TIMENTIN SIDE EFFECTS
- Generic Name: ticarcillin and clavulanate
- Brand Name: Timentin
- Drug Class: Penicillins, Extended-Spectrum
As with other penicillins, the following adverse reactions may occur:
Skin rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills, chest discomfort, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, and anaphylactic reactions.
Central Nervous System
Headache, giddiness, neuromuscular hyperirritability, or convulsive seizures.
Disturbances of taste and smell, stomatitis, flatulence, nausea, vomiting and diarrhea, epigastric pain, and pseudomembranous colitis have been reported. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment.
Hemic and Lymphatic Systems
Thrombocytopenia, leukopenia, neutropenia, eosinophilia, reduction of hemoglobin or hematocrit, and prolongation of prothrombin time and bleeding time.
Abnormalities of Hepatic Function Tests
Elevation of serum aspartate aminotransferase (SGOT), serum alanine aminotransferase (SGPT), serum alkaline phosphatase, serum LDH, serum bilirubin. There have been reports of transient hepatitis and cholestatic jaundice—as with some other penicillins and some cephalosporins.
Renal and Urinary Effects
Hemorrhagic cystitis, elevation of serum creatinine and/or BUN, hypernatremia, reduction in serum potassium, and uric acid.
Pain, burning, swelling, and induration at the injection site and thrombophlebitis with intravenous administration.
Available safety data for pediatric patients treated with TIMENTIN demonstrate a similar adverse event profile to that observed in adult patients.
Drug Abuse And Dependence
Neither abuse of nor dependence on TIMENTIN has been reported.
SRC: NLM .