Colcrys Dosage

Generic name: colchicine
Brand names: Colcrys, Mitigare
Drug class: Antigout agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 0.6 mg

Acute Gout therapy

[1.2 mg PO x1, then 0.6 mg PO 1h later x1]

Max: 1.8 mg total dose/course; Info: do not repeat x3 days

Gout prophylaxis

[0.6 mg PO qd-bid]

Max: 1.2 mg/day; Info: wait 12h after acute gout flare tx before resuming prophylaxis

Familial Mediterranean fever

[1.2-2.4 mg/day PO divided qd-bid]

Max: 2.4 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

Behcet Disease

[0.6 mg PO bid-tid]

Info: use lowest effective dose

Recurrent Pericarditis

[0.6 mg PO qd-bid]

Info: use lowest effective dose

Renal dosing

[gout, acute]

CrCl <30: consider decr. usual dose, do not redose x2wk; Info: consider alternate tx if pt requires repeated courses; avoid use if already receiving colchicine for gout prophylaxis

HD: max 0.6 mg total dose/course, do not redose x2wk; no supplement after dialysis; PD: not defined; Info: avoid use if also receiving colchicine for gout prophylaxis; avoid chronic use

[gout prophylaxis]

CrCl <30: start 0.3 mg qd, incr. dose only if close monitoring; Info: contraindicated in pts w/ both renal and hepatic impairment

HD: 0.3 mg 2x/wk; no supplement after dialysis; PD: not defined; Info: contraindicated in pts w/ both renal and hepatic impairment

[familial Mediterranean fever]

CrCl 30-80: consider decr. usual dose; CrCl <30: start 0.3 mg qd, incr. dose only if close monitoring

HD: start 0.3 mg qd, incr. dose only if close monitoring; no supplement after dialysis; PD: not defined

[off-label uses]

renal impairment: not defined, consider renal dosing for approved uses for guidance

HD/PD: not defined, consider renal dosing for approved uses for guidance

Hepatic dosing

[gout, acute]

severe impairment: no adjustment, do not redose x2wk, consider alternate tx if pt requires repeated courses; Info: avoid use in pts w/ hepatic impairment and receiving colchicine for gout prophylaxis

[gout prophylaxis]

severe impairment: consider decr. dose; Info: contraindicated in pts w/ both renal and hepatic impairment

[familial Mediterranean fever]

severe impairment: consider decr. dose

[off-label uses]

hepatic impairment: not defined, consider hepatic dosing for approved uses for guidance

 Recommended Peds Dosing

Dosage forms:  TAB: 0.6 mg

Gout prophylaxis

[>16 yo]

Dose: 0.6 mg PO qd-bid; Max: 1.2 mg/day

Familial Mediterranean fever

[4-6 yo]

Dose: 0.3-1.8 mg/day PO divided qd-bid; Max: 1.8 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

[6-12 yo]

Dose: 0.9-1.8 mg/day PO divided qd-bid; Max: 1.8 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

[>12 yo]

Dose: 1.2-2.4 mg/day PO divided qd-bid; Max: 2.4 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

Hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance

SRC: NLM .