Sandostatin Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ: 50 mcg per mL, 100 mcg per mL, 500 mcg per mL
Acromegaly
- [50-100 mcg SC/IV tid]
- Start: 50 mcg SC/IV tid; Max: 500 mcg/dose; 1500 mcg/day; Info: titrate to serum GH <5 ng/mL w/in 8h after dose or serum IGF-1 <1.9 units/mL (males) or <2.2 units/mL (females) after 2wk from start or dose change; doses >300 mcg/day rarely more effective; monitor GH or IGF-1 at least q6mo; D/C x4wk qy in pts w/ pituitary irradiation to assess disease activity, need for tx
Carcinoid tumor symptoms
- [100-600 mcg/day SC/IV divided bid-qid]
- Max: 500 mcg/dose; 1500 mcg/day; Info: for pts w/ severe diarrhea or flushing; titrate based on sx response
VIPoma symptoms
- [150-750 mcg/day SC/IV divided bid-qid]
- Start: 200-300 mcg/day SC/IV divided bid-qid x2wk; Max: 500 mcg/dose; Info: for pts w/ severe diarrhea; titrate based on sx response
Carcinoid crisis, acute
- [50-500 mcg IV prn]
- Max: 500 mcg/dose; 1500 mcg/day; Alt: 50 mcg/h IV infusion x8-24h
Carcinoid crisis prophylaxis
- [250-500 mcg IV x1]
- Info: give 1-2h preop
Diarrhea, secretory
- [50-1500 mcg/day SC/IV divided qd-tid]
- Start: 50 mcg SC/IV bid-tid, then may incr. by 100 mcg/dose q48h; Max: 500 mcg/dose up to 1500 mcg/day; Info: titrate based on response
Esophageal varices
- [50 mcg/h IV x5 days]
- Start: 50 mcg IV x1; Info: for acute variceal bleeding
Renal dosing
- renal impairment: not defined, caution advised
- HD: consider decr. usual dose, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined
Hepatic dosing
- [not defined]
- hepatic impairment: caution advised
SRC: NLM .