Tivicay Dosage

Generic name: dolutegravir
Brand names: Tivicay, Tivicay PD
Drug class: Integrase strand transfer inhibitor

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 10 mg, 25 mg, 50 mg

Special Note

[formulation clarification]

Info: not interchangeable w/ dolutegravir dispersable tabs; do not substitute on a mg to mg basis

HIV infection

[tx-naive or tx-experienced INSTI-naive pts]

Dose: 50 mg PO qd; Info: incr. dose to 50 mg PO bid if also receiving carbamazepine, efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin; see pkg insert for two-drug rilpivirine combo

[INSTI-experienced pts w/ INSTI resistance]

Dose: 50 mg PO bid; Info: for pts w/ certain INSTI-assoc. resistance substitutions or clinically suspected INSTI resistance

HIV post-exposure prophylaxis, nonoccupational

[50 mg PO qd x28 days]

Info: incr. dose to 50 mg PO bid if also receiving carbamazepine, efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin; part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table

Renal dosing

[tx-naive or tx-experienced INSTI-naive pts]

renal impairment: no adjustment

HD/PD: not defined

[INSTI-experienced pts w/ INSTI resistance]

mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised

HD/PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

SRC: NLM .