Mirabegron Dosage
Brand names: Myrbetriq, Myrbetriq Granules
Dosage forms: oral suspension, extended release (8 mg/mL); oral tablet, extended release (25 mg; 50 mg)
Drug class: Urinary antispasmodicsMedically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: ER TAB: 25 mg, 50 mg
Overactive bladder
- [monotherapy]
- Dose: 25-50 mg PO qd; Start: 25 mg PO qd, may incr. to 50 mg PO qd after 4-8wk; Max: 50 mg/day; Info: do not cut/crush/chew tab
- [combo tx]
- Dose: 25-50 mg PO qd; Start: 25 mg PO qd, may incr. to 50 mg PO qd after 4-8wk; Max: 50 mg/day; Info: give w/ solifenacin; do not cut/crush/chew tab
Renal dosing
- [see below]
- eGFR 15-29: max 25 mg/day; eGFR <15: avoid use
- HD/PD: avoid use
Hepatic dosing
- [adjust dose amount]
- Child-Pugh Class B: max 25 mg/day; Child-Pugh Class C: avoid use
Recommended Peds Dosing
- Dosage forms: ER TAB: 25 mg, 50 mg; ER SUSP: 8 mg per mL
Detrusor overactivity, neurogenic
- [ER suspension form, 3 yo and older, 11-21 kg]
- Dose: 24-48 mg PO qd; Start: 24 mg PO qd, may incr. to 48 mg PO qd; Max: 48 mg /day; Info: give w/ food
- [ER suspension form, 3 yo and older, 22-34 kg]
- Dose: 32-64 mg PO qd; Start 32 mg PO qd, may incr. to 64 mg PO qd; Max: 64 mg/day; Info: give w/ food
- [ER suspension form, 3 yo and older, >35 kg]
- Dose: 48-80 mg PO qd; Start: 48 mg PO qd, may incr. to 80 mg PO qd after 4-8wk; Max: 80 mg/day; Info: give w/ food
- [ER tablet form, 3 yo and older, >35 kg]
- Dose: 25-50 mg PO qd; Start: 25 mg PO qd, may incr. to 50 mg PO qd after 4-8wk; Max: 50 mg/day; Info: give w/ food; do not cut/crush/chew tab
Renal dosing
- [ER suspension form, 3 yo and older, 11-21 kg]
- eGFR 15-29: max 24 mg/day; eGFR <15: avoid use
- HD/PD: avoid use
- [ER suspension form, 3 yo and older, 22-34 kg]
- eGFR 15-29: max 32 mg/day; eGFR <15: avoid use
- HD/PD: avoid use
- [ER suspension form, 3 yo and older, >35 kg]
- eGFR 15-29: max 48 mg/day; eGFR <15: avoid use
- HD/PD: avoid use
- [ER tablet form, 3 yo and older, >35 kg]
- eGFR 15-29: max 25 mg/day; eGFR <15: avoid use
- HD/PD: avoid use
Hepatic dosing
- [ER suspension form, 3 yo and older, 11-21 kg]
- Child-Pugh Class B: max 24 mg/day; Child-Pugh Class C: avoid use
- [ER suspension form, 3 yo and older, 22-34 kg]
- Child-Pugh Class B: max 32 mg/day; Child-Pugh Class C: avoid use
- [ER suspension form, 3 yo and older, >35 kg]
- Child-Pugh Class B: max 48 mg/day; Child-Pugh Class C: avoid use
- [ER tablet form, 3 yo and older, >35 kg]
- Child-Pugh Class B: max 25 mg/day; Child-Pugh Class C: avoid use
SRC: NLM .