Quviviq

Generic Name: daridorexant
Dosage Form: tablets, for oral use

Medically reviewed by A Ras.  Updated on  March 27, 2022.

What is Quviviq?

Quviviq is a prescribed medicine for adults who are having trouble getting asleep or remaining in bed (insomnia).

It isn’t clear whether this medication is suitable and safe to use in children.

Quviviq is a federally-controlled substance that is federally controlled (Schedule Pending) because it could be misused and result in dependence.

Make sure to keep Quviviq in a secure location to protect it from misuse and misuse. Giving away or selling this medication can cause harm to other people and is against the law.

Description

QUVIVIQ contains daridorexant, an orexin receptor antagonist. The chemical name of daridorexant hydrochloride is (S)-(2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone hydrochloride. The molecular formula is C23H23N6O2Cl * HCl. The molecular weight is 487.38 g/mol.

Quviviq (Daridorexant )

Daridorexant hydrochloride is a white to light yellowish powder that is very slightly soluble in water.

QUVIVIQ tablets are intended for oral administration. Each film-coated tablet contains 27 mg or 54 mg of daridorexant hydrochloride equivalent to 25 mg or 50 mg of daridorexant, respectively. The inactive ingredients are croscarmellose sodium, magnesium stearate, mannitol, microcrystalline cellulose, povidone, and silicon dioxide.

In addition, the film coating contains the following inactive ingredients: glycerin, hypromellose, iron oxide black, iron oxide red, microcrystalline cellulose, talc, titanium dioxide, and, in the 50 mg tablet only, iron oxide yellow.

Mechanism of Action

Daridorexant

The mechanism of action of daridorexant in the treatment of insomnia is presumed to be through antagonism of orexin receptors. The orexin neuropeptide signaling system plays a role in wakefulness. Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive.

Important information

Quviviq may cause serious side effects, including:

Read about Qviviq’s side adverse effects for more details about the side effects.

Warnings and Precautions

Who shouldn’t take Quviviq?

Avoid taking this medication when you sleep frequently at unplanned moments (narcolepsy).

Before taking Quviviq

Before taking this medication tell your physician about your medical issues, including the following:

What other drugs can have an effect on Quviviq?

Inform your doctor about every medicine you are taking such as prescription and over-the-counter medications such as vitamins, herbal supplements.

When you take this medication along with certain medications can cause serious adverse side adverse effects. this medication could affect the way other medications work, and different medications could affect how this medication functions.

Take care not to take this medication alongside other medications which can cause you to sleep unless your physician advises you to.

Other medications can influence this medication. Other medications can affect Quviviq, including prescription and non-prescription medicines as well as vitamins and herbal products. Inform your doctor about the medicines you are currently taking as well as any medications you are about to start or stop taking.

What is the best way to do it? Quviviq?

Dosing and administration

Recommended Dosage

The recommended dosage range is 25 mg to 50 mg of QUVIVIQ taken orally no more than once per night within 30 minutes of going to bed (with at least 7 hours remaining prior to planned awakening).

Time to sleep onset may be delayed if taken with or soon after a meal 

Dosage Recommendations for Concomitant Use with CYP3A4 Inhibitors or CYP3A4 Inducers

Dosage Recommendations for Patients with Hepatic Impairment

The maximum recommended dosage in patients with moderate hepatic impairment (Child-Pugh score  7–9) is 25 mg of QUVIVIQ no more than once per night

QUVIVIQ is not recommended in patients with severe hepatic impairment (Child-Pugh score ≥ 10)

Dosage and strength

QUVIVIQ (daridorexant) tablets are available as:

What should I stay clear of while taking Quviviq?

Quviviq side effects

Quviviq may cause serious side effects, including:

The most commonly reported adverse effects are headaches and insomnia.

This is not the only list of the possible adverse consequences. Contact your doctor for advice regarding medical possible side effects. You can report any side effects to the FDA via 800-FDA-1088.

How do I store Quviviq?

General information on the safety of Quviviq.

Sometimes, medicines are used for reasons other than the ones listed in the Medication Guide. Use this medicine only for any medical condition for which it is not recommended. Don’t give it to others even if they suffer from similar symptoms as you do. It may cause harm to them. It is possible to seek advice from your doctor or pharmacist for advice specifically written specifically for healthcare professionals.

What are the ingredients of Quviviq?

Active ingredient: daridorexant hydrochloride
Inactive ingredients include croscarmellose sodium magnesium stearate, mannitol povidone, microcrystalline cellulose as well as silicon dioxide.
Its film is made up of the following components: glycerin, hypromellose iron oxide black and red iron oxide, microcrystalline cellulose, talc titanium dioxide, and in the tablet of 50 mg only the color of iron oxide are yellow.

More details

Always consult your doctor to confirm that the information provided on this site is appropriate to your particular situation.

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