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Generic name: cyclobenzaprine
The class of drug: Skeletal muscle relaxants


Brand names

In the U.S.

  • Amrix
  • Fexmid
  • Flexeril
  • FusePaq Tabradol

Available Dosage Forms:

  • Capsule, Extended Release
  • Tablet
  • Suspension

Therapeutic Class: Skeletal Muscle Relaxant, Centrally Acting

Uses for cyclobenzaprine

Cyclobenzaprine helps to relax specific muscles within your body. It can ease stiffness, pain, and discomfort that is caused by strains, strains, and injuries that your muscles suffer. However, it does not substitute for rest, physical therapy, or any other treatment your doctor might suggest for your medical issue. Cyclobenzaprine is a stimulant for the central nervous system (CNS) to create its effects on muscles that relax. This action on CNS can also trigger some of the side effects associated with cyclobenzaprine.

Cyclobenzaprine is only available with the prescription of your physician.

Before using cyclobenzaprine

When deciding whether to take any medicine, the dangers of using the drug should be evaluated against the positive effects it could bring. This is a choice that both you and your physician will take. For cyclobenzaprine, these are to be considered


Inform your doctor whether you’ve had an unusual reaction or allergy to cyclobenzaprine, or any other medications. Inform your health care doctor if you are suffering from other allergies, for example, to dyes, foods preservatives, animals, or dyes. For products that are not prescription-only, you must review the label or the ingredient list carefully.


Studies that are appropriate have not been conducted on the relation of age and the effects of cyclobenzaprine extended release capsules in the infant population. The safety and effectiveness of the product have not been confirmed.


Due to the possibility of increased blood levels in the elderly when compared with younger adults, taking extended-release cyclobenzaprine capsules isn’t advised for the older.


There aren’t enough studies of women that can determine the risk to infants when taking this medication while breastfeeding. Consider the benefits and the risks that could be associated with taking this medication when nursing.

Interactions between medicines

While certain medications should not be taken together In other instances, two medicines could be taken together, even though interactions could occur. In these situations, your doctor might decide to alter the dosage or take other precautions if needed. If you’re taking cyclobenzaprine it is crucial that you let your doctor know that they prescribe any one of these drugs mentioned below. These interactions have been determined based on their potential importance and are not all-inclusive.

Utilizing cyclobenzaprine in conjunction together with any of these medications is not advised. Your physician may choose not to prescribe this drug or modify any other medication you are taking.

  • Bepridil
  • Cisapride
  • Dronedarone
  • Furazolidone
  • Iproniazid
  • Isocarboxazid
  • Levomethadyl
  • Linezolid
  • Mesoridazine
  • Methylene Blue
  • Moclobemide
  • Pargyline
  • Phenelzine
  • Pimozide
  • Piperaquine
  • Procarbazine
  • Rasagiline
  • Safinamide
  • Saquinavir
  • Selegiline
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Tranylcypromine
  • Ziprasidone

Combining cyclobenzaprine with one of the listed medicines is not usually recommended however it may be necessary in certain situations. If two medicines are prescribed and your doctor recommends a change in the dosage or the frequency at which you take one or both of the drugs.

  • Alfentanil
  • Almotriptan
  • Alprazolam
  • Amineptine
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Amphetamine
  • Anagrelide
  • Apomorphine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Balofloxacin
  • Bedaquiline
  • Benzhydrocodone
  • Benzphetamine
  • Besifloxacin
  • Bromazepam
  • Buprenorphine
  • Buserelin
  • Butriptyline
  • Calcium Oxybate
  • Cannabidiol
  • Ceritinib
  • Cetirizine
  • Chloroquine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Clofazimine
  • Clomipramine
  • Clozapine
  • Codeine
  • Crizotinib
  • Dabrafenib
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dextroamphetamine
  • Dibenzepin
  • Dihydrocodeine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Dothiepin
  • Doxepin
  • Doxylamine
  • Droperidol
  • Duloxetine
  • Efavirenz
  • Encorafenib
  • Enoxacin
  • Entrectinib
  • Erythromycin
  • Escitalopram
  • Esketamine
  • Fenfluramine
  • Fentanyl
  • Fexinidazole
  • Fingolimod
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Flumequine
  • Fluoxetine
  • Fluvoxamine
  • Formoterol
  • Foscarnet
  • Fostemsavir
  • Gabapentin
  • Gabapentin Enacarbil
  • Gatifloxacin
  • Gemifloxacin
  • Glasdegib
  • Glucagon
  • Glycopyrrolate
  • Glycopyrronium Tosylate
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Histrelin
  • Hydrocodone
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxytryptophan
  • Hydroxyzine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Inotuzumab Ozogamicin
  • Iprindole
  • Ivabradine
  • Ivosidenib
  • Ketamine
  • Ketoconazole
  • Lapatinib
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Levocetirizine
  • Levofloxacin
  • Levomilnacipran
  • Levorphanol
  • Lisdexamfetamine
  • Lithium
  • Lofepramine
  • Lofexidine
  • Lomefloxacin
  • Lorcaserin
  • Loxapine
  • Lumefantrine
  • Macimorelin
  • Magnesium Oxybate
  • Melitracen
  • Meperidine
  • Metaxalone
  • Methacholine
  • Methadone
  • Methamphetamine
  • Metoclopramide
  • Metronidazole
  • Midazolam
  • Milnacipran
  • Mirtazapine
  • Mobocertinib
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nadifloxacin
  • Nafarelin
  • Nefazodone
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Ofloxacin
  • Ondansetron
  • Opipramol
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paliperidone
  • Palonosetron
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pazufloxacin
  • Pefloxacin
  • Periciazine
  • Pimavanserin
  • Pitolisant
  • Pixantrone
  • Ponesimod
  • Posaconazole
  • Potassium Oxybate
  • Pregabalin
  • Propizepine
  • Protriptyline
  • Prulifloxacin
  • Quetiapine
  • Quinidine
  • Ranolazine
  • Remifentanil
  • Remimazolam
  • Revefenacin
  • Ribociclib
  • Ropeginterferon Alfa-2b-njft
  • Rufloxacin
  • Scopolamine
  • Secretin Human
  • Selpercatinib
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Siponimod
  • Sodium Oxybate
  • Sodium Phosphate
  • Solifenacin
  • Sotalol
  • Sufentanil
  • Sulpiride
  • Sunitinib
  • Tacrolimus
  • Tapentadol
  • Telithromycin
  • Tetrabenazine
  • Tianeptine
  • Tiotropium
  • Tramadol
  • Trazodone
  • Triclabendazole
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Vortioxetine
  • Zolpidem
  • Zuclopenthixol

Interactions with alcohol, tobacco, or food

Certain medications shouldn’t be used during or in conjunction with having food items or eating particular kinds of food as interactions could happen. The use of tobacco or alcohol together with certain medications can result in interactions. The following interactions have been chosen because of their potential importance and are not intended to be comprehensive.

Combining cyclobenzaprine with one of the following substances is typically not advised, but it could be necessary in certain situations. If you take them together with other medications, your doctor could alter the dosage or frequency you take cyclobenzaprine or give you specific directions regarding the consumption of food and alcohol or tobacco.

  • Tobacco

Other medical issues

The presence of any other medical conditions can affect the dosage of Cyclobenzaprine. Be sure to inform your doctor if there are any other medical issues including:

  • Congestive heart failure 
  • Heart attack
  • Heart blockage 
  • Heart rhythm problems (eg, arrhythmia
  • The condition of hyperthyroidism (overactive thyroid)–Should not be treated for patients suffering from these disorders.
  • Glaucoma and angle-closure background of 
  • Urinary problems, history of–Use with cautiousness. These conditions could become worse.
  • Liver disease – Use with cautiousness. The effect may be heightened due to the slow removal of the medication in the human body.

Use of the drug in the right way cyclobenzaprine

Use cyclobenzaprine only when recommended by your doctor. Don’t take too much of it, and do not use it more frequently than what your doctor has prescribed. This could increase the chance of severe adverse reactions.

Consume the extended-release capsule completely. If you are unable to take the capsule in its entirety it is possible to break the capsule open and spread the contents onto 1 tablespoon applesauce. Take the mixture in one go without chewing. Rinse your mouth thoroughly to ensure all the medicine has been swallowed. Do not keep any of the mixes to use later on.


The dosage of cyclobenzaprine may differ for different patients. Follow the doctor’s instructions or the instructions printed on your prescription. The information below is only the most common dose of cyclobenzaprine. If you have a different dose don’t alter it unless your physician tells you to change it.

The amount of medicine you are taking is determined by your strength drug. In addition, the number of doses that you are taking each day, the interval between doses, and the amount of time you use the medication are contingent on the medical issue that you’re treating using the medication.

  • For easing stiff muscles:
    • For oral dosage forms (extended-release capsules):
      • Adults – 15 milligrams (mg) daily. Some patients might require thirty milligrams (one thirty mg capsule and two capsules of 15 mg) daily.
      • Children–Use and dosage should be approved by your physician.
    • For oral dosage form (tablets):
      • Adults and children aged 15 years old and over–10 milligrams (mg) three times every day. The maximum quantity should be less than 60 milligrams (six tablets of 10 mg) every day.
      • Children under 15 years old – Use and dosage must be determined by your physician.

Missed dose

If you have missed the dose of cyclobenzaprine do it as quickly as you can. But, if it’s close to the time for the next dose, you can skip any missed doses and then return to your normal dosing schedule. Don’t double doses.


Place the medication in a sealed bottle at room temperatures, and away from moisture, heat, and sunlight. Be sure to keep the medicine from getting frozen.

Keep away from the reach of children.

Avoid keeping outdated medicines or medicines that are no longer required.

Consult your physician about what you can do with any medicine that you do not take.

Detailed Cyclobenzaprine dosage information

Use caution when using cyclobenzaprine.

It is vital to have your doctor review your progress every time you visit. This will allow your doctor to determine whether your medication is functioning well and decide whether or not you should take the medication.

If your health condition does not improve within two or three weeks, or if the condition gets worse, consult your physician.

Do not take extended-release pills when you’ve previously taken one of the MAO inhibitors (MAOI) like Eldepryl(r), Marplan(r), Nardil(r), or Parnate(r) within 14 days of one another.

Talk to your doctor now if you are experiencing anxiousness, constant restlessness rapid heartbeat, fever muscles spasms, sweating and twitching, nausea diarrhea, vomiting, or even hearing or seeing things that you don’t see or hear. These are signs of a more serious disease called serotonin syndrome. The risk is higher in the event that you take other medications that impact the levels of serotonin in your body.

Cyclobenzaprine is a compound that can increase the effect of alcohol as well as various CNS depressants (medicines that reduce your nervous system potentially creating sleepiness). A few examples of CNS depressants include antihistamines, remedies for hay fever, allergies or colds tranquilizers, sedatives or sleeping pills prescription pain medication or medications for seizures or barbiturates various muscle relaxants, and anesthetics that include certain dental anesthetics. Talk to your doctor prior to taking any of the listed when you’re taking Cyclobenzaprine.

Cyclobenzaprine can cause people to experience blurred vision, or become drowsy, and less alert than they normally are. Be aware of the reaction you will experience to cyclobenzaprine prior to driving, using machines, or performing any other activity that is risky in the event that you’re unsteady or dizzy and able to focus.

Cyclobenzaprine can cause dryness in the mouth. For temporary relief, try gum or candy that is sugar-free and melt pieces of ice inside your mouth. You can also try saliva replacement. If your mouth feels dry for longer than two weeks, you should consult with your dentist or doctor. A dry mouth for a long time can increase the likelihood of developing dental diseases, such as gum disease, tooth decay, and fungus-related infections.

Cyclobenzaprine side effects

Alongside its necessary effects, some medicines may produce unwanted side adverse effects. While not all of these adverse effects can occur, if they occur, they might require medical attention.

Consult your physician immediately If any of these adverse effects happen:


  • Unsteadiness or clumsiness
  • confusion
  • fainting
  • mental depression
  • Problems with urination
  • The buzz or ringing of the ears
  • itching, hives, or itching, which are not signs that suggest an allergic reaction as described above
  • bizarre thoughts or visions
  • Yellow eyes or skin

Contact emergency assistance immediately in the event that any of these signs of an overdose develop:

Signs of an overdose

  • Convulsions (seizures)
  • Drowsiness (severe)
  • dry, hot, and flushed skin
  • rapid or irregular heartbeat
  • hallucinations (seeing hearing, seeing, or experiencing things that aren’t in the real world)
  • change or decrease in the body temperature
  • Troubled breathing
  • Unknown cause of muscular stiffness
  • Atypical anxiousness or unrest (severe)
  • vomiting (occurring in conjunction with other signs of an overdose)

There are some side effects that can occur that usually don’t require medical care. These symptoms may disappear after treatment, as your body adjusts the medication. Additionally, your doctor might be able to inform you of ways to avoid or minimize certain adverse effects. Talk to your doctor for any of these adverse effects that persist or are troubling or if you have concerns about these:

More popular

  • Vision blurred
  • dizziness, drowsiness, lightheadedness
  • Dryness in the mouth

More rare or uncommon

  • Gas or bloated feeling nausea, indigestion, nausea, vomiting, stomach cramps or discomfort
  • constipation
  • diarrhea
  • Nervousness or excitement
  • frequent urination
  • a general feeling of discomfort or sickness
  • headache
  • muscles moving
  • Tingling, numbness, or weakening of the hands or feet
  • pounding heartbeat
  • difficulties in speaking
  • Tense
  • difficulty sleep
  • unpleasant taste, or any other modifications
  • Muscle weakness that is unusual
  • Unusual fatigue

Other adverse side effects that are not listed could also be present in certain patients. If you observe any other symptoms, consult with your doctor.

Consult your physician for advice from a medical professional regarding possible side effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.

Cyclobenzaprine side effects (more detail)

More details

Always consult your physician to make sure the information presented on this page is applicable to your specific situation.

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