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Encorafenib Dosage

Generic name: encorafenib
Brand name: Braftovi
Drug class: Multikinase inhibitors

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  CAP: 75 mg

Melanoma, unresectable or metastatic

[450 mg PO qd]
Info: for pts w/ BRAF V600E or V600K mutation; use w/ binimetinib; decr. dose to max 300 mg PO qd if binimetinib withheld

Colorectal CA, metastatic

[300 mg PO qd]
Info: for pts w/ BRAF V600E mutation; use w/ cetuximab

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined
HD/PD: not defined

Hepatic dosing

Child-Pugh Class A: no adjustment; Child-Pugh Class B or C: not defined

 

SRC: NLM .

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