Zynlonta Dosage

Generic name: loncastuximab tesirine-lpyl
Drug class: Miscellaneous antineoplastics

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Large B-cell lymphoma, relapsed or refractory

[0.15 mg/kg/dose IV x1 on day 1 of 21-day cycle x2 cycles, then 0.075 mg/kg/dose IV x1 on day 1 of 21-day cycle starting cycle 3 until dz progression]

Info: use adjusted wt = [35 kg/m^2 x (height in meters)^2] to calculate dose if BMI 35 kg/m^2 or greater; for pts w/ diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low-grade lymphoma, or high-grade B-cell lymphoma who have received at least 2 lines of tx

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

Hepatic dosing

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN and any AST: not defined

SRC: NLM .