Hylenex Dosage

Generic name: hyaluronidase (injection)
Brand names: Amphadase, Hylenex, Vitrase
Drug class: Miscellaneous uncategorized agents

Medically reviewed by A Ras MD.

Recommended Adult Dosing

Dosage forms: INJ

Hypodermoclysis, adjunct tx

[150 units SC X1, given before clysis hydration of 1000 mL or more]

Alt: 150 units added to clysis hydration up to 200 mL, given via SC infusion x1; Info: rate and volume of clysis should not exceed those for IV infusion; consider 3 units (0.02 mL) intradermal skin test 30min before use

Absorption and dispersion of injected drugs, adjunct tx

[150 units added to injection solution, given SC x1]

Alt: 150 units SC x1, given before admin. of injected drug; Info: dose range 50-300 units; consider 3 units (0.02 mL) intradermal skin test 30min before use

SC urography, adjunct tx

[75 units SC x1 over each scapula, followed by contrast medium at same site]

Info: for pts unable to receive IV urographic contrast media; pts should be in prone position; consider 3 units (0.02 mL) intradermal skin test 30min before use

Extravasation tx, chemo-associated

[150-900 units SC x1 divided into clockwise injections around extravasation site]

Alt: 150-900 units IV x1 via existing IV line; Info: usual dose is 150 units (1 mL) for each 1 mL of extravasated docetaxel, paclitaxel, or vinca alkaloids

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing