Eliquis Dosage

Generic name: apixaban
Drug class: Factor Xa inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 2.5 mg, 5 mg

Thromboembolism/stroke prophylaxis

[5 mg PO bid]

Info: for non-valvular atrial fibrillation w/o mod-severe mitral stenosis or mechanical heart valve; decr. dose to 2.5 mg PO bid if at least 2 of the following: 80 yo or older, wt <60 kg, Cr >1.5; to convert from warfarin, D/C warfarin, then start apixaban when INR <2; to convert from other anticoagulants, D/C other anticoagulant, then start apixaban at next scheduled anticoagulant dose; hold tx >24h before surgery or invasive procedure w/ low bleeding risk or >48h if moderate-high bleeding risk

DVT prophylaxis

[hip replacement]

Dose: 2.5 mg PO bid x35 days; Start: 12-24h postop

[knee replacement]

Dose: 2.5 mg PO bid x12 days; Start: 12-24h postop

DVT/PE prophylaxis, recurrent

[2.5 mg PO bid]

Info: to convert from warfarin, D/C warfarin, then start apixaban when INR <2; to convert from other anticoagulants, D/C other anticoagulant, then start apixaban at next scheduled anticoagulant dose; hold tx >24h before surgery or invasive procedure w/ low bleeding risk or >48h if moderate-high bleeding risk

DVT/PE tx

[5 mg PO bid]

Start: 10 mg PO bid x7 days; Info: to convert from warfarin, D/C warfarin, then start apixaban when INR <2; to convert from other anticoagulants, D/C other anticoagulant, then start apixaban at next scheduled anticoagulant dose; hold tx >24h before surgery or invasive procedure w/ low bleeding risk or >48h if moderate-high bleeding risk

VTE prophylaxis, cardioversion

[5 mg PO bid]

Start: at least 3wk before cardioversion; Info: for pts w/ afib/flutter duration >48h or unknown; continue tx x4wk after procedure

Renal dosing

[thromboembolism/stroke prophylaxis]

Cr <1.5: 2.5 mg bid if also 80 yo or older and wt <60 kg; Cr >1.5: 2.5 mg bid if also 80 yo or older and/or wt <60 kg; CrCl <15: not defined

HD: 2.5 mg bid if also 80 yo or older and/or wt <60 kg; no supplement after dialysis; PD: not defined

[VTE prophylaxis, cardioversion]

renal impairment: not defined

HD/PD: not defined

[all other indications]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

Child-Pugh Class A: no adjustment; Child-Pugh Class B: not defined; Child-Pugh Class C: avoid use

SRC: NLM .