Integrilin Dosage

Generic name: eptifibatide
Drug class: Glycoprotein platelet inhibitors

Medically reviewed by  A Ras MD. Last updated on May 28, 2022.

Recommended Adult Dosing

Dosage forms:  INJ

Acute coronary syndrome

[2 mcg/kg/min IV]

Start: 180 mcg/kg/dose up to 22.6 mg IV x1; Max: 15 mg/h infusion; Info: give until discharge or CABG surgery up to 72h duration; if undergoing PCI, give until discharge or x18-24h post-procedure up to 96h duration; may use w/ aspirin, heparin

Percutaneous coronary intervention

[2 mcg/kg/min IV]

Start: 180 mcg/kg/dose IV up to 22.6 mg x1 before procedure; Max: 15 mg/h infusion; Info: repeat bolus dose x1 10min after initial dose; give infusion for at least 12h up to discharge or x18-24h post-procedure; may use w/ aspirin, heparin

Renal dosing

[acute coronary syndrome]

CrCl <50: 180 mcg/kg/dose IV up to 22.6 mg x1, then 1 mcg/kg/min, max 7.5 mg/h

HD/PD: contraindicated

[PCI]

CrCl <50: 180 mcg/kg/dose IV up to 22.6 mg x1, then 1 mcg/kg/min, max 7.5 mg/h; Info: repeat bolus dose x1 10min after initial dose

HD/PD: contraindicated

Hepatic dosing

[not defined]

SRC: NLM .