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Name of generic: hydrochlorothiazide and quinapril

Brand name: Accurate
Class of drugs: ACE inhibitors with Thiazides

What is Accuretic?


Accuretic is a mixed medicine for treating hypertension ( high blood pressure) It is a combination of hydrochlorothiazide and quinapril. Hydrochlorothiazide is a diuretic thiazide (water pills). Quinapril is the category of an ACE inhibitor (ACE is an acronym for the angiotensin-converting enzyme). Lowering blood pressure can reduce your chance of suffering stroke, or coronary heart attack.

Accuretic is also used for reasons not mentioned in this guideline for medication.


  • Do not take this medication when you are pregnant. If you find yourself pregnant and discontinue taking Accuretic and consult your physician immediately.
  • It is not recommended to use this medication if you’ve ever suffered from angioedema or if you’re not able to urinate or if intolerant to sulfa medications or the ACE inhibitor. Do not use Accuretic within the first 36 hours of or after taking a medicine that includes sacubitril (such as Entresto).
  • If you are diabetic take care not to take Accuretic in conjunction with any other medicine that includes the ingredient aliskiren (a blood pressure medication).

Before taking this medication, you must consult your physician.

This medicine if your body is allergic to quinapril or hydrochlorothiazide, or if

  • If you’ve had a previous background in angioedema
  • If you’re unable to go to the bathroom;
  • You recently had an anti-heart medicine known as sacubitril.
  • If you’ve ever experienced an extreme allergic reaction with one of the ACE inhibitors (benazepril captopril fosinopril, lisinopril moexipril, or ramipril).

Avoid taking Accuretic in the first 36 hours prior to or after taking a medicine that includes sacubitril (such as Entresto).

If you suffer from diabetes don’t make use of an Accuretic in conjunction with any other medication that includes the ingredient aliskiren (a blood pressure medication).

It may be necessary to steer clear of taking Accuretic with the aliskiren when you suffer from kidney problems.

Speak to your doctor if have ever suffered from:

  • Kidney disease (or if you’re taking dialysis);
  • Cirrhosis or other liver diseases;
  • glaucoma;
  • congestive heart failure;
  • gout;
  • lupus;
  • an allergy to sulfa-based drugs or penicillin
  • If you’re following an e-diet that is low in salt.

Avoid using when you are pregnant. Take a break from the medicine and notify your doctor when you discover you are pregnant. Quinapril can cause injury or even death to the unborn baby if you use the medication in the third or second trimester.

It is not recommended to breastfeed during the use of an Accuretic.

Accuretic is not permitted for use for anyone who is younger than 18 years old.

Indication and usage


ACCURETIC is recommended for the treatment of hypertension, and to reduce blood pressure. The reduction in blood pressure decreases the chance of death and non-fatal cardiovascular events, including myocardial and stroke. These benefits have been observed in controlled studies of antihypertensive medications from a range of classes, including the class that this drug is a part of. There aren’t any controlled trials showing risk reduction using ACCURETIC.

The control of high blood pressure is an essential and integral part of the comprehensive prevention of cardiovascular risk, including the appropriate managing diabetes, lipid control treatment for antithrombotic issues smoking cessation, exercise, and a restricted intake of sodium. Most patients will require multiple drugs to reach their blood pressure targets. For specific guidance on the goals and how to manage them follow the guidelines published, like those of the National High-Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).

A variety of antihypertensive medicines, comprising various pharmacologic classes and with various mechanisms of effect, have been demonstrated in controlled studies randomized to decrease cardiovascular morbidity and mortality. It is possible to conclude that it is the reduction in blood pressure and not another property of the drug which is the main reason for the advantages. The most significant and consistent benefit to cardiovascular outcomes is a decrease in the chance of having a stroke and myocardial infarction, and mortality from cardiovascular causes is also seen frequently.

The elevated diastolic and systolic pressure can increase the risk of heart disease and the risk of increasing the risk per mmHg is higher for blood pressures that are higher and, therefore, even small reductions in severe hypertension could be beneficial in a significant way. The risk reduction associated with blood pressure reductions is similar to a variety of populations, with different risks, and the benefits are higher for those at greater risk irrespective of hypertension (for instance, those suffering from hyperlipidemia or diabetes) These people are expected to gain from an aggressive approach to lower blood pressure target.

Certain antihypertensive medicines have lower blood pressure-related impacts (as monotherapy) for black patients as well as many antihypertensive medicines are approved for additional benefits and indications (e.g. for the heart, angina, or diabetes kidney diseases). These aspects can guide the selection of treatment.

This fixed combination isn’t suggested for the treatment of high blood pressure 

In using ACCURETIC, consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that quinapril does not have a similar risk.


Angioedema in Black Patients

Black patients who receive ACE inhibitors in monotherapy have been found to be more likely to suffer from angioedema when compared with non-blacks. It is important to remember the fact that, in clinical studies controlled by a physician ACE inhibitors exert a positive influence on blood pressure, which appears to be lower for black patients than non-blacks.

How do I prepare for Accuretic?

Follow the directions on your prescription label, and go through all medication guides or instructions sheets. Your doctor may alter your dosage. Make sure you take the medicine precisely as directed.

Contact your physician if you are suffering from persistent diarrhea or have more sweating than usual. It is possible to become dehydrated when you take Accuretic. This could result in high blood pressure or electrolyte issues or kidney failure.

Your blood pressure needs to be checked regularly and you might require regular blood tests.

If you require surgery, tell your doctor you’re currently taking this medicine.

Use this medication as prescribed even if you don’t are feel good. High blood pressure can have no signs. It is possible that you will need blood pressure medications throughout your life.

Keep at room temperature, free of heat, moisture, and light.

If I don’t take a dose?

Do not take the medicine for as long as you are able, but do not take any missed doses if you are nearing the time to take the next dose. Don’t have two doses at one time.

If I consume too much?

Get medical attention immediately or contact toll-free the Poison Help line at 1-800-222-1222.

What should I be aware of when taking Accuretic?

Hydrochlorothiazide could increase your chance of developing skin cancer. Avoid tanning beds or sunlight. Be sure to wear protective clothing and apply sunscreen (SPF 30 or greater) whenever you’re outside. Your doctor might ask you to take skin tests every few months.

Drinking alcohol may increase your blood pressure, and can also increase the negative effects of an Accuretic.

Don’t use sodium substitutes, or potassium supplementation when using this medication unless your doctor has instructed you to.

Do not get up too quickly from a lying or sitting place, as you could be dizzy.

Avoid becoming too hot or dehydrated during workouts during hot weather or by drinking insufficient fluids. Follow the advice of your physician about the kind and quantity of fluids you must consume. In certain situations drinking too much fluid could be as harmful as drinking insufficiently.

Accurate adverse effects

Seek medical attention immediately If you notice symptoms that indicate an allergic reaction (hives or stomach pains that are severe and breathing difficulties or a swelling of your throat or face) or an extreme skin reaction (fever or sore throat, burning sensations in your eyes, skin irritation and an ailment or redness which spreads and leads to blistering as well as peeling).

You are more likely to suffer from allergies if are an African-American.

Consult your physician immediately in the event that you are suffering from:

  • A feeling of lightheadedness, as if you’re about to pass out.
  • blurred vision pain or seeing halos of light;
  • swelling of the body, weight increase, breath shortness;
  • A sudden feeling of weakness or discomfort like chills, fever, or chills. Sore throat mouth sores, trouble swallowing;
  • high potassium- nausea sensation, tingling chest pain, and irregular heartbeats. Also loss of motion;
  • lower potassium level, leg cramps constipation, irregular heartbeats, fluttering of your chest, thirsty or increased the need to urinate, numbness or sensation of tingling, muscle weakness, or a feeling of limpness;
  • low levels of sodium- headache and confusion. Also and slurred speech. weakness vomiting in coordination loss, feeling unstable.

Common side effects could be:

  • cough;
  • headache, dizziness;
  • exhausted feeling tired feeling
  • muscle pain.

This isn’t a complete list of all side effects. other side effects could occur. Contact your doctor for advice regarding medical adverse effects. You can report symptoms to FDA at 1-800-FDA-1088.

Additional details

Keep this medication and other medications out of reach of children. Do not divulge your medications to others and use this medicine only to treat the condition prescribed.

Always consult your physician to confirm that the information provided on this page is applicable to your specific situation.


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