then go back to your usual dose schedule. Don’t double doses.

Storage

Place the medicine in a tightly sealed bottle at room temperatures, and away from moisture, heat, and bright light. Be sure to keep the medicine from the medicine from freezing.

Keep your items out of reach of children.

Don’t keep old medicine or medicines that are no longer required.

Consult your physician to tell you how to dispose of any medication you don’t make use of.

Amitriptyline is a drug that can cause serious harm.

It is vital to have your doctor monitor your progress on a regular basis to ensure that you are able to adjust in dosage, and also to look for any undesirable negative effects.

Amitriptyline could cause some individuals to feel agitated, angry or exhibit other unusual behavior. It can also trigger individuals to experience suicidal thoughts and depressive tendencies, or be more depression. Should you, or your caretaker are aware of any of these consequences, consult your physician immediately.

Avoid taking amitriptyline after you’ve taken any monoamine oxide (MAO) inhibitor (isocarboxazid [Marplan(r)] or the phenelzine [Nardil(r) selegiline [Eldepryl(r) and tranylcypromine [Parnate(r)[Parnate(r)]) within the last 2 weeks. Do not begin taking a MAO inhibitor before 5 days after stopping the amitriptyline. In the event that you try, you might be prone to confusion, agitation anxiety, stomach or intestinal symptoms, sudden elevation of body temperature, extreme hypertension, and extreme convulsions.

Do not take any other medications until they’ve been discussed with your physician. When you take amitriptyline in combination with Cisapride (Propulsid(r)) can increase the risk of severe adverse negative effects.

Do not stop abruptly taking amitriptyline before consulting with your physician. Your doctor might advise you to gradually decrease the amount of medication you’re taking before stopping completely. This could help to prevent an eventual aggravation of your condition and decrease the risk of experiencing withdrawal-related symptoms like nausea, headache, or general feelings of illness or discomfort.

Amitriptyline can enhance alcohol’s effects as well as other CNS depressants (medicines that slow down nerves, perhaps creating the feeling of drowsiness). Examples of CNS depressants include antihistamines, remedies that treat allergies, allergies, or colds. They also include tranquilizers, sedatives or sleeping pills prescribed pain medication as well as narcotics medication for seizures; muscles relaxants or anesthetics which includes some dental anesthetics. The effect can be present for several weeks after you take amitriptyline off the market. Consult your physician prior to using any of the medications listed above while taking amitriptyline.

Prior to any type of procedure, tell the doctor who is in charge that you’re using amitriptyline. Combining amitriptyline with other medications utilized during surgery can increase the chance of having side consequences.

Amitriptyline may affect blood sugar levels. If you notice any changes in your urine or blood test for sugar or are unsure, you should consult with your doctor.

Amitriptyline could cause some people to feel drowsy. Make sure you are aware of what your reaction to amitriptyline is prior to driving, using drugs, or do anything else that may be hazardous if you’re sleepy or unaware.

Amitriptyline side effects

Alongside its necessary effects, medicines can produce unwanted side adverse effects. While not all of these negative side effects are likely to occur, if they occur, they could require medical attention.

Talk to your doctor immediately in the event that any of these adverse effects happen:

The exact cause is not known.

Stomach or abdominal pain
Affliction
Black, tarry stool
bleeding gums
Blood in urine or stool
blurred vision
burning and itching the sensation of being numb, or prickly, “pins and needles” or tingling sensations
change in consciousness
variations in the patterns and rhythms of speech
chest pain or discomfort in the chest.
chills
cold sweats
Coma
confusion
Uncertainty about identity, location, and the passage of time
continuous buzzing, ringing or some other unanswered noises in the ears
convulsions
cool, pale skin
cough or hoarseness or cough
Dark urine that is dark
less frequent the frequency of
diminution in the volume of urine
lower output of urine
difficulty breathing
difficulties in passing urine (dribbling)
problems with speaking
disturbances in accommodation
disturbed concentration
faintness, dizziness or lightheadedness when rising from a sitting or lying posture suddenly
double vision
Drooling
dry mouth
Excited
fainting
False beliefs that cannot be altered by the facts
heartbeats that are slow, fast or irregular heartbeat
anxiety or anxiety
Chills or fever
Dry, flushed skin
Fruity-like breath odor
general feeling of fatigue or weakness
headache
hearing loss
high fever
Low or high blood pressure
hostility
inability to move legs, arms or facial muscles
inability to speak
an increase in appetite
the increased need to urinate
Increased pressure in the ocular area
Increased sweating
an increase in thirst
more frequent urine production
irritability
Lack of coordination
Lethargy
Light-colored stools
lipsmacking or puckering
Appetit loss
Balance control issues
Loss of bladder control
loss of consciousness
Lower back or side or side
Anxiety or depression in the form of mental illness
muscle spasms or jerking of the entire extremity
Muscle tightness
muscle trembling, jerking, or stiffness
Muscle that is twitching
nausea and vomiting
nightmares or vivid dreams that are unusually vivid
Reflexes that are overactive
uncomfortable or painful urination
having more frequent urination
Red spots that are precise on the skin
poor coordination
A pounding sound in the ears
the churning of cheeks
fast or worm-like movements of the tongue
rapid weight gain
insanity
being able to hear, see or sense things that aren’t present
seizures
Muscle stiffness that is severe
Shaking and unsteady walk
Shivering
breathlessness
Walking in a shuffling fashion
insomnia
Slow speech
Speech slurred
sore throat
sores, ulcers, and white marks on the lips or inside the mouth
stiffness of the limbs
stupor
abrupt loss of consciousness
sweating
swelling of the face, ankles or hands
Acne swelling or puffiness
swollen glands
engaging in conversation or acting out with enthusiasm that you can’t be in control of
difficulty in speaking
difficulty sleep
Troubled breathing
The body’s twisting movements cause tension or discomfort in the muscles, jaw, or back
Inability to fall asleep
Uncontrolled chewing movement
Uncontrolled movements, particularly of neck, face, arms, and back
Unexplained weight loss that is not explained
Bad breath unpleasant breath
unstable, trembling, or other motor control, coordination, or muscle strength
unusual bleeding or unusual bleeding or
unusual fatigue or weakness
very pale skin
Upper right abdominal discomfort in the upper right abdominal
Vomiting of blood
weak hands, arms, or legs
weight loss or gain
Yellow eyes and skin

Seek emergency assistance immediately in the event that any of the following signs of overdose develop:

Symptoms of Overdose

Clumsiness
Drool
lower body temperature
Muscle aches
Muscle weakness
insomnia
tiredness
A weak, sluggish pulse

Certain side effects can be experienced but they usually do not require medical treatment. These side effects can be eliminated when your body adjusts the medication. Additionally, your health professional could be able to inform you of ways to avoid or minimize certain adverse effects. Consult your doctor for any of these adverse effects that persist or are troubling or if there are any concerns about these: