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Name of the generic: apremilast
Name of the brand: Otezla
Classification of drugs: Antirheumatics


What is Otezla?


Otezla (apremilast) is an apremilast inhibitor that blocks an immune system, which can impact specific cells and lead to inflammation throughout the body.

it thelps reat active psoriatic arthritis that is present in adults.

Otezla can also be used for treating mild and severe plaque psoriasis in adults. They may also be treated with phototherapy or other treatments for psoriasis.

Otezla can also be utilized to heal mouth ulcers in people suffering from Behcet’s disease (a disease that causes inflammation of blood vessels).



When you take Otezla Your weight needs to be regularly monitored. Any unprovoked or significant weight loss must be disclosed to your doctor.

Consult your physician for assistance if you suffer from extreme nausea, diarrhea or vomiting.

There are people who think about suicide when taking Otezla. Be aware of any changes to your mood, or signs. Be sure to report any new or worsening symptoms to your physician.


Before you start taking this medicine, make sure to consult your doctor

It is recommended not to take Otezla in case you have an allergy to the ingredient apremilast.

To ensure that Otezla is safe for you, inform your doctor if you’ve previously experienced:

  • kidney disease or
  • suicidal or depression-related thoughts or behaviors.

Many people are contemplating suicide when taking Otezla. Your doctor must examine your progress every few check-ups. Your family members and other caregivers should be aware of changes in your mood or the symptoms.

Apremilast could harm a newborn baby. Use effective birth control methods to avoid pregnancy and inform your physician if you are pregnant.

If you’re expecting then your name might be included on an ob-gyn registry to monitor how apremilast affects the baby.

It might not be safe to breastfeed while taking this medication. Consult your physician about any potential risks.

Otezla is not permitted for use by anyone less than 18 years old.


How should I take Otezla?

Use Otezla exactly as directed by your physician. Follow the instructions on your prescription label, and review all medication guides and instructions. The doctor might change the dosage of your medication.

You can take Otezla either with or without meals.

Suck the tablet completely and don’t crush, chew or break it.

Maintain a tracker of your body’s weight as you take this medication and inform your doctor of any significant weight loss.

Keep at room temperature, free of heat and moisture.


Dosing information

Usual Adult Dose for Psoriatic Arthritis:

Initial dose:
Day 1:10 mg taken orally at least once per day (AM)
Day 2, 10 mg taken orally every day, twice (AM as well as PM)
Day 3, 10 mg orally twice per day (AM) 20 mg orally every day (PM)
Day 4 20 mg taken orally every day, twice (AM as well as PM)
Day 5 20 mg orally twice every day (AM) 30 mg once orally per day (PM)

Maintenance dosage: 30 mg taken orally, twice daily (AM as well as PM)

Comment: The titration procedure is meant to alleviate the digestive symptoms of the first-time treatment.

Use: Treatment for adult patients suffering from active Psoriatic Arthritis


How do I deal with it if do not take the dose?

You should take the medication as quickly as you can, however, avoid your missed dosage if you are nearing the time to take the next dose. Don’t have two doses at one time.


If I take too much?

For medical emergencies, seek emergency medical attention or contact toll-free the Poison Help line at 1-800-222-1222.


What to avoid

Follow the instructions of your physician regarding any restrictions on your food, drink or any activity.


Otezla side effects

Take immediate medical attention If you are experiencing indications that indicate an allergy reaction Otezla: hives; difficulty breathing or swelling of your lips, face tongue, throat, or face.

Contact your doctor immediately If you suffer from:

  • severe nausea, diarrhea, and vomiting, chest pain
  • Unexplained weight loss, or if you shed significant weight
  • mood shifts mood changes, new or worsening depression mood changes, new or worsening depression
  • the thoughts of suicide or harming yourself.

Common Otezla side effects can be:

  • nausea, diarrhea;
  • headaches or
  • cold symptoms like nasal stuffiness, sneezing, sore throat.

This is not a comprehensive list of all side effects. others could happen. Contact your doctor for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


What other medications can impact Otezla?

It is sometimes not safe to use certain medicines in conjunction. Certain drugs may affect the blood levels and levels of other drugs that you are taking. This could cause more side effects or make the medication less effective.

Other drugs can be incompatible with apremilast, such as prescription and over-the counter medicines as well as vitamins and herbal products. Discuss with your physician the medicines you are currently taking as well as any medications you are about to start or stop taking.

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