Generical name: sacubitril and Valsartan
Class of drugs: Angiotensin receptor blockers and Neprilysin inhibitors
Oral route (Tablet)
Drugs that affect directly the renin-angiotensin pathway could result in fatal injuries or even death. Stop using as soon as the pregnancy is confirmed.
In the U.S.
Available Dosage Forms:
Therapeutic Class: Neprilysin Inhibitor/ARB Combination
Pharmacologic Class: Angiotensin II Receptor Antagonist
Uses for Entresto
Entresto, Sacubitril and valsartan mixture is combined with other medications to treat heart failure that is chronic in adults. It also cuts down on hospital visits due to heart conditions. It can also be used to treat symptoms of heart failure in children one-year-old or older.
This medication is only available on prescription from your physician.
Before making use of Entresto
When deciding whether to take a medication, the potential risks of taking the medicine have to be evaluated against the good it can do. It is a choice you and your physician will take. To determine the appropriate medicine to be considered, the following factors should be assessed:
Discuss with your physician whether you’ve had an unusual reaction or allergic reaction to this medicine, or any other medication. Inform your health care specialist if you suffer from any other kinds of allergies, for example, to dyes, food preservatives, animals, or dyes. For products without a prescription, review the label or the ingredient list carefully.
The studies that have been conducted up to now have not identified specific problems for children that could limit the efficacy of sacubitril or the combination of valsartan for children 1-year-old and over.
The studies that have been conducted up to now haven’t revealed the existence of geriatric-specific issues that hinder the effectiveness of valsartan and sacubitril in older patients.
Studies on women who breastfeed have shown harmful effects on infants. Different medication is to be prescribed, or you should cease breastfeeding while taking this medication.
Interactions with medications
Certain medicines shouldn’t be combined in any way In other instances, two medicines can be taken together, even though interactions could occur. In these situations your doctor might want to alter the dosage, or make other precautions required. If you are taking this medication it is essential that you inform your healthcare provider whether you’re currently taking one or more of the medications that are listed below. The following interactions were chosen based on their potential importance and are not meant to be comprehensive.
The use of entresto together with any of the following medications is not advised. Your doctor could choose not to prescribe this medication or modify any other medication you are taking.
Utilizing this medicine in conjunction together with any of the following medicines is typically not advised, however it may be required in certain instances. If both medications are prescribed at the same time the doctor could alter the dosage or the frequency you take either of the medications.
- Potassium Phosphate
The combination of this medication in conjunction with one of the following medications could result in an increased risk of some adverse effects, however using both medicines could be the best option for you. If both medications are prescribed by your doctor, they could alter the dosage or frequency at which you take either or both drugs.
- Choline Salicylate
- Flufenamic Acid
- Mefenamic Acid
- Niflumic Acid
- Nimesulide Beta Cyclodextrin
- Propionic Acid
- Salicylic Acid
- Sodium Salicylate
- Tiaprofenic Acid
- Tolfenamic Acid
Interactions with alcohol, tobacco, or food
Certain medications are not recommended to be taken at or near the time of dining out or eating specific kinds of food as interactions could happen. The use of tobacco or alcohol together with certain medications can create interactions. Discuss with your physician the interaction of your medication in conjunction with alcohol, food or tobacco.
Other medical issues
The presence of medical issues could impact the effectiveness of this medication. It is important to inform your doctor if there are any other medical conditions including:
- Angioedema that is caused by ACE inhibitors or ARB treatment and history of
- Patients with diabetes who are also taking aliskiren (Tekturna(r))–Should not be used in patients with these conditions.
- Kidney disease, whether severe or
- Moderate Liver Disease. Use with care. The adverse effects could be increased due to the slower elimination of the medication in the human body.
- Liver disease severe, not recommended for patients suffering from this type of condition.
Proper use of Entresto
The medicine should be taken exactly as instructed by your physician. Don’t take more of it, and don’t use it more frequently and don’t take it for more period of time than the prescription your doctor gave you. Doing so could increase the likelihood of having side consequences.
The medicine includes a patient information insert. Follow the directions carefully. Consult your physician if you have any concerns.
If your child is unable to swallow tablets, the pharmacist will mix this medication into liquid suspension. Shake the suspension thoroughly for at least 10 seconds prior to giving it to your child.
Discuss with your physician whether you’ve had an unusual reaction or reaction to this medication or any other medication. Be sure to inform your health doctor if you are suffering from other kinds of allergies, for example, to dyes, food preservatives, animals, or dyes. For non-prescription medications, look over the label or the ingredients on the package carefully¶.
- For oral dosage form (tablets):
- Heart failure can be caused by:
- For patients who are taking Entresto(r) together with an ACE inhibitor or ARB:
- Adults: At first, 1 tablet is 49 milligrams (mg) of sacubitril as well as 50 mg of Valsartan, 2 times per day. After two to four weeks, your physician can increase the dose if needed and if it is tolerated. However, the dose should generally not more than 1 tablet Entresto(r) at 97/103 mg twice times per day.
- Children aged 1 year and over and weigh at least 50 kg (kg)–Dose is determined by body weight and should be determined by your physician. The recommended starting dosage is one tablet of Entresto(r) 49/51 mg 2 times per each day. Your doctor may raise your dosage every 2 weeks as required and if it is tolerated. The dose should generally not more than one tablet of Entresto(r) at 97/103 mg twice every daily.
- Children aged 1 year and over and who weigh at least 40kg or less than 50 kg. Dose is based on body mass and should be determined by the physician. The recommended starting dosage is one tablet Entresto(r) 26 mg or 24 mg twice times daily. Your doctor may raise your dosage every two weeks, if necessary and as is tolerated. The dose should typically not more than three tablets of Entresto(r) 24/26 mg twice every day.
- Children aged 1 year or older, weighing less than 40kg–Dose is based on body mass and should be determined by a doctor. The recommended dose for children is 1.6 mg per kilogram of body weight twice every day. Your doctor may increase the dose every two weeks if needed and is tolerated. But, the dosage is generally not higher than 3.1 mg per kilogram of body weight, twice each day.
- Children less than one year old–Dose and dosage should be approved by your physician.
- For patients who aren’t already taking ACE inhibitor, or an ARB or those who have previously taken very low doses of ACE inhibitors or ARB:
- Adults–At first, half a tablet Entresto(r) 49/51 mg, two times daily. After 2 to 4 weeks your doctor could increase the dose if required and as tolerated. However, the dosage is typically not more than 1.25 tablets of Entresto(r) 2 mg/97 mg times per daily.
- Children aged 1 year or older, weigh at least 50 kg (kg)–Dose is determined by weight, and should be determined by your physician. The initial dose is 1 tablet Entresto(r) 49/51, two times every day. Your physician will raise your dosage every two weeks if needed and you are able to tolerate it. But, the dosage is generally not more than one tablet of Entresto(r) 2 mg 97/103 times per daily.
- Children aged 1 year or older, who weigh at least 40kg or less than 50 kg – Dose is determined by body weight and should be determined by your physician. The recommended dose for children is 0.8 mg per kilogram of body weight, twice every daily. Your physician may increase the dose every two weeks as required and if it is tolerated. But, the dosage is typically not more than three tablets of Entresto(r) 24/26 mg twice every day.
- Children aged 1 year and over and weight less than 40kg–Dose is based on body mass and should be determined by your physician.
- Children less than one year old–Dose and dosage should be determined by your doctor.
- For patients who are taking Entresto(r) together with an ACE inhibitor or ARB:
- Heart failure can be caused by:
If you are missing an dose of this medication make sure you take it as quickly as you are able. But, if it’s nearing the time to take your next dose, avoid the missed dose and then go back to your usual dosage schedule. Do not take double doses.
Keep your items out of reach of children.
Don’t keep old medicine or medicines that are no longer required.
Consult your physician about what you can do with any medication you don’t make use of.
Place the medication in a sealed bottle at room temperatures, and away from moisture, heat, and bright light. Be sure to keep the medicine from getting frozen.
The oral suspension can be stored at ambient temperatures for up to 15 days. Do not freeze.
Use with caution when using Entresto
It is crucial to have your doctor examine the progress of your child or yourself regularly to ensure that this medication is functioning correctly. Urine and blood tests could be necessary to detect unintended adverse effects.
If you take this medication when you are pregnant may affect your unborn baby. Utilize a reliable method that prevents birth to stop from becoming pregnant. If you suspect you’ve been pregnant while taking this medication, notify your doctor as soon as possible.
Take this medication for at least 36 hours prior to or after taking an ACE inhibitor medication.
Dizziness, lightheadedness or fainting can be experienced, particularly if you suddenly get up from a sitting or lying position , or have taken diuretics (water pills). Be aware of what your reaction is to this medication before you drive, operate machines, or perform any other activity that is risky when you feel dizzy. If you experience dizziness then lie down so that you don’t faint. After that, take a few minutes to sit before getting up to stop your dizziness returning.
Talk to your physician prior to you take any supplements, medicines or salt substitutes that contain potassium..
Don’t take any other medication without discussing them with your physician. This includes prescription and non-prescription (over-the-counter OTC) medications as well as herbal or vitamin supplements.
Entresto side effects
Alongside its necessary effects, some medicines may produce unwanted side adverse effects. While not all negative side effects are likely to occur, if they occur, they might require medical attention.
Talk to your doctor immediately in the event that any of these adverse effects happen:
- Pain in the stomach or abdomen
- blurred vision
- difficulty breathing
- faintness, dizziness, or lightheadedness when rising quickly from a sitting or lying or seated
- irregular heartbeat
- nausea or vomiting
- Tingling or numbness in the feet, hands or on the lips
- unusual weakness or fatigue
- weakening or heavyness of the legs
- Urine with blood
- reduced frequency or quantity of less urine
- an increase in thirst
- Appetit loss
- Side or lower back discomfort
- swelling of the fingers, face or lower legs
- weight gain
- A large, hive-like swelling that covers the eyelids, face mouth, lips and throat, hands feet, legs or sexual organs
There are some side effects that can occur which usually don’t require medical treatment. These symptoms may disappear after treatment, as the body adapts the medication. Additionally your health professional could be able inform you ways to avoid or minimize the effects of these adverse side effects. Consult your physician in the event that any of these adverse effects persist or are troubling or if you have concerns about these:
Other adverse side effects that are not listed could also be present in certain patients. If you observe any other side effects, you should consult with your doctor.
Contact your doctor to seek medical advice on possible side effects. You can report any symptoms to the FDA at 1-800-FDA-1088.
Always consult your doctor to make sure the information presented on this site is appropriate to your particular situation.