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Generic name: patisiran 
The brand name is Onpattro
Drug class: Miscellaneous metabolic agents


What is Onpattro?


Onpattro (patisiran) A double-stranded small interfering, ribonucleic acid (siRNA) designed as a lipid-based complex injection.

Onpattro is a prescription medicine used to treat polyneuropathy (damage of multiple nerves throughout the body) in adults with hereditary transthyretin-mediated amyloidosis (hATTR).

Onpattro is administered by infusions intravenously (IV) Infusion.



Follow all the instructions on the medicine label and the package. Be sure to inform your healthcare professionals about your medical ailments, allergies, as well as the medicines you are taking.


Before you start taking this medicine, make sure to consult your doctor

Before taking Onpattro, tell your doctor about any medical issues or allergies.

It is unclear if Onpattro could cause harm to a baby who is not yet born. Consult your physician if you are expecting or planning to be pregnant.

If you’re expecting then your name might be added to an ob-gyn registry to monitor how patisiran affects the baby. the infant.

It might not be safe to breastfeed while taking this medication. Consult your physician about any potential risks.

How Onpattro is administred 

Onpattro is administered as an injection into the vein. The healthcare professional will administer the injection every three weeks.

The medicine should be administered slowly and the infusion could take up to an hour to finish.

Contact your physician If you experience any pain, burning or itching around your needle of the IV when Onpattro is injecting.

There are additional medications to help you avoid dangerous side effects as well as an adverse reaction to the infusion.

The doctor may recommend that you take additional vitamin A while taking Onpattro. You should only take your vitamin A dosage as your medical professional has advised, particularly in case you are expecting. Overdoses of vitamin A can result in vision problems and other serious side effects.

Consult your physician immediately If you experience vision problems (especially at the night) when you take vitamin A.

Doses for Onpattro are determined by weight. Your dose needs may change if you gain or lose weight.

There is a chance that you will require frequent medical tests. Even if there are no symptoms tests can aid your doctor in determining the effectiveness of this medication. You might also require regular eye examinations.


Dosing information

Usual Adult Dose for Amyloidogenic Transthyretin Amyloidosis:

Dosing is based upon the actual body weight. Premedication is recommended at minimum 60 minutes prior to the time of infusion

Less than 100 kg: 0.3 mg/kg via IV infusion every 3-4 weeks
A weight of 100kg or more 30 mg by IV infusions every 3 weeks

The initial rate of infusion should be 1 mL/min during the first 15 minutes. Then, it should increase to 3 mL/min throughout the duration of the infusion. In case of associated reaction, the duration of the infusion could be prolonged See the administration guidelines for specific instructions for infusion

PREMEDICATION: Take a dose on the day of infusion, at least 60 minutes prior to the start of the infusion
Acetaminophen 500 mg orally
IV corticosteroid (e.g. dexamethasone 10 mg or similar)
IV H1 blocker (e.g. diphenhydramine 50 mg, or equivalent)
IV H2 blocker (e.g. ranitidine 50 mg, or equivalent)

Prescriptions are necessary to decrease the chance of developing infusion-related adverse reactions (IRR).
If IV medications are not accessible or are not well tolerated oral equivalents can be considered.
If patients are tolerated by the infusion but are experiencing adverse reactions to the corticosteroid prescription cut down corticosteroid dose to 2.5 mg increments, to an IV dose that is at least dexamethasone 5 mg or the equivalent
Some patients might require greater or additional amounts of one or several prescription medications to lower the chance of IRRs.

Use: For the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis.


If I do not take a dose?

Consult your physician for further instructions If you do not make an appointment with your Onpattro.


How do I react if take too much?

Because Onpattro is administered by a health expert in a medical environment so an overdose is not likely to occur.


What are the most important things to avoid when using Onpattro?

Follow your doctor’s advice regarding any limitations on foods, drinks or any activity.


Onpattro side effects

Take immediate medical attention If you show symptoms that you are experiencing an allergic reaction Onpattro: hives; difficulty breathing or swelling of your lips, face and tongue.

There are some side effects that can happen in the course of the injection. Contact your physician when you feel hot dizzy, nauseated, faint, or experience headache, rapid heartbeats or swelling of your face and stomach and chest pain or difficulty breathing.

Common Onpattro side effects may include:

  • cold symptoms like congestion, sneezing and sore throat.

This isn’t an exhaustive list of possible side effects, and others could happen. Consult your physician to seek medical advice on adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.


What other medications can have an effect on Onpattro?

Other medications can interact with Onpattro. This includes prescription and over-the-counter medicines as well as vitamins and herbal products. Inform your doctor about all the medicines you are currently taking and any medication you begin or stop taking.

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