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Name of the generic: mesalamine 
The brand name is: Apriso
Class of drugs: 5-aminosalicylates


What is Apriso?


Apriso (mesalamine) affects a substance within the body that triggers tissue damage, inflammation and diarrhea.

Apriso is a treatment for moderate to mild ulcerative colitis in patients aged 18 years old and over.

This medication used to stop those symptoms associated with ulcerative colitis from returning.


Stop taking Apriso and contact your doctor immediately if you experience extreme gastric pain, stomach cramps and red diarrhoea (may be accompanied by the appearance of fever migraine or skin eruptions).

Before taking this medication, you must consult your physician

It is recommended not to take Apriso in the event that you are allergic to mesalamineor aspirin and salicylates, such as sulfasalazine or (such like Disalcid, Doans Pills, Dolobid Kaopectate Nuprin backache Pepto-Bismol, Tricosal, Trilisate and more).

To be sure Apriso is suitable for you, ask your physician if you’ve ever experienced:

  • a kidney stone , or kidney disease
  • Liver disease;
  • A blockage in your stomach or in your intestines (such as pyloric theosis) or
  • a skin condition such as eczema.

The capsules in Apriso contain the chemical phenylalanine. Consult your physician if you are suffering from the condition known as phenylketonuria (PKU).

Consult your physician if are pregnant or planning to be pregnant. It isn’t known if mesalamine can cause harm to a newborn baby. If untreated, or uncontrolled ulcerative bowel colitis during pregnancy can result in complications , such as the low birth weight or premature birth. The benefits in treating the ulcerative colitis could outweigh the risks for the infant.

It might not be safe to breastfeed during this medication. Talk to your doctor about any risks. If you’re nursing, inform your doctor if there is diarrhea in your nursing infant.

Don’t give this medication to children. Apriso is not permitted for use by any person younger than 18 years old. of age.

How to take Apriso?

You should take Apriso exactly as directed by your physician. Follow the directions on the prescription label and study all medication guides or instructions sheets.

This medication can alter the results of certain tests. Inform any physician who treats you that you’re taking mesalamine.

You can consume Apriso either with food or no.

Drink plenty of fluids to prevent kidney stones..

Take the capsule in its entirety and don’t open, chew or tear it. Inform your physician when you’re having trouble taking your capsule.

Contact your doctor if ulcerative colitis symptoms don’t improve or become worse.

This medicine may affect the outcomes of certain medical tests. Inform any physician who is treating patients that you’re using Apriso.

It is possible that you will require regular blood tests to test your kidney or blood cell function.

Keep at room temperature, far from heat and moisture.

Dosing information

Usual Adult Dose for Ulcerative Colitis 

Apriso Extended release capsules 375 mg: 1.5 g (4 capsules) daily, orally in the morning

Do not take Apriso 375 mg extended-release capsules with anti-acids.

Use for maintenance of remission ulcerative colitis for adults.

What if I miss the dose?

You should take the medication as quickly as you are able, but do not take your missed dosage if it’s nearing the time to take the next dose. Don’t have two doses in one time.

If I take too much?

Get medical attention immediately or contact for help at the Poison Help line at 1-800-222-1222.

What should I be aware of when taking Apriso?

If you suffer from an issue with your skin, such as eczema or eczema-like skin, mes your skin more susceptible to sunburn. Avoid tanning beds or sunlight. Be sure to wear protective attire and apply sunblock (SPF 30 or more) while you’re outdoors.

Consult your physician before taking an antacid. Make sure you use only the kind recommended by your physician. Certain Antacids could make it more difficult for your body to absorb mesalamine.

Apriso side effects

See a doctor immediately If you are experiencing symptoms that indicate an allergy reaction with Apriso such as Hives and breathing problems or swelling of your lips, face and throat.

Stop taking Apriso and contact your doctor immediately if you suffer from:

  • severe stomach pain, stomach cramping, bloody diarrhea;
  • headache, fever general feeling of ill-health, chest pain;
  • Itching, rash, eyes redness;
  • The stool is bloody or tarry, coughing up blood or vomit that appears like coffee grounds
  • lower white blood cell count such as chills, fever and mouth sores. Skin ulcers irritation of the throat and cough. Feeling lightheaded, breathing problems;
  • indications of a kidney stone The most severe pain is felt in your back and sides frequently having to urinate in a foul-smelling, foul-smelling clear or dark urine;
  • kidney issues Increased or decreased urination and weight gain.
  • liver issues loss of appetite, stomach pain, tiredness bleeding or bruising that is easy to stop and dark urine, clay-colored stool, jaundice (yellowing of the eyes or skin).

The low white blood cell count could be more prevalent for older adults.

Common side effects from Apriso include:

  • burping, constipationnauseavomiting, stomach pain, diarrhea, gas;
  • dizziness;
  • symptoms of cold like nasal stuffiness, sneezing, sore throats;
  • lower back pain;
  • headache;
  • It can be a rash or
  • An abnormality in tests for liver function.

This is not a comprehensive list of possible side effects, and other side effects could be present. Contact your physician for advice regarding medical adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.


What other medications can impact Apriso?

Apriso may affect your kidneys, specifically when you are also taking certain medications to treat osteoporosis, cancer, infections rejection of organ transplants, digestive issues and high blood pressure or arthritis pain (including Advil, Motrin, and Aleve).

Discuss with your doctor all other medicines you take particularly:

  • azathioprine or 6-mercaptopurine.

This list isn’t comprehensive. Other drugs can be incompatible with mesalamine, such as medications that are prescribed and available over the counter, vitamins, and herbal products.

Additional details

Keep this and other medications away from reach of children. Never give your medication to anyone else and make sure you take Apriso only in the manner given.

Always consult your physician to make sure the information presented on this site is appropriate to your particular situation.

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