Generic name: atenolol and chlorthalidone
Brand names: Tenoretic 100, Tenoretic 50
Drug class: Beta blockers with thiazides
Medically reviewed by A Ras MD
What is Tenoretic used for?
Tenoretic is a prescription medicine that is used to treat high blood pressure.
TENORETIC® (atenolol and chlorthalidone) is for the treatment of hypertension. It combines the antihypertensive activity of two agents: a beta1-selective (cardioselective) hydrophilic blocking agent (atenolol, TENORMIN®) and a monosulfonamyl diuretic (chlorthalidone). Atenolol is Benzeneacetamide, 4-[2′-hydroxy-3′-[(1-methylethyl) amino] propoxy]-.
Atenolol (free base) is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37°C. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C).
Chlorthalidone is 2-Chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl) benzene sulfonamide:
- Chlorthalidone has a water solubility of 12 mg/100 mL at 20°C.
- Each TENORETIC 100 Tablet contains:
- Atenolol (TENORMIN®)…………………………………100 mg
- Chlorthalidone……………………………………………….. 25 mg
- Each TENORETIC 50 Tablet contains:
- Atenolol (TENORMIN®)…………………………………..50 mg
- Chlorthalidone………………………………………………….25 mg
Inactive ingredients: magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate.
Before taking Tenoretic, tell your doctor:
- If you have a sulfa allergy.
- If you are allergic to Tenoretic; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have any of these health problems: Heart block, shock caused by heart problems, or slow heartbeat.
- If you have heart failure (weak heart).
- If you have any of these health problems: Asthma or other breathing problems like COPD (chronic obstructive pulmonary disease).
- If you have an adrenal gland tumor called pheochromocytoma.
- If you are not able to pass urine.
This is not a list of all drugs or health problems that interact with this medicine.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Tenoretic with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Tenoretic?
- Tell all of your health care providers that you take Tenoretic. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how Tenoretic affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- Check blood pressure and heart rate as the doctor has told you.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may hide the signs of low blood sugar. Talk with the doctor.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- This medicine may make it harder to tell if you have signs of an overactive thyroid like fast heartbeat. If you have an overactive thyroid and stop taking Tenoretic all of a sudden, it may get worse and could be life-threatening. Talk with your doctor.
- Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
- Tell your doctor if you have too much sweat, fluid loss, throwing up, or loose stools. This may lead to low blood pressure.
- If you are on a low-salt or salt-free diet, talk with your doctor.
- Watch for gout attacks.
- If you have lupus, Tenoretic can make your lupus active or get worse. Tell your doctor right away if you get any new or worse signs.
- Do not stop taking Tenoretic all of a sudden. If you do, chest pain that is worse and in some cases heart attack may occur. The risk may be greater if you have certain types of heart disease. To avoid side effects, you will want to slowly stop Tenoretic as ordered by your doctor. Call your doctor right away if you have new or worse chest pain or if other heart problems occur.
- This medicine is a strong fluid-lowering drug (diuretic). Sometimes too much water and electrolytes (like potassium) in the blood may be lost. This can lead to severe health problems. Your doctor will follow you closely to change the dose to match your body’s needs.
- You may need extra potassium. Talk with your doctor.
- If you have had a very bad allergic reaction, talk with your doctor. You may have a chance of an even worse reaction if you come into contact with what caused your allergy. If you use epinephrine to treat very bad allergic reactions, talk with your doctor. Epinephrine may not work as well while you are taking Tenoretic.
- This medicine may make you sunburn more easily. Use care if you will be in the sun. Tell your doctor if you sunburn easily while taking Tenoretic.
- If you are 65 or older, use Tenoretic with care. You could have more side effects.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking Tenoretic, call your doctor right away.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is Tenoretic best taken?
Use Tenoretic as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Keep taking Tenoretic as you have been told by your doctor or other health care provider, even if you feel well.
- This medicine may cause you to pass urine more often. To keep from having sleep problems, try not to take too close to bedtime.
- Talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are the side effects of Tenoretic that I need to call my doctor about immediately?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
- Feeling cold.
- Very bad dizziness or passing out.
- Slow heartbeat.
- Shortness of breath, a big weight gain, or swelling in the arms or legs.
- Low mood (depression).
- Fever, chills, or sore throat; any unexplained bruising or bleeding; or feeling very tired or weak.
- Yellow skin or eyes.
- A burning, numbness, or tingling feeling that is not normal.
What are some other side effects of Tenoretic?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling dizzy, tired, or weak.
- Upset stomach or throwing up.
- Not hungry.
- Stomach cramps.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If overdose is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Tenoretic?
- Store at room temperature.
- Protect from light.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
PACKAGE/LABEL PRINCIPAL DISPLAY PANEL – 50 MG
- NDC 52427-382-90
- Rx Only
- Tenoretic® 50
(atenolol and chlorthalidone)
- Each tablet contains:
50 mg atenolol and
25 mg chlorthalidone
- 90 tablets
PACKAGE/LABEL PRINCIPAL DISPLAY PANEL – 100 MG
- NDC 52427-383-90
- Rx Only
- Tenoretic® 100
(atenolol and chlorthalidone)
- Each tablet contains:
100 mg atenolol and
25 mg chlorthalidone
- 90 tablets
SRC: NLM .