Generic name: Mometasone, olopatadine and mometa

Dosage Form: Nasal spray

Medically reviewed by A Ras MD. The last update was on  March 29, 2022.

What is Ryaltris?

Ryaltris is a prescribed nasal spray that has 2 drugs, olopatadine Hydrochloride, an antihistamine, as well as mometasone, a corticosteroid. Ryaltris is used for treating signs of allergies that are seasonal among people aged 12 and older.

It is unclear whether this medication has been proven safe or effective for children younger than 12 years old. age.

Important: Use only for use in the nose area only. Avoid spraying in your mouth or eyes.


Ryaltris is a metered-dose manual nasal spray unit containing an aqueous suspension of a fixed-dose combination of a histamine-1 (H1) receptor inhibitor (olopatadine hydrochloride) and a corticosteroid (mometasone furoate monohydrate).

Olopatadine hydrochloride is a white, sparingly water-soluble crystalline powder. The chemical name for olopatadine hydrochloride is 2-[(11Z)-11-[3-(dimethylamino)propylidene]-6Hbenzo[c][1]benzoxepin-2-yl]acetic acid hydrochloride. It has a molecular weight of 373.88, and its molecular formula is C21H23NO3•HCl with the following chemical structure:



Mometasone furoate monohydrate is an anti-inflammatory corticosteroid having the chemical name [(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2carboxylate;hydrate and the following chemical structure:

Ryaltris (Olopatadine Hydrochloride and Mometasone Furoate Monohydrate Nasal Spray): Uses, Dosage, Side Effects, Interactions, Warning

Mometasone furoate monohydrate is a white powder, with an empirical formula of C27H30Cl2O6•H2O and a molecular weight of 539.45. It is practically insoluble in water; slightly soluble in methanol, ethanol, and isopropanol; soluble in acetone and chloroform; and freely soluble in tetrahydrofuran. Its partition coefficient between octanol and water is >5000.

Ryaltris is a nasal spray containing an isotonic aqueous suspension of olopatadine hydrochloride (equivalent to 0.6% w/v olopatadine base) and mometasone furoate monohydrate (equivalent to 0.025% w/w mometasone furoate on the anhydrous basis). After initial priming (6 sprays), each metered spray delivers 100 microliters of suspension containing 665 mcg of olopatadine hydrochloride (equivalent to 600 mcg olopatadine base) and 25 mcg of mometasone furoate. Ryaltris also contains benzalkonium chloride, carboxymethyl cellulose sodium, dibasic sodium phosphate heptahydrate, edetate disodium, hydrochloric acid, microcrystalline cellulose, polysorbate 80, sodium chloride, sodium hydroxide, and water for injection. It has a pH of approximately 3.7

Mechanism of Action

Ryaltris contains both olopatadine hydrochloride and mometasone furoate. The mechanisms of action described below for the individual components apply to Ryaltris.

Who shouldn’t use Ryaltris?

Don’t use Ryaltris when you are sensitive to olopatadine hydrochloride or mometasone furoate monohydrate, or any of the other ingredients. Look at the end at the bottom of this article for a full listing of the ingredients. Talk to your healthcare professional for clarification if you’re not sure.

Before using Ryaltris

Before using Ryaltris be sure to inform your physician about all your medical conditions, such as those that:

What other medications can impact Ryaltris?

Inform your doctor about every medication you use such as prescription and over-the-counter supplements such as vitamins, herbal supplements.

Be sure to inform your doctor when you take any of the following medications:

Ryaltris and various other medications may interact with each other, leading to adverse negative effects.

Take note of the medicines you take. Make a list of all your medications and present it to your healthcare professional or pharmacist if you are given a new medication.

What should I do with Ryaltris?

Dosing Information

Indication and usage

Ryaltris is indicated for the treatment of symptoms of seasonal allergic rhinitis in adult and pediatric patients 12 years of age and older.

Dosage and administration

For nasal use only.

Dosage and strength

Nasal spray: 665 mcg of olopatadine hydrochloride and 25 mcg of mometasone furoate in each spray 4


Ryaltris is contraindicated in patients with known hypersensitivity to any ingredients of this medication. Hypersensitivity reactions, including wheezing, has occurred after nasal administration of mometasone furoate

What are the most important things to avoid when using Ryaltris?

Side effects of Ryaltris

Ryaltris could produce serious side effects for example:

The most commonly reported adverse effects are the following:

Contact your doctor whether you experience any symptoms that bother you or don’t disappear. This isn’t all of the possible adverse effects. For more details, consult your physician or pharmacist. Contact your physician to get medical advice on the effects of side effects. You can report any side effects to the FDA at 1-800-FDA-1088.

General information regarding the safe and efficient use of Ryaltris

Sometimes, medicines are prescribed for different reasons than those stated within the Patient Information. Don’t use this medication for any health condition that was not recommended. Don’t give it to others regardless of whether they are suffering from similar symptoms as you do. It could harm them.
It is possible to consult your physician and pharmacist to provide information specifically written for health professionals.

What are the ingredients of Ryaltris?

The active ingredients are Mometasone Furoate Monohydrate and olopatadine
Ingredients inactive: benzalkonium chloride, carboxymethyl cellulose sodium dibasic sodium-phosphate heptahydrate, hydrochloric acid, edetate disodium microcrystalline cellulose, and the polysorbate 80, sodium chloride sodium hydroxide, and water to inject.

Instructions for Use

Important: Use to spray your nostrils only. Don’t spray Ryaltris in your mouth or eyes.
Review the instructions for use prior to using Ryaltris and every time you receive a refill. There could be information that is new. This instruction does not substitute for speaking with your doctor regarding your medical condition or treatment. Before using Ryaltris ensure that your healthcare professional demonstrates to you how to utilize it. The bottle should be shaken thoroughly before every use.

Making your nasal spray bottle
The nasal spray needs to be primed prior to use the first time, and also if you haven’t used it for 14 days or longer. Prior to priming the spray bottle, shake it well.


Step 1. Remove the dust cap.
Step 2. Hold the nasal spray bottle with firmness and straight up using your middle and index finger to opposite sides of the applicator (on the finger rests) while holding the bottom of the bottle using your thumb.

Remove the dust cap from the spray pump tip of the bottle - Illustration

Step 3. Before first use, you push the pump rapidly and steadily six times before releasing the spray in the air. Keep it away from face and eyes till a thin mist forms.
The Ryaltris is now available for use.


Before first use, push down on the pump quickly and firmly 6 times, releasing the spray into the air, away from the eyes and face until a fine mist appears - Illustration

Utilizing your Ryaltris

Step 4. Gently blow your nose to clear your nostrils.

Gently blow your nose to clear your nostrils - Illustration
Step 5. Shake the bottle with a good shake prior to usage (morning as well as in the evening).
step 6. Hold the bottle securely using your middle and index finger to both sides of the applicator (on the finger rests) while holding the bottom of the bottle with your thumb.

 Hold the bottle firmly with your index and middle finger on either side of the applicator - Illustration
step 7. Hold 1 nostril closed using fingers. Place the tip of the sprayer into the opposite nostril, and then point it toward the exterior of the nose, but away from the nasal septum (the wall between the two nostrils).

Hold 1 nostril closed with a finger - Illustration
Step 8. Tilt your head towards the forward. Make sure the bottle is upright and then press it down quickly and with a firm grip on the finger rests in order to start the pump. Inhale (inhale) slowly through your nose while you spray. After that, breathe out your mouth. Make sure not to spray aerosol into your eyes or directly onto the nasal septum (the membrane that separates the 2 nostrils).

Tilt your head forward slightly. Keep the bottle upright and press down one time quickly and firmly on the finger rests to activate the pump - Illustration
Step 9. Repeat Steps 6 through 8 and applies another spray to that same nose.
Step 10. Repeat Steps 6 through 8 by spraying 2 times in the opposite nostril. Don’t breathe your nostrils for a minimum of 15 minutes after taking Ryaltris to ensure that you get all the medication. Don’t tilt your head towards the back. This will prevent the medication from entering your throat.
Step 11. Wipe the spray pump’s tip clean with a dry cloth or tissue.

Wipe the spray pump tip with a clean dry tissue or cloth - Illustration
step 12. Hold the spray pump unit, then put it back onto the tip of the sprayer of your bottle till you can hear the click.
Every bottle of Ryaltris has enough medicine to allow you to spray it 240 times following the initial (initial) spraying. Keep an eye on the quantity of sprays that you have used within each bottle. You should not count the sprays used to start priming on the bottle.

 Hold the spray pump unit and push the dust cap back on the spray pump tip of the bottle until you hear a click - Illustration

How do you clean your Ryaltris the sprayer pump in case it is blocked

Don’t try to remove the spray pump by inserting pins or another sharp object. This could harm the spray pump unit and you might not receive the proper dosage of medication.
Step 13. If the spray pump unit is blocked, you can remove it by gently pulling it upwards. The dust cap should be removed and then place the pump unit into warm water to soak.

If the spray pump unit becomes blocked, remove it by gently pulling upward - Illustration
step 14. After soaking for 15 minutes, clean the spray pump unit as well as the dust cap in warm water and let them dry completely.

After soaking for 15 minutes, rinse the spray pump unit and dust cap with warm water, and allow them to dry completely - Illustration
step 15. Place the dust cap on the tip of the sprayer and place the pump back onto the bottle.

 Place the dust cap on the spray pump tip and put the spray pump unit back on the bottle - Illustration
step 16. After following the steps to unblock your spray pump, refer to the priming of your Ryaltris pump prior to using the section above. Re-prime by using two sprays. Replace
the dust cap and the dust cap, and your Ryaltris is ready to use. Repeat the steps of unblocking when required.

How should I store Ryaltris?

Additional details

Always consult your doctor to confirm that the information provided on this page is applicable to your specific situation.

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