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Generic name: octreotide injection
Brand names: Sandostatin, Sandostatin LAR Depot
Drug class: Somatostatin and somatostatin analogs

Medically reviewed by  A Ras MD.

What is Sandostatin used for?

Sandostatin is a prescription medicine used to treat diarrhea and flushing caused by cancer. It is used to treat acromegaly. Sandostatin may be given to you for other reasons.


Octreotide is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is known chemically as L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxy-methyl) propyl]-, cyclic (2→7)-disulfide; [R-(R*,R*)].

The molecular weight of octreotide is 1019.3 g/mol (free peptide, C49H66N10O10S2) and its amino acid sequence is:

octreotide amino acid sequence

SANDOSTATIN LAR DEPOT is available in a vial containing the sterile drug product, which when mixed with diluent, becomes a suspension that is given as a monthly intragluteal injection. The octreotide is uniformly distributed within the microspheres which are made of a biodegradable glucose star polymer, D,L-lactic and glycolic acids copolymer. Sterile mannitol is added to the microspheres to improve suspendability.

SANDOSTATIN LAR DEPOT is available as: sterile 6-mL vials in 3 strengths delivering 10 mg, 20 mg, or 30 mg octreotide-free peptide. Each vial of SANDOSTATIN LAR DEPOT delivers:

*Equivalent to 10 mg/20 mg/30 mg octreotide base.
Name of Ingredient 10 mg 20 mg 30 mg
octreotide acetate 11.2 mg* 22.4 mg* 33.6 mg*
D,L-lactic and glycolic acids copolymer 188.8 mg 377.6 mg 566.4 mg
mannitol 41.0 mg 81.9 mg 122.9 mg
Each syringe of diluent contains:
      carboxymethylcellulose sodium 14.0 mg
      mannitol 12.0 mg
      poloxamer 188 4.0 mg
      water for injection 2.0 mL


 Mechanism of Action

Octreotide exerts pharmacologic actions similar to the natural hormone, somatostatin. It is an even more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Like somatostatin, it also suppresses LH response to GnRH, decreases splanchnic blood flow, and inhibits release of serotonin, gastrin, vasoactive intestinal peptide, secretin, motilin, and pancreatic polypeptide.

By virtue of these pharmacological actions, octreotide has been used to treat the symptoms associated with metastatic carcinoid tumors (flushing and diarrhea), and VIP secreting adenomas (watery diarrhea).

Before taking Sandostatin, tell your doctor:

  • If you are allergic to Sandostatin; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Sandostatin with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Sandostatin?

  • Tell all of your health care providers that you take Sandostatin. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • High or low blood sugar may happen in some patients after Sandostatin is given. Talk with the doctor.
  • Check your blood sugar as you have been told by your doctor.
  • Gallbladder problems have happened. Sometimes, people had to be treated in the hospital. In some cases the gallbladder had to be removed. Discuss any questions with the doctor.
  • In women who have fertility problems from acromegaly, Sandostatin may improve fertility. This could lead to pregnancy. If you want to avoid pregnancy, use birth control while taking Sandostatin.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is Sandostatin best taken?

Use Sandostatin as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into the fatty part of the skin.
  • It may be given as a shot into a vein.
  • If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
  • Wash your hands before and after use.
  • Before giving the shot, let it come to room temperature. Do not heat Sandostatin.
  • Move the site where you give the shot with each shot.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • Do not use if solution changes color.
  • Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are the side effects of Sandostatin that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low thyroid levels like constipation; not able to handle cold; memory problems; mood changes; or a burning, numbness, or tingling feeling that is not normal.
  • Signs of gallbladder problems like pain in the upper right belly area, right shoulder area, or between the shoulder blades; yellow skin or eyes; fever with chills; bloating; or very upset stomach or throwing up.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Slow heartbeat.
  • A heartbeat that does not feel normal.
  • Swelling of belly.
  • Feeling very tired or weak.
  • Tell your doctor if you have signs of high or low blood sugar like breath that smells like fruit, dizziness, fast breathing, fast heartbeat, feeling confused, feeling sleepy, feeling weak, flushing, headache, more thirsty or hungry, passing urine more often, shaking, or sweating.

What are some other side effects of Sandostatin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Gas.
  • Flu-like signs.
  • Headache.
  • Constipation.
  • Stomach pain or diarrhea.
  • Dizziness.
  • Feeling tired or weak.
  • Pain where the shot was given.
  • Upset stomach or throwing up.
  • Hair loss.
  • Muscle or joint pain.
  • Back pain.
  • Nose or throat irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If overdose is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Sandostatin?

All products:

  • Store in a refrigerator. Do not freeze.
  • Store in the original container to protect from light.
  • You may store unopened containers at room temperature. If you store at room temperature, throw away any part not used after 2 weeks.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Single-dose container:

  • Throw away any part left over after the dose is given.

Multi-dose container:

  • Throw away any part not used 2 weeks after first use.




  • NDC 0078-0818-81
  • Sandostatin® LAR Depot
  • (octreotide acetate) for injectable suspension,
    for gluteal intramuscular use
  • 20 mg
  • For Intragluteal Injection
  • Rx only

PRINCIPAL DISPLAY PANEL NDC 0078-0818-81 Sandostatin® LAR Depot (octreotide acetate) for injectable suspension, for gluteal intramuscular use 20 mg For Intragluteal Injection Rx only NOVARTIS


  • NDC 0078-0825-81
  • Sandostatin® LAR Depot
  • (octreotide acetate) for injectable suspension,
    for gluteal intramuscular use
  • 30 mg
  • For Intragluteal Injection
  • Rx only

PRINCIPAL DISPLAY PANEL NDC 0078-0825-81 Sandostatin® LAR Depot (octreotide acetate) for injectable suspension, for gluteal intramuscular use 30 mg For Intragluteal Injection Rx only NOVARTIS


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