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Generic name: pantoprazole
The brand name is Protonix
The class of drugs: Proton pump inhibitors



what is pantoprazole


Pantoprazole is an inhibitor of the proton pump which reduces the amount of acid produced in the stomach.

Pantoprazole can be used to treat Erosive reflux (damage of the stomach due to stomach acid that is caused by gastroesophageal reflux disease, also known as GERD) for adults and young children who are at or above five years old. Pantoprazole can be prescribed for up to eight weeks, at a time, until your esophagus is healed.

Pantoprazole can also be used to treat Zollinger-Ellison Syndrome and other disorders that cause excessive stomach acid.


Pantoprazole is not a remedy for immediate relief of heartburn symptoms.

Heartburn can be confused with the initial signs of a heart attack. Take immediate medical attention when you experience chest pain or feeling of heaviness that is spreading to your shoulder or arm nausea, sweating, and general discomfort.

Pantoprazole treatment for long periods of time may also make it more difficult for the body’s ability to take in vitamin B12, which could result in a lack in this vitamin. Discuss with your doctor in the event that you require long-term treatment or if you are concerned about vitamin B-12 deficiencies.

Pantoprazole may cause kidney issues. Tell your doctor when you’re urinating less than normal or if there is an increase in blood levels in the urine.

Diarrhea could be an indication of a new infection. Contact your doctor when you experience diarrhea that is fluid or contains blood.

Pantoprazole could result in the development of new or more severe symptoms of Lupus. Consult your physician if you suffer from joint pain or an itchy rash on your arms or cheeks which gets worse when exposed to sunlight.

You could be more likely to sustain fractured bones while taking this medication long-term or more than one time every day.


Before you start taking this medicine, make sure to consult your doctor.

Heartburn is a common sign of heart attack. Find medical assistance immediately If you experience discomfort in your chest that extends to your shoulder or jaw and you experience anxiety or lightheadedness.

This medicine is in the following situations:

  • Also, you may take a medication that has the ingredient rilpivirine (Edurant Complera, Edurant, Juluca, Odefsey);
  • If you have breathing issues or kidney problems or a severe allergic reaction following taking pantoprazole previously or
  • you’re allergic to pantoprazole or other similar drugs (lansoprazole or omeprazole Nexium, Prevacid, Prilosec, and many others).

Speak to your doctor if were ever diagnosed with:

  • the magnesium levels are low in your blood.
  • lupus; or
  • osteoporosis, or lower bone mineral density.

It is possible to suffer a fractured bone if you are taking pantoprazole for a long time or more than one time daily. Discuss with your physician ways to ensure your bones are healthy particularly if you’re an older adult.

It isn’t known if this medication will cause harm to a baby who is not yet born. Inform your doctor if are expecting or planning to be pregnant.

Do not breastfeed during the course of this medication.

Pantoprazole is not a prescription drug for use by any person less than 5 years old.


How do I make use of pantoprazole?

Follow the exact dosage as directed by your physician. Follow the directions on the prescription label and also read the medication guide or instructions sheets. Make sure you use the medicine exactly as prescribed.

Utilize the lowest dosage to get the shortest time to treat your condition.

Pantoprazole is consumed by mouth (oral) or administered for infusion in the vein (injection). The healthcare professional may instruct you on the proper use of the injection yourself.

Pantoprazole tablets are consumed in the mouth, whether with or without food. The oral granules must be consumed 30 minutes prior to meals.

Don’t crush, chew or cut or break the tablet. Suck it up whole.

The oral granules are mixed with apple juice or applesauce and then administered by the mouth or through the Nasogastric (NG) tube.

Follow and read carefully any instructions that are included in your medication. Consult your physician or pharmacist for assistance if you have concerns.

Make sure to take this medicine for the prescribed length of time, even if symptoms do not improve immediately.

Consult your physician if your symptoms don’t improve, or worsen during the course of this medication.

Pantoprazole may produce false results in certain tests for medical purposes. Inform your doctor or lab personnel that you are taking this medication.

Pantoprazole could also influence the results of a urine test for drug screening and cause incorrect results. Inform the lab staff that you are taking this medication.

Keep this medicine in a cool, dry at a temperature that is free of heat, moisture, and light.


Dosing information

Usual Adult Dose for Erosive Esophagitis:

Treatment of Erosive Esophagitis:
40 mg taken orally every day for up to eight weeks; however, an additional eight weeks could be considered for patients who haven’t fully recovered after the first treatment. Safety and efficacy after 16 weeks of treatment are not yet established.

Maintenance of Healing of Erosive Esophagitis:
40 mg once orally, every day. The controlled studies have been limited to up to 12 months of treatment with pantoprazole.

Usual Adult Dose for Gastroesophageal Reflux Disease:

40 mg once every day for 7-10 days, given via intravenous infusions over a time that is 15 mins. The intravenous treatment should be stopped at the time the patient is in a position to resume oral treatment.

Ingestion: 40 mg every day for short-term use (up to 8 weeks) However, the possibility of an additional 8 weeks can be considered for patients that aren’t healing following the first treatment. The safety and effectiveness of this treatment after 16 weeks of treatment are not yet established.

Usual Adult Dose for Duodenal Ulcer:

Study (n=54)
40 mg taken orally every daily, the dosage was increased every 12 weeks in 40 mg increments, to the maximum of 120 mg daily, lasting 28 weeks. The results of the study have shown that monotherapy, with dosages daily of up to 40 mg were connected with total healing of the duodenal ulcer with up to 87 % and 94 percent of patients after 8 and 4 weeks, respectively.

Usual Adult Dose for Gastric Ulcer:

40 mg taken orally every day. Research has shown that monotherapy using regular doses at 40 mg has been linked to total healing of gastric ulcers with as high as 87 percent and 97% patients after 4 and 8 weeks, respectively.

Usual Adult Dose for Helicobacter pylori Infection:

Study (n=242)”Triple therapy:
40 mg taken orally twice daily for 7 days. Usually when used in conjunction with clarithromycin or metronidazole or amoxicillin to eliminate Helicobacter Pylori. This is followed by 40 mg of pantoprazole taken orally daily up to day 28. Triple therapy has led to an eradication rate of more than 95 percent.

The QUADRATE Study (n=405) — Quadruple therapy:
40 mg taken orally twice daily for 7 days. This is followed by concomitant treatment with bismuth subcitrate and Tetracycline every four times a day and metronidazole 200mg 3 times per day, and 400 mg before bedtime. Helicobacter Pylori elimination was achieved with 82 percent of patients.

Usual Adult Dose for Zollinger-Ellison Syndrome:

Parenteral 80 mg each 12 hours delivered via a 15-minute infusion. Daily doses that exceed 240 mg, administered in equally divided doses using a 15 minutes of infusion or for longer than 6 days haven’t been examined.

Oral 40 mg twice daily up to max 242 mg daily. Some patients have been treated with pantoprazole for over two years.

Usual Adult Dose for Stress Ulcer Prophylaxis:

Study (n=21) — Stress Prophylaxis against bleeding from Ulcers for the Critical Care Setting:
80 mg two times a day as a bolus infusion spread over 15 minutes, up to a maximum daily dose of 240 mg broken into 3 equal dosages.

Study (n=20 ) Study (n=20) Peptic Ulcer prophylaxis for rebleeding after hemostasis within the Critical Care Setting:
A bolus of 80 mg was administered intravenously then a continuous infusion of 8 mg/hr over 3 days. After that, the treatment may be continued using an orally administered PPI.

Usual Adult Dose for Peptic Ulcer:

Study (n=21) Study (n=21) Stress Prophylaxis for bleeding from ulcers within the Critical Care Setting:
80 mg two times a day as a bolus infusion spread over 15 minutes, up to a maximum daily dose of 240 mg broken into 3 equal dosages.

Study (n=20 ) Study (n=20) Peptic Ulcer prophylaxis to prevent rebleeding following bleeding in the Critical Care Setting:
A bolus of 80 mg was administered intravenously then a continuous infusion of 8 mg/hr for three days. Following this, the treatment may be continued using an orally administered PPI.

How do I deal with it if do not take the dose?

Take the medication as quickly as you are able, but take a break from your missed dosage if you are nearing the time to take the next dose. Don’t take two doses at once.

How do I react if consume too much?

For medical emergencies, seek emergency medical attention or contact toll-free the Poison Help line at 1-800-222-1222.

What should I be aware of when making use of pantoprazole?

This medication can induce diarrhea. This could be a sign of a new infection. If you experience diarrhea that is bloody or watery and bloody, consult your physician. Do not use the medicine to treat diarrhea unless you are advised by your physician to.

Pantoprazole side effects

Take immediate medical attention If you exhibit symptoms that you are experiencing an allergic reaction due to the drug pantoprazole such as asthma; hives and swelling of your lips, face, and throat.

Contact your doctor immediately If you suffer from:

  • extreme stomach pain, diarrhea that’s either bloody or watery;
  • unintentional pain or discomfort in your wrist, hip, or back
  • swelling or bruising when intravenous pantoprazole injections were administered;
  • kidney issues such as rash, fever nausea, lack of appetite, joint pains, and urination less frequently than normal and having the presence of blood or urine in your system, weight loss
  • Low magnesium dizziness, rapid or irregular heartbeat and shaking (shaking) or muscles that jerk that make you feel jittery, muscular muscles spasms or cramps or pains in your feet and hands coughing or feeling of choking or
  • New or worsening signs of lupus joint pain and a rash that appears on your arms or cheeks that gets worse in the sun.

Long-term use of pantoprazole can result in stomach-related growths known as fundus polyps. Discuss with your physician about the risk.

If you take pantoprazole for more than 3 years, you could be developing an insufficiency of vitamin B-12. Discuss with your doctor how to deal with this issue in the event that you are diagnosed with it.

Common side effects of pantoprazole are:

  • headache, dizziness;
  • stomach pain, gas, nausea, vomiting, diarrhea;
  • joint pain; or
  • symptoms of fever, rash, or cold-like symptoms (most frequent in children).).

This is not a comprehensive list of all side effects. other side effects could occur. Consult your physician for advice regarding medical the effects. You can report symptoms to FDA at 1-800-FDA-1088.


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