ANDROXY SIDE EFFECTS

Last updated on MDtodate: 10/6/2022

SIDE EFFECTS

Endocrine And Urogenital

Female

The most common side effects of androgen therapy are amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement. The latter usually is not reversible after androgens are discontinued. When administered to a pregnant woman, androgens cause virilization of external genitalia of the female fetus.

Male

Gynecomastia, and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.

Skin and Appendages – Hirsutism, male pattern baldness, and acne.

Fluid and Electrolyte Disturbances – Retention of sodium, chloride, water, potassium, calcium and inorganic phosphates.

GastrointestinalNausea, cholestatic jaundice, alterations in liver function tests; rarely, hepatocellular neoplasms, peliosis hepatis, hepatic coma, and death.

Hematologic – Suppression of clotting factors II, V, VII, and X; bleeding in patients on concomitant anticoagulant therapy; and polycythemia.

Nervous System – Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.

Metabolic – Increased serum cholesterol.

Miscellaneous – Hypersensitivity; rarely, anaphylactoid reactions.

 

SRC: NLM .