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Genric Name: Donepezil

Dosage Form Transdermal System

Medically reviewed by A Rash, MD.  Updated on Mar 22, 2022.

What exactly is Adlarity?

Adlarity(Donepezil) increases the functionality of nerve cells within the brain. It does this by stopping the breakdown of a chemical known as Acetylcholine  People suffering from dementia typically are less able to absorb this substance which is crucial for cognitive processes that affect memory as well as thinking and reasoning.


  • Adlarity is a prescription medication that is used to treat mild, moderate, and severe Alzheimer’s kind.
  • It isn’t known whether this medicine has been proven safe or effective for children.

Who shouldn’t use Adlarity?

It is not recommended to make use of Adlarity If you

  • There are people who are allergic to donepezil, or medications which contain piperidines. Check out the bottom of this page to find an exhaustive list of the components.
  • I have experienced an allergic skin reaction, which is known as contact dermatitis Adlarity

Talk to your doctor If you’re not sure whether you should utilize this method. Adlarity transdermal device.

Mechanism of Action

The therapeutic action of adlarity is thought to be due to an increase in cholinergic activity. This is performed by reversibly inhibiting acetylcholinesterase hydrolysis, hence boosting the quantity of acetylcholine. There is no indication that donepezil affects the progression of the dementing process.

Prior to using Adlarity


Before starting treatment, inform your doctor about your medical issues, including those that:

  • are suffering from heart issues have any heart issues, for example, irregular rapid, slow heartbeats, or irregular heartbeats.
  • are suffering from stomach ulcers.
  • Have issues in passing urine.
  • have seizures.
  • are suffering from asthma or have other lung issues.
  • You are expecting or plan to get pregnant. It’s not clear whether Adlarity could cause harm to your baby.
  • If you are nursing or planning to or plan to. It’s unclear whether Adlarity is absorbed into breast milk.

What other drugs can alter Adlarity?

Discuss with your doctor every medicine you are taking that you are taking, including prescription and non-prescription medications such as vitamins, herbal supplements. Adlarity could affect the way other medications function and also other medications could affect the way Adlarity operates.

Inform your healthcare professional that you are taking medicines known as nonsteroidal anti-inflammatory medicines (NSAIDs) like Ibuprofen, aspirin, naproxen (Aleve), and celecoxib. diclofenac and indomethacin and more.

Contact your physician for advice if you’re not certain which of your medicines are NSAIDs. If you take both NSAIDs and Adlarity together can increase the risk that you develop stomach ulcers.

The combination of Adlarity with certain drugs that are used to anesthetize patients can cause adverse negative effects. Be sure to inform your healthcare professional or dentist about this Adlarity transdermal system prior to when you are:

  • surgery
  • medical procedures
  • dental procedure or surgery

Learn about the medicines you are taking. Keep a record of all of your medications. Provide it to your healthcare professional prior to starting any new medication.

How to use Adlarity?

Check out instructions for use included with your prescription to get step-by-step directions on applying, taking, and disposing of Adlarity.

  • Utilize Adlarity precisely as your doctor tells you to use it.
  • The Adlarity transdermal device is meant for use only on the skin.
  • Apply 1 transdermal treatment at a given time to your skin one time per week (every seven days).
  • Apply the cream to dry, clean and healthy skin that has minimal or no hair.
  • In the event that your transdermal device is falling off or you don’t get a dose, you should apply an entirely new transdermal system now. Remove the transdermal area 7 days after.
  • If you decide to stop treatment or stop taking medication, contact your healthcare professional for advice before starting the process.
  • In the event of an overdose seek medical attention or dial the poison helpline immediately.

Dosing information

Normal Adult Dose to Treat Alzheimer’s Disease

The recommended starting dose is 5 mg per day. After 4 to 6 weeks the dosage could be increased until the maximum recommended dose of 10 mg/day.
If a patient was taking oral donepezil at a dose of 5 mg per day during at minimum 4-6 weeks, or taking 10 mg/day of orally administered donepezil. The suggested starting dose will be 10 mg daily.
Administer Adlarity as a transdermal treatment applied on the skin weekly.

Treatment for moderate, mild, or severe Alzheimer’s type.

What should I be aware of when using Adlarity?

  • Avoid touching your eyes after handling the transdermal system. If you come into contact between your eyes or if your eyes turn red after touching the transdermal device, rinse your eyes with water, and seek medical attention if the symptoms persist.
  • Avoid contact with heat sources like excessive sunlight saunas, sunrooms, or heating pads for prolonged durations of time. The excess amount of medicine may be in the body.

Side effects of Adlarity

Adlarity could have serious reactions, including:

  • Skin reactions. Redness and itching can occur on the site of the application. Make sure to stop treatment and contact your physician in the event that you experience any of these reactions that do not improve within two days (48 hours) after the transdermal system has been eliminated:
    • more swelling or redness
    • Blistering or peeling of the skin
    • Spreading beyond the site of application
  • The heart rate is slow and you feel faint. Contact your doctor immediately if you feel lightheaded or faint.
  • A higher level of stomach acid. This can increase the risk of bleeding and ulcers. The risk is greater for certain individuals including those who have suffered from ulcers or are taking NSAIDs. Contact your doctor immediately if you notice any of these signs:
    • stomach pain or heartburn that isn’t old or persists.
    • nausea or vomiting and bloody vomit or dark vomit that appears like coffee grounds.
    • stool that appears like black the color of tar.
  • Problems passing urine. Contact your healthcare professional immediately if you experience issues with passing urine.
  • Seizures. Contact your doctor immediately if you experience seizures.
  • In the case of those suffering from asthma or other lung diseases. Consult your physician in case you’re experiencing recent or worsening lung issues.

The most frequent adverse reactions of donepezil the medication in Adlarity The most frequent side effects of donepezil are:

They aren’t all the possible adverse negative effects. Consult your physician for advice regarding medical adverse effects. You can report any adverse reactions to the FDA by calling 800-FDA-1088.

How do I how should I store Adlarity?

  • The transdermal system should be stored in the fridge between 36degF and 46degF (2degC to 8degC).).
  • Do not keep in the freezer.
  • Place the transdermal system in its sealed pouch until it is ready to use.

Keep all medications out of reach of pets and children.

General information on the safe and efficient usage of Adlarity.

Sometimes, medicines are prescribed for different reasons than those described in the Patient Information leaflet. Don’t use this medication for any medical condition for which it is not recommended. Don’t offer it to anyone else regardless of whether they are suffering from the same symptoms as you are suffering from. They could be harmed by it. You may request from your physician specific information written specifically for healthcare experts.

Patient counseling

Recommend reading the FDA-approved patient labeling (Patient Information and Instructions for Use) to the patient or caregiver.

  • Instructions for Administration
  • Instruct patients or caregivers on the necessity of using the proper dosage on the proper body spot. Instruct patients or caregivers to apply the transdermal system to clean, dry, undamaged, healthy skin with little hair (sparse, fine hair is OK) and rotate the application site to avoid skin irritation.
  • Within 14 days, do not utilize the same precise body area, although another section of the same anatomic site (e.g., the back) may be used in consecutive weeks. Before applying a fresh transdermal system to a different skin site, the prior week’s transdermal system must be removed. Allow the bag to come to room temperature before using it. Every 7 days, ADLARITY should be refilled. At any one moment, only one transdermal system should be worn.
  • Instruct patients or caregivers to avoid exposing the transdermal system to external heat sources for extended periods of time (excessive sunshine, saunas, solariums, heat pads).
  • Dose Missed
  • Instruct patients who miss a dose to apply a new transdermal system right away and then replace it 7 days later at the regular application time to begin a new cycle. Instruct patients that they should not use two transdermal systems to make up for a missing one.
  • If therapy has been halted, tell the patients or carers to call a physician for titration instructions.

Discarding Old Transdermal Systems

  • Instruct patients or caregivers to fold the transdermal system in half and throw it away after each use, out of reach and sight of youngsters and dogs. Instruct patients or caregivers that the medicine stays in the transdermal system after seven days of use and that used transdermal systems should not be flushed. Instruct patients or caregivers to avoid making eye contact with the transdermal system and to wash their hands after touching it.
  • If they come into touch with their eyes by mistake or if their eyes get red after handling the transdermal system, they should immediately rinse with lots of water and seek medical help if the symptoms do not go away.

Reactions on the Skin

  • Patients or carers should be informed about the possibility of allergic contact dermatitis responses. Instruct patients or caregivers to contact a healthcare provider if site reactions spread beyond the transdermal system’s application site if there is evidence of an intense local reaction (e.g., increasing erythema, edema, papules, vesicles), and/or if symptoms do not improve significantly within 48 hours after removing the transdermal system.


  • Inform patients that if they are pregnant or intend to become pregnant, they should tell their healthcare professional.

Additional details

Always consult your doctor to confirm that the information provided on this site is appropriate to your particular situation.

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