Jynarque Dosage

Generic name: tolvaptan
Brand names: Jynarque, Samsca

Medically reviewed by A Ras MD.

Recommended Adult Dosing

Dosage forms: TAB: 15 mg, 30 mg, 45 mg, 60 mg, 90 mg

Restricted Distribution in US

Autosomal dominant polycystic kidney dz

[60-120 mg/day PO divided bid]

Start: 45 mg PO qam and 15 mg PO qpm, may incr. to 60 mg PO qam and 30 mg PO qpm, then to 90 mg PO qam and 30 mg PO qpm; Info: for slowing kidney fxn decline; give 1st dose in am, 2nd dose 8h later; may incr. dose no more frequently than qwk; avoid fluid restriction during tx

Renal dosing

CrCl >60: no adjustment; CrCl 10-60: not defined, caution advised; CrCl <10: avoid use; anuria: contraindicated

HD/PD: not defined

Hepatic dosing

hepatic dz (except uncomplicated polycystic liver dz): contraindicated

SRC: NLM .

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