Kadian Dosage

Generic name: morphine (oral)
Brand names: KadianMS Contin
Drug class: Narcotic analgesics

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  ER CAP: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 80 mg, 100 mg, 200 mg

Pain, mod-severe chronic

[opioid-nontolerant pts]
Dose: individualize dose PO q12-24h; Start: 30 mg PO q24h, may incr. dose q1-2 days; Info: use alternative in opioid-naive pts; use lowest effective dose, shortest effective tx duration; consider low start dose, titrate slowly in pts 65 yo and older; may open cap, but do not crush/chew/dissolve contents; >60 mg/dose, >120 mg/day, 100 mg cap, 200 mg cap for use in opioid-tolerant pts only; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use
[opioid-tolerant pts]
Dose: individualize dose PO q12-24h; Start: individualize based on current opioid intake, see pkg insert for conversion; Info: use lowest effective dose, shortest effective tx duration; may incr. dose q1-2 days; consider low start dose, titrate slowly in pts 65 yo and older; may open cap, but do not crush/chew/dissolve contents; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use

Renal dosing

CrCl 10-50: decr. usual dose by 25%, titrate slowly; CrCl <10: avoid use
HD/PD: avoid use

Hepatic dosing

[adjust dose amount]
cirrhosis: decr. start dose, titrate slowly

 

SRC: NLM .