Cinvanti Dosage

Generic name: Aprepitant Injection
Drug class: NK1 receptor antagonists

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: for PO aprepitant dosing see aprepitant or Emend; for IV fosaprepitant dosing see fosaprepitant or Emend Injection

Nausea/vomiting prevention, chemo-related

[highly-emetogenic chemo]

Dose: 130 mg IV x1 on day 1; Start: 30min before chemo; Info: give w/ corticosteroid and 5-HT3 antagonist

[moderately-emetogenic chemo, 1-day regimen]

Dose: 130 mg IV x1 on day 1; Start: 30min before chemo; Info: give w/ corticosteroid and 5-HT3 antagonist

[moderately-emetogenic chemo, 3-day regimen]

Dose: 100 mg IV x1 on day 1, then oral aprepitant 80 mg PO qd on days 2-3; Start: 30min before chemo; Info: give w/ corticosteroid and 5-HT3 antagonist

Renal dosing

renal impairment: no adjustment needed.

HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

SRC: NLM .