Sandostatin Dosage

Generic name: octreotide injection
Brand names: Sandostatin, Sandostatin LAR Depot
Drug class: Somatostatin and somatostatin analogs

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  INJ: 50 mcg per mL, 100 mcg per mL, 500 mcg per mL

Acromegaly

[50-100 mcg SC/IV tid]
Start: 50 mcg SC/IV tid; Max: 500 mcg/dose; 1500 mcg/day; Info: titrate to serum GH <5 ng/mL w/in 8h after dose or serum IGF-1 <1.9 units/mL (males) or <2.2 units/mL (females) after 2wk from start or dose change; doses >300 mcg/day rarely more effective; monitor GH or IGF-1 at least q6mo; D/C x4wk qy in pts w/ pituitary irradiation to assess disease activity, need for tx

Carcinoid tumor symptoms

[100-600 mcg/day SC/IV divided bid-qid]
Max: 500 mcg/dose; 1500 mcg/day; Info: for pts w/ severe diarrhea or flushing; titrate based on sx response

VIPoma symptoms

[150-750 mcg/day SC/IV divided bid-qid]
Start: 200-300 mcg/day SC/IV divided bid-qid x2wk; Max: 500 mcg/dose; Info: for pts w/ severe diarrhea; titrate based on sx response

Carcinoid crisis, acute

[50-500 mcg IV prn]
Max: 500 mcg/dose; 1500 mcg/day; Alt: 50 mcg/h IV infusion x8-24h

Carcinoid crisis prophylaxis

[250-500 mcg IV x1]
Info: give 1-2h preop

Diarrhea, secretory

[50-1500 mcg/day SC/IV divided qd-tid]
Start: 50 mcg SC/IV bid-tid, then may incr. by 100 mcg/dose q48h; Max: 500 mcg/dose up to 1500 mcg/day; Info: titrate based on response

Esophageal varices

[50 mcg/h IV x5 days]
Start: 50 mcg IV x1; Info: for acute variceal bleeding

Renal dosing

renal impairment: not defined, caution advised
HD: consider decr. usual dose, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined

Hepatic dosing

[not defined]
hepatic impairment: caution advised

 

SRC: NLM .