Urokinase 

Generic name: urokinase
Drug class: Thrombolytics

Brands names

In the U.S.

• Urokinase
• Kinlytic

Pharmacologic Class: Tissue Plasminogen Activator

Uses for Urokinase

Urokinase injections are used to break up blood clots that form in the lung (pulmonary embolism).

The medicine was only available upon prescription by your physician.

This medication is not currently readily available within the United States as of October 2010.

Before taking Urokinase

When you decide to take medication, the potential risks of taking the medicine have to be evaluated against the benefits it can bring. It’s a decision that both you and your physician will take. To determine the appropriate medicine it is important to take the following into assessed:¶

`Allergies

Inform your doctor If you’ve ever experienced an unusual reaction or an allergic reaction to this medicine, or any other medication. Be sure to inform your health specialist if you suffer from any other allergies, for example, to dyes, food or preservatives. You may also be allergic to animals. For non-prescription medications, review the label or the ingredient list carefully.

Pediatric

The right studies haven’t been conducted on the relation of age to the effect of urokinase in the children’s population. The safety and effectiveness of the injection have not been confirmed.

Geriatric

There is no information available about the connection between age and the effect of urokinase in patients with geriatric diseases.

Breastfeeding

There are no studies that are sufficient of women that can determine the risk to infants when taking this medication while breastfeeding. Consider the benefits and the risks that could be associated with using this medication during nursing.

Interactions with medications

Certain medicines shouldn’t be taken together In other instances, two medicines could be combined even though there is a chance of interaction. In these instances, your doctor might want to alter the dosage or make other precautions needed. If you are taking this medication, it is particularly important to let your doctor know that there is a connection between any one of these medications that are listed below. These interactions have been chosen based on their potential importance and may not be all-inclusive.

The use of this medication in conjunction with any of these medications is not advised. Your doctor might decide to not treat you with this medicine or alter any other medication you are taking.

• Defibrotide

Utilizing this medicine in conjunction together with any of the following medications is typically not recommended, but it could be necessary for certain situations. If two medicines are prescribed in conjunction and your doctor recommends a change in the dose or the frequency at which you take one or both of the medications.

• Acenocoumarol
• Alteplase, Recombinant
• Anistreplase
• Apixaban
• Ardeparin
• Argatroban
• Bemiparin
• Betrixaban
• Bivalirudin
• Certoparin
• Dabigatran Etexilate
• Dalteparin
• Danaparoid
• Desirudin
• Edoxaban
• Enoxaparin
• Fondaparinux
• Heparin
• Lepirudin
• Nadroparin
• Parnaparin
• Pentosan Polysulfate Sodium
• Phenindione
• Phenprocoumon
• Protein C
• Reteplase, Recombinant
• Reviparin
• Rivaroxaban
• Streptokinase
• Tenecteplase
• Tinzaparin
• Warfarin

Interactions with alcohol, tobacco, or food

Certain medications are not recommended to be taken at or near the time of dining out or eating specific kinds of food, as interactions can happen. The use of tobacco or alcohol along with certain medicines can result in interactions. The following interactions have been chosen because of their potential importance and may not be all-inclusive.

Other medical issues

The presence of any other medical issues could impact the effectiveness of this medication. Be sure to inform your doctor if there are any other medical conditions particularly:

• A past history of bleeding from any body part or
• Problems with blood vessels (e.g. aneurysm) or
• Brain tumours, brain disease or
• Hypertension (high blood pressure)  or
• Stroke Recent (within 2 months) or
• Injury or surgery to the spine or brain or spine, in the last two months (within 2 months) or
• Traumas that include CPR (cardiopulmonary Resuscitation) is recent and should not be utilized in patients suffering from these conditions.

• Blood clotting disorders or
• Eye problems due to diabetes (e.g. hemorrhagic or hemorrhagic retina) or
• Infections or heart disease (e.g. endocarditis, mitral stenosis) or
• Injections into blood vessels or
• Kidney disease, whether severe or
• Liver disease, serious or
• Inserting any tube inside the body
• Any injury or surgery or injury of all kinds, serious and recent, the risk of bleeding that is serious could be more likely.

• A history of high cholesterol and the risk of suffering from a severe negative side effect is higher.

Proper use of Urokinase

A physician or other qualified medical professional will provide you with the medicine. The medicine is given via the injection of a needle inside your vein.

Use caution when making use of Urokinase

Urokinase causes bleeding that generally isn’t serious. However, severe bleeding can occur in certain people. To avoid serious bleeding ensure you follow the guidelines that your doctor gives you. Do as little movement as you can. Also, don’t get off your bed by yourself unless you are told by your doctor that it’s fine to do this.

Be aware of any bleeding or oozing that may be visible on your skin, like around the site of injection or the site where blood was taken through your arm. Also, be sure to check for blood in your bowel movements or urine. If you experience injuries or bleeding, inform your physician or nurse immediately.

Urokinase side effects

Alongside its necessary effects, some medicines may result in unwanted side adverse effects. While not all of these negative side effects are likely to occur, if they occur, they might require medical attention.

Consult your physician or nurse right away when any of these adverse effects happen:

More popular

• Bleeding gums
• The coughing up of blood
• difficulties swallowing or breathing
• dizziness
• headache
• Vaginal bleeding
• nosebleeds
• paralysis
• long-term bleeding from cuts
• Black or red stool with tarry or black
• Urine that is dark brown or red
• breathlessness

Rare

• Cough
• fast heartbeat
• Heresies or warts
• Itching skin
• loud breathing
• The swelling or puffiness of the eyelids and around the lips, eyes, face or tongue
• Redness on the skin
• the skin itchy rash
• Tightness in the chest
• unusual weakness or fatigue
• wheezing

Incidence unknown

• Fingernails and blue lips
• blurred vision
• chest pain or discomfort in the chest.
• confusion
• convulsions
• The coughing can produce a pinkish frothy sputum
• hard, rapid or noisy breathing often with wheezing
• fainting
• quick or irregular, pounding or racing heartbeats
• inability to speak
• more sweating
• Low blood pressure or pulse
• Tingling or numbness in the arms, face or legs
• pale skin
• severe or sudden headache
• extreme ou sudden weakness or weakness leg or arm on the opposite or both sides of your body
• Speech slurred
• swelling of the legs as well as ankles
• difficulties with speaking or walking
• unconsciousness

Other adverse side effects that are not listed could also be present in certain patients. If you observe any other symptoms, consult with your doctor.

Contact your doctor for advice from a medical professional regarding possible side effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

More details

Always consult your doctor to make sure the information presented on this site is appropriate to your particular situation.