Pradaxa Dosage
Generic name: dabigatran
Drug class: Thrombin inhibitors
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: CAP: 75 mg, 110 mg, 150 mg
Thromboembolism/stroke prophylaxis
- [150 mg PO bid]
- Info: for non-valvular atrial fibrillation w/o mod-severe mitral stenosis or mechanical heart valve; to convert from warfarin, D/C warfarin, then start dabigatran when INR <2; to convert from other oral anticoagulants, D/C oral anticoagulant, then start dabigatran at next scheduled dose; to convert from parenteral anticoagulants, D/C parenteral anticoagulant, then start dabigatran 0-2h before next scheduled dose; consider holding tx 1-2 days before surgery or invasive procedure if CrCl >50 or 3-5 days if CrCl <50; do not open/dissolve cap
DVT/PE tx
- [150 mg PO bid]
- Start: ASAP after unfractionated heparin infusion D/C, or if transitioning from LMWH, give 0-2h before next LMWH dose would have been administered; Info: for use in pts initially treated w/ parenteral anticoagulant x5-10 days; consider holding tx 1-2 days before surgery or invasive procedure if CrCl >50 or 3-5 days if CrCl <50; do not open/dissolve cap
DVT/PE prophylaxis, recurrent
- [150 mg PO bid]
- Info: to convert from warfarin, D/C warfarin, then start dabigatran when INR <2; to convert from other oral anticoagulants, D/C oral anticoagulant, then start dabigatran at next scheduled dose; to convert from parenteral anticoagulants, D/C parenteral anticoagulant, then start dabigatran 0-2h before next scheduled dose; consider holding tx 1-2 days before surgery or invasive procedure if CrCl >50 or 3-5 days if CrCl <50; do not open/dissolve cap
DVT/PE prophylaxis, hip replacement
- [220 mg PO qd x28-35 days]
- Start: 110 mg PO x1 dose 1-4h postop or 220 mg PO qd on day after surgery; Info: consider holding tx 1-2 days before surgery or invasive procedure if CrCl >50 or 3-5 days if CrCl <50; do not open/dissolve cap
VTE prophylaxis, cardioversion
- [150 mg PO bid]
- Start: at least 3wk before cardioversion; Info: for pts w/ afib/flutter duration >48h or unknown; continue tx x4wk after procedure
Renal dosing
- [thromboembolism/stroke prophylaxis]
- CrCl 15-30: 75 mg bid; CrCl <15: avoid use
- HD/PD: avoid use
- [*VTE prophylaxis, cardioversion]
- renal impairment: not defined
- HD/PD: not defined
- [all other indications]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
SRC: NLM .