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Xeljanz Dosage

Generic name: tofacitinib
Brand names: Xeljanz, Xeljanz XR
Drug class: Antirheumatics

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  TAB: 5 mg, 10 mg; SOL: 1 mg per mL

Special Note

[formulation clarification]
Info: solution not interchangeable w/ ER product; do not substitute on a mg per mg basis

Rheumatoid arthritis, mod-severe

[5 mg PO bid]
Info: see pkg insert for toxicity-related dose adjustments

Psoriatic arthritis

[5 mg PO bid]
Info: use w/ non-biologic DMARDs; see pkg insert for toxicity-related dose adjustments

Ankylosing spondylitis

[5 mg PO bid]
Info: see pkg insert for toxicity-related dose adjustments

Ulcerative colitis, mod-severe

[5 mg PO bid]
Start: 10 mg PO bid for at least 8wk, then 5 mg PO bid; Info: use lowest effective dose, shortest effective tx duration; may cont. 10 mg PO bid for up to 16wk total if initial response lost; D/C if no benefit at 10 mg PO bid x16wk; see pkg insert for toxicity-related dose adjustments

Renal dosing

[if usual dose 5 mg bid]
moderate-severe impairment: 5 mg qd
HD: 5 mg qd, on dialysis days admin. after dialysis; no supplement; PD: not defined
[if usual dose 10 mg bid]
moderate-severe impairment: 5 mg bid
HD: 5 mg bid, on dialysis days admin. after dialysis; no supplement; PD: not defined

Hepatic dosing

[if usual dose 5 mg bid]
moderate impairment: 5 mg qd; severe impairment: avoid use
[if usual dose 10 mg bid]
moderate impairment: 5 mg bid; severe impairment: avoid use

 

SRC: NLM .

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