Dabrafenib Dosage

Dosage forms:  CAP: 50 mg, 75 mg

Melanoma

[adjuvant tx]

Dose: 150 mg PO q12h for up to 1y; Info: for pts w/ BRAF V600E or V600K mutation; use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

[unresectable or metastatic dz]

Dose: 150 mg PO q12h; Info: for use as monotherapy in pts w/ BRAF V600E mutation, or in combo w/ trametinib for pts w/ BRAF V600E or V600K mutation; give at least 1h before or 2h after meals; do not open cap

Non-small cell lung CA, metastatic

[150 mg PO q12h]

Info: for pts w/ BRAF V600E mutation; use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

Anaplastic thyroid CA, locally advanced or metastatic

[150 mg PO q12h]

Info: for pts w/ BRAF V600E mutation; use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

BRAF V600E-positive solid tumors, unresectable or metastatic

[150 mg PO q12h]

Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

Renal dosing

[see below]

eGFR >15: no adjustment; eGFR <15: not defined

HD/PD: not defined

Hepatic dosing

[see below]

bilirubin 1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN and any AST: not defined