Generic name: Alteplase
Brand name: Activase, Cathflo Activase
Drug class: Thrombolytics


Actilyse (Activase) is a tissue plasminogen activator (t‑PA) produced by recombinant DNA technology. It is a sterile, purified glycoprotein of 527 amino acids. It is synthesized using the complementary DNA (cDNA) for natural human tissue‑type plasminogen activator (t‑PA) obtained from an established human cell line.

actilyseThe manufacturing process involves secretion of the enzyme Activase into the culture medium by an established mammalian cell line (Chinese hamster ovary cells) into which the cDNA for Activase has been genetically inserted

Activase injection is a sterile, white to pale yellow, lyophilized powder for intravenous administration following reconstitution with Sterile Water for Injection, USP.


Activase is an enzyme (serine protease) that has the property of fibrin-enhanced conversion of plasminogen to plasmin. It produces limited conversion of plasminogen in the absence of fibrin. Activase binds to fibrin in a thrombus and converts the entrapped plasminogen to plasmin, thereby initiating local fibrinolysis

In patients with acute myocardial infarction administered 100 mg of Activase as an accelerated intravenous infusion over 90 minutes, plasma clearance occurred with an initial half‑life of less than 5 minutes and a terminal half‑life of 72 minutes. Clearance is mediated primarily by the liver.

Mechanism of action

Indications and Usage

Acute Ischemic Stroke

Acute Myocardial Infarction

Pulmonary Embolism


Activase should not be administered to patients with known hypersensitivity to Activase or any component of the formulation

Precautions and warnings






Drug Interactions

Carcinogenesis, Mutagenesis, Impairment of Fertility


Nursing Mothers

Pediatric Use

Geriatric Use

Activase side effects

 Allergy such as Hives and breathing problems and swelling of your lips, face, and tongue.

Consult your physician or seek medical attention in an emergency situation If you are experiencing indications of bleeding, for example:

Make sure to contact your doctor at the earliest opportunity if you are suffering from:

Dosage and Administration

Acute Ischemic Stroke

Acute Myocardial Infarction

Acute Massive Pulmonary Embolism

Stability and Storage

Store lyophilized Activase at refrigerated temperature (2–8°C/36–46°F). Do not use beyond the expiration date on the vial. Protect the lyophilized material during extended storage from excessive exposure to light.

If I don’t take the dose?

Since you’ll be receiving Activase in a medical environment, you’re less likely to skip the dose.

If I consume too much?

Get medical attention immediately or contact for help at the Poison Help line at 1-800-222-1222.

What other medications can affect the action of Actilyse?

Discuss with your doctor all other medications including:

This list isn’t complete. Other medications can affect Activase, which includes medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs that are included here.

Additional details

Be sure to keep this medication and other medications out of reach of children. Never give your medication to anyone else and take this medication only for the purpose prescribed.

Always consult your doctor to confirm that the information provided on this site is appropriate to your particular situation.

How Supplied


Alteplase side effects

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