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Generic name: ursodiol
Brand name: Actigall
Dosage forms: oral capsule (200 mg; 300 mg; 400 mg); oral tablet (250 mg; 500 mg)
Drug class: Gallstone solubilizing agents

What is Actigall?

Actigall is used to dissolve tiny gallstones that are too small to be removed surgically, as well as to prevent gallstones from forming during periods of fast weight loss. Actigall will not dissolve gallstones that have become hardened.

Ursodiol 300 mg capsule

Actigall is used to treat primary biliary cirrhosis, which is caused by an autoimmune condition that causes the gradual deterioration of the bile ducts in your liver. Actigall pills are taken orally.

The medicine Actigall may potentially be used for other conditions that are not covered in this pharmaceutical guide.

Warnings and Precautions

Use only as advised by the manufacturer. Inform your doctor if you are taking any other medications or if you have any medical issues or allergies.

Prior to using this medication, you should consult your doctor

If you are allergic to Actigall or if you have a blockage in your liver or gallbladder, you should avoid using it. Inform your doctor if you experience any of the following symptoms:

Alternatively, you have been coughing up blood;

You have acquired a significant amount of weight, particularly around your face and belly.

Inform your doctor if you are expecting a child or if you are nursing.

Anyone under the age of eighteen is not permitted to use this product.

What is the best way to take Actigall?


Follow all of the recommendations on your prescription label and be sure to read any medication guides or instruction sheets that come with your medicine. Follow the directions on the prescription label.

The Actigall pill should be taken with meals.

It is possible that you will need to break a pill in half to acquire the right dose.

Each tablet fragment should be swallowed whole with a glass of water. It is possible that a broken pill will have a bitter flavor.

Following the breaking of a tablet, store it separately from the rest of the tablets and utilize it within 28 days of the breakage.

To achieve the optimum outcomes, use Actigall on a daily basis.

Doses are calculated depending on body weight. If you gain or lose weight, your dosage may need to be adjusted.

Medical diagnostics, such as gallbladder ultrasound checks and blood tests to assess your liver function, may be required in your situation. Additionally, you may require liver function tests every 6 months after stopping the use of Actigall.

If your symptoms do not improve or if they worsen, you should consult your doctor.

Actigall is a medication that can be used for several months to cure gallstones. Some gallstones may not entirely dissolve, and you may develop new gallstones within 5 years after having your gallstones removed. Inquire with your doctor about your particular risk.

Keep firmly closed at room temperature, away from moisture and heat, and out of reach of children.

What happens if I don’t take my medication on time?

Take the medication as soon as you are able, but if it is almost time for your next dosage, omit the missed dose and continue with your regular schedule. Do not take more than one dosage at a time.

Take action before you run out of medication entirely.

What happens if I take too much?

Seek immediate medical treatment or dial 1-800-222-1222 to reach the Poison Help hotline for assistance.

What to avoid while taking Actigall

Before using an antacid, consult your doctor, and only use the type of antacid that he or she advises.

Actigall side effects

If you have any of the following symptoms of an allergic reaction: hives, difficulty breathing, chest pain swelling of your face, lips, tongue, or throat, get emergency medical attention.

If you develop any of the following symptoms, call your doctor right away:

You may have discomfort or burning during urinating.

Symptoms of liver disease include nausea, upper stomach discomfort, itching, fatigue, lack of appetite, dark urine, clay-colored feces, jaundice (yellowing of the skin or eyes); or a combination of these symptoms.

New infection symptoms include abrupt weakness or sick feeling, high fever, chills, a painful throat, mouth sores, skin sores, and difficulties swallowing.

The following are examples of common side effects:

Irritation of the stomach, nausea, and vomiting;

Irritation, diarrhea, constipation;

coughing and painful throat

urinating that is excruciating;

hair thinning, or Back discomfort is a common complaint.

The following is not a comprehensive list of possible side effects, and more may occur. For medical advice concerning side effects, consult with your doctor. You can report adverse effects to the Food and Drug Administration at 1-800-FDA-1088.

Dosing instructions for Actigall

The typical adult dose for biliary cirrhosis is as follows:

To be taken orally once a day in two to four split doses with meals, 13 to 15 mg/kg per day in tablet form.

Observations: -The dose should be tailored to the individual patient’s need.
If necessary, scored pills can be split in half to deliver the prescribed dosages.

Patients with primary biliary cirrhosis are treated with this medication (PBC)

The typical adult dose for gallbladder disease is as follows:

Gallstone dissolving with capsules: 8 to 10 mg/kg orally every day, given in 2 to 3 divided doses, administered in 2 to 3 divided doses

The recommended dose for gallstone prevention is 300 mg taken orally twice a day with a maximum daily intake of 600 mg.

Observations: -The safety of this medicine in the dissolving of gallstones has not been demonstrated in patients who have used it for more than 24 months.
In the first year of treatment, ultrasound pictures should be acquired every six months.
The therapy should be continued if the gallstones appear to be dissolving; the dissolution should be verified by ultrasound after 1 to 3 months if the gallstones have not disintegrated.
-At the initial on-treatment reevaluation, the majority of patients who achieve total dissolution demonstrate partial or complete dissolution.
In the event that just partial stone breakdown is detected after 12 months of therapy, the chance of undergoing further treatment is greatly decreased.

Patients with radiolucent, noncalcified gallbladder stones less than 20 mm in greatest diameter who would otherwise undergo elective cholecystectomy if not for the presence of increased surgical risk due to advanced age, idiosyncratic reaction to general anesthesia, systemic disease, or those who refuse surgery are candidates for this procedure.
Preventing gallstone development in obese people who are losing weight rapidly is the goal of this medication.

What additional medications will have an effect on Actigall?

If you use certain cholesterol-lowering medications, such as the following, it may be more difficult for your body to absorb Actigall.

cholestyramine; alternatively


Include all additional medications you are taking, including birth control pills and estrogen-containing products.

Other medications, including prescription and over-the-counter medications, vitamins, and herbal supplements, may have an adverse effect onActigall. Some medication interactions are not included here because they are not all feasible.

Actigall Label



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